Clinical Hematology International

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Volume 2, Issue 1, March 2020, Pages 5 - 12

Current Status and Future Directions in Graft-Versus-Host Disease Prevention Following Allogeneic Blood and Marrow Transplantation in Adults

Authors
Cosmin Tegla1, †, Jun Choi1, †, Maher Abdul-Hay2, Frank Cirrone2, Kelli Cole2, A Samer Al-Homsi2, *
1Division of Hematology and Medical Oncology, New York University Langone Health, New York, NY, USA
2Blood and Marrow Transplantation Program, New York University Langone Health, New York, NY, USA
†

Equal first author contributors

*Corresponding author. Email: Samer.Al-Homsi@nyulangone.org
Corresponding Author
A Samer Al-Homsi
Received 18 November 2019, Accepted 7 January 2020, Available Online 28 January 2020.
DOI
10.2991/chi.d.200115.001How to use a DOI?
Keywords
GvHD prevention; Calcineurin inhibitors; mTOR inhibitors; Post-transplant cyclophosphamide
Abstract

Graft-versus-host disease (GvHD) in its acute and chronic forms continues to represent a significant barrier to the success and wide-applicability of blood and marrow transplantation as a potentially curative treatment modality for a number of benign and malignant blood conditions. Presently, calcineurin inhibitor (CNI)-based regimens remain the most commonly used prevention strategy, although post-transplant cyclophosphamide is emerging as an alternative approach, and is providing a backbone for innovative CNI-free combinations. In this paper, we review the current strategies used for the prevention of GvHD, and highlight some of the developing and promising combinations.

Copyright
© 2020 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
Clinical Hematology International
Volume-Issue
2 - 1
Pages
5 - 12
Publication Date
2020/01/28
ISSN (Online)
2590-0048
DOI
10.2991/chi.d.200115.001How to use a DOI?
Copyright
© 2020 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Cosmin Tegla
AU  - Jun Choi
AU  - Maher Abdul-Hay
AU  - Frank Cirrone
AU  - Kelli Cole
AU  - A Samer Al-Homsi
PY  - 2020
DA  - 2020/01/28
TI  - Current Status and Future Directions in Graft-Versus-Host Disease Prevention Following Allogeneic Blood and Marrow Transplantation in Adults
JO  - Clinical Hematology International
SP  - 5
EP  - 12
VL  - 2
IS  - 1
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.d.200115.001
DO  - 10.2991/chi.d.200115.001
ID  - Tegla2020
ER  -