Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)

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The Comparison of Ethanol Extract Breadfruit Leaf and Glibenclamide Towards the Decreasing of Blood Glucose Levels in Rats with Diabetes Mellitus Induced by Alloxan

Authors
Iis Inayati Rakhmat, Danial Ahmad Dzulfikri, Hadi Jusuf
Corresponding Author
Danial Ahmad Dzulfikri
Available Online 24 July 2021.
DOI
10.2991/ahsr.k.210723.006How to use a DOI?
Keywords
antidiabetic, breadfruit’s leaf, diabetes melitus, flavonoid, quercetin
Abstract

Diabetes mellitus is a disease that will increase in the future. There are many drugs used to treat this, but they have a bad side effect when they used for long term. Breadfruit’s leaf (Artocarpus altilis) is one of many plants that contains quercetin, a flavonoid that can be used as antidiabetic. This study aimed to determine the effect of ethanol extract of breadfruit’s leaf with glibenclamide on blood glucose levels rats (Rattus norvegicus). This research was conducted with experimental methods using 35 rats of wistar strain. They were divided into 5 groups, 1 group as a negative control, and 4 other groups induced by alloxan, further divided into positive control, the treatment group ethanol extract of breadfruit’s leaf, the treatment group glibenclamide, and the combination treatment group ethanol extract of breadfruit’s leaf with glibenclamid. The result statistical analysis of research by One-Way ANOVA test was significantly different after treatment (p <0.05). Then continued by Post Hoc Tukey test results showed that there were not significantly different among 3 treatment groups. In conclusion ethanol extract of breadfruit’s leaf, glibenclamide and the combination treatment group capable of lowering blood glucose levels, but there were no significant differences between three treatment groups.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)
Series
Advances in Health Sciences Research
Publication Date
24 July 2021
ISBN
10.2991/ahsr.k.210723.006
ISSN
2468-5739
DOI
10.2991/ahsr.k.210723.006How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Iis Inayati Rakhmat
AU  - Danial Ahmad Dzulfikri
AU  - Hadi Jusuf
PY  - 2021
DA  - 2021/07/24
TI  - The Comparison of Ethanol Extract Breadfruit Leaf and Glibenclamide Towards the Decreasing of Blood Glucose Levels in Rats with Diabetes Mellitus Induced by Alloxan
BT  - Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)
PB  - Atlantis Press
SP  - 24
EP  - 28
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210723.006
DO  - 10.2991/ahsr.k.210723.006
ID  - Rakhmat2021
ER  -