Simvastatin Partially Prevents Bone Loss in Tail-suspended Rat:Bone Mineral Density and Histomorphometry Analysis
Faming Tian, Xinhao Fan, Lei Xing, Zhiwei Lv
Available Online January 2014.
- https://doi.org/10.2991/ccit-14.2014.80How to use a DOI?
- Tail-suspension, Simvastatin, Bone histomorphometry, Bone mineral density, Bone formation
- Background: Skeletal unloading induces osteopenia in the loaded bones. Simvastatin, as one of the HMG-CoA reductase inhibitors for lowering lipids, has been demonstrated its potential benefit in bone formation, while no study reported whether simvastatin could prevent the bone loss in unloaded bone. Objective: We performed this study to assess the effect of simvastatin on bone mass and bone formation in tail-suspension rat. Methods: Tail-suspension rats were treated with or without simvastatin for 3 weeks, The right femurs were removed for the measurement of bone histomorphometry after bone mineral density(BMD) assessment by dual-energy X-ray absorptiometry. Results: The total bone mineral density(tBMD) and distal bone mineral density(dBMD) of tail-suspended rats were significantly lower than that of normal rat, while proximal bone mineral density(pBMD) of normal rats was significantly higher than tail-suspended rat, but no statistical difference was observed between normal and simvastatin-treatment rats. Similar to the BMD results, histomorphometric assessment for the trabeculae bone of distal femurs showed markedly higher BV/TV and lower trabecular Tb. Sp in normal rats compared to those of tail-suspended rats, while both the bone formation and bone resorption parameters were markedly increased in tail-suspended rats with or without simvastatin treatment, simvastatin showed stimulation on osteoid formation comparing to normal and tail-suspended rats. Conclusion: simvastatin treatment could partially prevent tail-suspention-induced osteoporosis in unloaded limb.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Faming Tian AU - Xinhao Fan AU - Lei Xing AU - Zhiwei Lv PY - 2014/01 DA - 2014/01 TI - Simvastatin Partially Prevents Bone Loss in Tail-suspended Rat:Bone Mineral Density and Histomorphometry Analysis BT - 2014 International Conference on Computer, Communications and Information Technology (CCIT 2014) PB - Atlantis Press SP - 306 EP - 308 SN - 1951-6851 UR - https://doi.org/10.2991/ccit-14.2014.80 DO - https://doi.org/10.2991/ccit-14.2014.80 ID - Tian2014/01 ER -