Simvastatin Partially Prevents Bone Loss in Tail-suspended Rat:Bone Mineral Density and Histomorphometry Analysis

DOI

10.2991/ccit-14.2014.80How to use a DOI?

Keywords

Tail-suspension, Simvastatin, Bone histomorphometry, Bone mineral density, Bone formation

Abstract

Background: Skeletal unloading induces osteopenia in the loaded bones. Simvastatin, as one of the HMG-CoA reductase inhibitors for lowering lipids, has been demonstrated its potential benefit in bone formation, while no study reported whether simvastatin could prevent the bone loss in unloaded bone. Objective: We performed this study to assess the effect of simvastatin on bone mass and bone formation in tail-suspension rat. Methods: Tail-suspension rats were treated with or without simvastatin for 3 weeks, The right femurs were removed for the measurement of bone histomorphometry after bone mineral density(BMD) assessment by dual-energy X-ray absorptiometry. Results: The total bone mineral density(tBMD) and distal bone mineral density(dBMD) of tail-suspended rats were significantly lower than that of normal rat, while proximal bone mineral density(pBMD) of normal rats was significantly higher than tail-suspended rat, but no statistical difference was observed between normal and simvastatin-treatment rats. Similar to the BMD results, histomorphometric assessment for the trabeculae bone of distal femurs showed markedly higher BV/TV and lower trabecular Tb. Sp in normal rats compared to those of tail-suspended rats, while both the bone formation and bone resorption parameters were markedly increased in tail-suspended rats with or without simvastatin treatment, simvastatin showed stimulation on osteoid formation comparing to normal and tail-suspended rats. Conclusion: simvastatin treatment could partially prevent tail-suspention-induced osteoporosis in unloaded limb.

Copyright

© 2014, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Faming Tian
AU  - Xinhao Fan
AU  - Lei Xing
AU  - Zhiwei Lv
PY  - 2014/01
DA  - 2014/01
TI  - Simvastatin Partially Prevents Bone Loss in Tail-suspended Rat:Bone Mineral Density and Histomorphometry Analysis
BT  - Proceedings of the 2014 International Conference on Computer, Communications and Information Technology
PB  - Atlantis Press
SP  - 306
EP  - 308
SN  - 1951-6851
UR  - https://doi.org/10.2991/ccit-14.2014.80
DO  - 10.2991/ccit-14.2014.80
ID  - Tian2014/01
ER  -