Proceedings of the International Conference on Electronics, Mechanics, Culture and Medicine

Correlation Between Genetic Factors and the Incidence of Ocular Hypertension Glaucoma / Normal Tension Glaucoma

Authors
Yali Feng, Zhe Cui, Wenshuang Xu
Corresponding Author
Yali Feng
Available Online February 2016.
DOI
https://doi.org/10.2991/emcm-15.2016.104How to use a DOI?
Keywords
Genetic factors; High tension glaucoma; Normal tension glaucoma; SNP; Polymorphism
Abstract
Objective To explore the correlation between genetic factors and incidence of primary open angle glaucoma (POAG) Method 1157 cases of patients with POAG composed by 297 NTG and 860 HTG were recruited. Genomic DNA from each case was genotyped for 13 loci of SNPs in 4 genes TMCO1, CDKN2B-AS1, ATOH7 and SIX1/SIX6. Relationship between SNP allelic frequency and the clinical indexes was calculated. Results The variation of rs4656461 and rs7555523 in TMCO1 were susceptible to the onset of POAG, while the variation of rs1063192, rs523096, rs7049105, rs2157719 in CDKN2B-AS1, rs33912345, rs10483727 in SIX1 / SIX6 related to POAG as protective factors. Variation of rs4656461 and rs7555523 in TMCO1 was susceptible to HTG, while rs523096, rs2157719 in CDKN2B-AS1 and rs33912345, rs10483727 in SIX1 / SIX6 correlated with NTG more protectively, IOP correlated with SNPs of rs523096, rs2157719 in CDKN2B-AS1 and rs33912345, rs10483727 in SIX1 / SIX6 with either multiple correction of age and gender, or Bonferroni adjustment. Conclusion The polymorphism of rs523096, rs2157719 in CDKN2B-AS1 and rs33912345, rs10483727 in SIX1 / SIX6 correlated with NTG significantly, and polymorphism of rs4656461 and rs7555523 in TMCO1 was susceptible to HTG.
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Proceedings
International Conference on Electronics, Mechanics, Culture and Medicine
Part of series
Advances in Computer Science Research
Publication Date
February 2016
ISBN
978-94-6252-163-6
ISSN
2352-538X
DOI
https://doi.org/10.2991/emcm-15.2016.104How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Yali Feng
AU  - Zhe Cui
AU  - Wenshuang Xu
PY  - 2016/02
DA  - 2016/02
TI  - Correlation Between Genetic Factors and the Incidence of Ocular Hypertension Glaucoma / Normal Tension Glaucoma
BT  - International Conference on Electronics, Mechanics, Culture and Medicine
PB  - Atlantis Press
SP  - 553
EP  - 558
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-15.2016.104
DO  - https://doi.org/10.2991/emcm-15.2016.104
ID  - Feng2016/02
ER  -