Proceedings of the 2015 International Conference on Education, Management, Information and Medicine

Synthesis and Anticancer Activity Of One Novel Thiopyrano[4,3-D]Pyrimidine Derivative Bearing A Indole-hydrazone

Authors
Chengyu Sun, Chen Chen, Shan Xu, Qingqing Hu, Pengwu Zheng, Wufu Zhu
Corresponding Author
Chengyu Sun
Available Online April 2015.
DOI
https://doi.org/10.2991/emim-15.2015.167How to use a DOI?
Keywords
Thiopyrano[4;3-D]pyrimidine; Synthesis; mTOR Inhibitors; Indole-hydrazone; Anticancer.
Abstract

A novel thiopyrano[4,3-d]pyrimidin derivative bearing a indole-hydrazone was synthesized and structure was confirmed by 1H NMR and MS. Moreover, this compound was evaluated for its cytotoxicity against the H460 cell lines and inhibitory activity against mTOR kinase at a concentration of 10uM. The result indicated that this compound exhibited moderate activity against cancer cell line as well as mTOR kinase. At 10 M level, the inhibition rate of compound 1 against H460 cell lines and mTOR kinase was 39.6% and 47.0%.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2015 International Conference on Education, Management, Information and Medicine
Series
Advances in Economics, Business and Management Research
Publication Date
April 2015
ISBN
978-94-62520-68-4
ISSN
2352-5428
DOI
https://doi.org/10.2991/emim-15.2015.167How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Chengyu Sun
AU  - Chen Chen
AU  - Shan Xu
AU  - Qingqing Hu
AU  - Pengwu Zheng
AU  - Wufu Zhu
PY  - 2015/04
DA  - 2015/04
TI  - Synthesis and Anticancer Activity Of One Novel Thiopyrano[4,3-D]Pyrimidine Derivative Bearing A Indole-hydrazone
BT  - Proceedings of the 2015 International Conference on Education, Management, Information and Medicine
PB  - Atlantis Press
SP  - 859
EP  - 862
SN  - 2352-5428
UR  - https://doi.org/10.2991/emim-15.2015.167
DO  - https://doi.org/10.2991/emim-15.2015.167
ID  - Sun2015/04
ER  -