Microwave-Assisted Efficient Synthesis of Dialkylated Ureas from Ureas

DOI

10.2991/emim-15.2015.183How to use a DOI?

Keywords

Dialkylated Ureas; Alcohols; Transition Metal; Microwave Irradiation; Synthetic Method

Abstract

Microwave irradiation provided an effective tool for rapid, clean, and high-yielding transformations of organic reactions. Despite these advances, the N-alkylation of amines with alcohols under microwave irradiation remains less unexplored. We demonstrated a general and efficient method for the synthesis of dialkylated ureas from ureas under microwave irradiation is described. Reactios of ureas with a series of alcohols, such as benzyl alcohol, benzylic alcohols bearing a electron-donating group or a electron-withdrawing group, afforded the desired dialkylated ureas with good yields at a short time. Experimental results exhibited obvious advantages of microwave irradiation.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Feng Li
AU  - Juan Ma
PY  - 2015/04
DA  - 2015/04
TI  - Microwave-Assisted Efficient Synthesis of Dialkylated Ureas from Ureas
BT  - Proceedings of the 2015 International Conference on Education, Management, Information and Medicine
PB  - Atlantis Press
SP  - 942
EP  - 945
SN  - 2352-5428
UR  - https://doi.org/10.2991/emim-15.2015.183
DO  - 10.2991/emim-15.2015.183
ID  - Li2015/04
ER  -