TATA-binding Protein (TBP) Involved in the Ecdysone Signal Pathway of Drosophila

DOI

10.2991/emim-15.2015.224How to use a DOI?

Keywords

Drosophila; Ecdysone; TBP gene; Expression profile

Abstract

The Drosophila TATA-box binding protein (TBP) is a general transcription factor required by all three eukaryotic nuclear RNA polymerases, it can recognize the TATA-box sequence to initiate gene transcription. TBP and other TATA binding factors are spatio-temporal control of gene expression in different tissue types or in different stages of development. However, how the TBP gene is mediated is still elusive. This study reveals that TBP expression increased at molting and metamorphosis stage, 20-hydroxyecdysone (20E) can induce TBP expression, and the silence of EcR-A and USP1 led to a reduced transcript level of TBP in S2 cells. These results indicate that the TBP gene involved in the 20E signaling transduction pathway, and it acts downstream EcR and its heterodimer USP.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Gang Wang
PY  - 2015/04
DA  - 2015/04
TI  - TATA-binding Protein (TBP) Involved in the Ecdysone Signal Pathway of Drosophila
BT  - Proceedings of the 2015 International Conference on Education, Management, Information and Medicine
PB  - Atlantis Press
SP  - 1138
EP  - 1142
SN  - 2352-5428
UR  - https://doi.org/10.2991/emim-15.2015.224
DO  - 10.2991/emim-15.2015.224
ID  - Wang2015/04
ER  -