Proceedings of the 6th International Conference of Food, Agriculture, and Natural Resource (IC-FANRES 2021)

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Evaluation of the Ethyl Acetate Extract of the Roots of Avicennia marina as Potential Anticancer Drug

Authors
Immanuel B. Tanjung1, Norma N. Azizah2, Ade Arsianti2, Amalda S Anisa3, Kholis A Audah1, 4, *
1Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia
2Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia
3Department of Chemistry, IPB University, Bogor, 16680, Indonesia
4Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia
*Corresponding author. Email: audahka@gmail.com
Corresponding Author
Kholis A Audah
Available Online 5 January 2022.
DOI
10.2991/absr.k.220101.011How to use a DOI?
Keywords
Antioxidants; Avicennia marina; Bioactive; Cancer; MTT assay
Abstract

In this modern age cancer is still a prevalent disease. Even with advancements of technology, current treatments for cancer still have various side-effects that sometimes create more harm to the patient. A complete solution for cancer is still not found yet. Recently, mangroves were shown to be promising sources of new drugs. The species Avicennia marina was suggested to be anti-cancerous, thus it could be a potential anticancer drug. This study was conducted to evaluate the viability of A. marina root ethyl acetate extract as a possible anticancer drug, and to determine whether its anticancer mechanisms are by counteracting the reactive oxygen species as an antioxidant. The extract was subjected to total phenolic and flavonoid content tests, to determine the bioactive compounds, which are thought to be directly related to antioxidant activities. The DPPH method was used to evaluate the antioxidant activity of the extract. Brine shrimp (Artemia salina) was subjected to the extract to determine its toxicity, and determined its anticancer properties against cancer cell lines HT29 (colon), HeLa (cervix) and T47D (breast) by MTT Assay. Results showed that the extract has moderate amounts of phenolic and flavonoids, moderate antioxidant activity, not toxic to normal cells but toxic towards cancer cells.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the 6th International Conference of Food, Agriculture, and Natural Resource (IC-FANRES 2021)
Series
Advances in Biological Sciences Research
Publication Date
5 January 2022
ISBN
10.2991/absr.k.220101.011
ISSN
2468-5747
DOI
10.2991/absr.k.220101.011How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - Immanuel B. Tanjung
AU  - Norma N. Azizah
AU  - Ade Arsianti
AU  - Amalda S Anisa
AU  - Kholis A Audah
PY  - 2022
DA  - 2022/01/05
TI  - Evaluation of the Ethyl Acetate Extract of the Roots of Avicennia marina as Potential Anticancer Drug
BT  - Proceedings of the 6th International Conference of Food, Agriculture, and Natural Resource (IC-FANRES 2021)
PB  - Atlantis Press
SP  - 75
EP  - 81
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.220101.011
DO  - 10.2991/absr.k.220101.011
ID  - Tanjung2022
ER  -