Potential of Dendrobium spp. Secondary Metabolites as Medicinal Source for SARS-CoV-2

Muhamad Rafli; Tri Rohmiati; Anggiresti Kinasih; Alim El Hakim; Endang Semiarti

doi:10.2991/absr.k.220406.059

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Potential of Dendrobium spp. Secondary Metabolites as Medicinal Source for SARS-CoV-2

Authors

Muhamad Rafli¹, Tri Rohmiati¹, Anggiresti Kinasih¹, Alim El Hakim¹, Endang Semiarti¹^{, *}

¹Department of Tropical Biology, Faculty of Biology, Universitas Gadjah Mada, Jl. Teknika Selatan, Sekip Utara, Sleman, 55281, Special Region of Yogyakarta

^*Corresponding author. Email: endsemi@ugm.ac.id

Corresponding Author

Endang Semiarti

Available Online 2 May 2022.

DOI: 10.2991/absr.k.220406.059 How to use a DOI?
Keywords: Dendrobium; In silico COVID 19; Secondary metabolite
Abstract: Coronaviruses have long been a severe issue due to their capacity to mutate and infect the respiratory tract. Dendrobium orchids are the most diverse orchid species in Indonesia. Polysaccharides, bibenzyl, phenanthrene, coumarin, sesquiterpenoids, alkaloids, and steroids were among the phytochemical substances discovered in Dendrobium spp. On a group of alkaloids, flavonoid, and terpenoid, Dendrobium’s anti-coronavirus action has been thoroughly researched in silico, in vitro, and in vivo. Secondary metabolites were evaluated on methanolic extracts of Dendrobium phalaenopsis and Dendrobium lineale leaves in this study. In a computer simulation, antiviral activity against SARS-CoV-2 was also discovered. Thin-layer chromatography (TLC) was used to determine the concentration of alkaloids, flavonoids, and terpenoids in dried leaf extracts of D. phalaenopsis and D. lineale. The online Covid-19 Docking Server (https://ncov.schanglab.org.cn/index.php) was used as an autodocking molecular docking tool to find potential secondary metabolites of Dendrobium spp. as SARS-CoV-2 antiviral. Screening of the leaves of Dendrobium phalaenopsis and Dendrobium lineale using methanolic extracts revealed positive results for alkaloid, flavonoid, and terpenoid content. According to the results of molecular docking, Medioresinol, (+)-Lirioresinol B, Acanthoside B, Dendrocandin B, Denthyrsinone, and Dendroside D had the lowest affinity energy.
Copyright: © 2022 The Authors. Published by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license.

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Volume Title: Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
Series: Advances in Biological Sciences Research
Publication Date: 2 May 2022
ISBN: 10.2991/absr.k.220406.059
ISSN: 2468-5747
DOI: 10.2991/absr.k.220406.059 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license.

Cite this article

ris enw bib

TY  - CONF
AU  - Muhamad Rafli
AU  - Tri Rohmiati
AU  - Anggiresti Kinasih
AU  - Alim El Hakim
AU  - Endang Semiarti
PY  - 2022
DA  - 2022/05/02
TI  - Potential of Dendrobium spp. Secondary Metabolites as Medicinal Source for SARS-CoV-2
BT  - Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
PB  - Atlantis Press
SP  - 424
EP  - 430
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.220406.059
DO  - 10.2991/absr.k.220406.059
ID  - Rafli2022
ER  -

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