Anti-Inflammatory Effects of Kaempferia galanga L. Rhizome Extract in Carrageenan-Induced Female Rats
- DOI
- 10.2991/ahsr.k.200204.004How to use a DOI?
- Keywords
- Kaempferia galanga L, anti-inflammatory, carrageenan
- Abstract
Kencur (Kaempferiae galanga L.) is a plant that is traditionally used for the treatment of various diseases including inflammation. This study aimed to know the comparison of the effectiveness of kencur extracts with diclofenac sodium as an antiinflammatory agent. Fifteen female rats aged 2-3 months (200250 gram) were divided into 5 groups: rats in negative control group only given a 2% suspension of PGA, rats in positive control group given 20 mg/Kg diclofenac sodium, and rats in three different dose groups given galanga rhizomes extract of 45, 90, and 180 mg/Kg, respectively. All drugs were given 1 hour orally before carrageenan injection of 1% as induction of edema. Edema volume was measured every 30 minutes to 390 minutes to calculate the percentage of edema inhibition. The data were analyzed using one-way ANOVA and followed by LSD test to see differences among groups. Ethanol extract of galanga rhizome in the 5th hour at doses of 45, 90 and 180 mg/kg showed significant differences in a positive control group. Each Sig. value was 0.002; 0.004; 0.002. This showed that the ethanol extract of kencur had anti-inflammatory activity at all dose levels.
- Copyright
- © 2020, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Galih Samodra AU - Dina Febrina PY - 2020 DA - 2020/02/10 TI - Anti-Inflammatory Effects of Kaempferia galanga L. Rhizome Extract in Carrageenan-Induced Female Rats BT - Proceedings of the 1st International Conference on Community Health (ICCH 2019) PB - Atlantis Press SP - 13 EP - 17 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.200204.004 DO - 10.2991/ahsr.k.200204.004 ID - Samodra2020 ER -