The Effect of Black Pepper Fruits (Piper nigrum L.) on the Increase of Erection

DOI

10.2991/ahsr.k.200204.054How to use a DOI?

Keywords

black pepper, erection, testosterone, androgen receptor

Abstract

Erectile dysfunction is the one of male sexual problems. Testosterone stimulate erection process physiologically. The study showed that black pepper extract increased sexual performance and testosterone level in animal research. The purpose of this study was to know the erotogenic effect, testosterone serum and concentration of brain androgen receptor of ethanolic extract of black pepper fruits. 25 adult male Wistar rats were divided into 5 groups: Na-CMC orally, TU/testosterone undecanoate (Andriol® Testocaps™) 4 mg/kg of body weight (BW) orally, the three groups were given of ethanolic extract of P. nigrum 3.33 mg, 6.66 mg and 13.32 mg/kg BW respectively for 55 days. Penile rat erection were observed by Total Penile Reflex (TPR). The measurement of testosterone serum and brain androgen receptor concentration used was ELISA method. Erection capability in the TU, P. nigrum 3.33 mg, 6.66 mg and 13.32 mg groups were increased until the 5th week observation and decreased after that. Na-CMC group erection capability increased gradually from 1st week until 8th week observation. Testosterone level in the Na-CMC and P. nigrum 6.66 mg decrease continually in the 4th and 8th week measurement. In TU group, P. nigrum 3.33 mg and 13.32 mg groups of testosterone level were increased in the 4th week and decreased in the 8th week. Brain androgen receptor concentration of the TU, P. nigrum 3.33 mg, 6.66 mg and 13.32 mg groups were lower than Na-CMC group. Extract of black pepper fruit had erotogenic effect on the increase of testosterone level of male Wistar rats.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Nandia Septiyorini
AU  - Setyo Purwono
AU  - Dicky Moch Rizal
PY  - 2020
DA  - 2020/02/10
TI  - The Effect of Black Pepper Fruits (Piper nigrum L.) on the Increase of Erection
BT  - Proceedings of the 1st International Conference on Community Health (ICCH 2019)
PB  - Atlantis Press
SP  - 251
EP  - 255
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200204.054
DO  - 10.2991/ahsr.k.200204.054
ID  - Septiyorini2020
ER  -