The Effect of Black Pepper Fruits (Piper nigrum L.) on the Increase of Erection
Nandia Septiyorini, Setyo Purwono, Dicky Moch Rizal
Available Online 10 February 2020.
- https://doi.org/10.2991/ahsr.k.200204.054How to use a DOI?
- black pepper, erection, testosterone, androgen receptor
- Erectile dysfunction is the one of male sexual problems. Testosterone stimulate erection process physiologically. The study showed that black pepper extract increased sexual performance and testosterone level in animal research. The purpose of this study was to know the erotogenic effect, testosterone serum and concentration of brain androgen receptor of ethanolic extract of black pepper fruits. 25 adult male Wistar rats were divided into 5 groups: Na-CMC orally, TU/testosterone undecanoate (Andriol® Testocaps™) 4 mg/kg of body weight (BW) orally, the three groups were given of ethanolic extract of P. nigrum 3.33 mg, 6.66 mg and 13.32 mg/kg BW respectively for 55 days. Penile rat erection were observed by Total Penile Reflex (TPR). The measurement of testosterone serum and brain androgen receptor concentration used was ELISA method. Erection capability in the TU, P. nigrum 3.33 mg, 6.66 mg and 13.32 mg groups were increased until the 5th week observation and decreased after that. Na-CMC group erection capability increased gradually from 1st week until 8th week observation. Testosterone level in the Na-CMC and P. nigrum 6.66 mg decrease continually in the 4th and 8th week measurement. In TU group, P. nigrum 3.33 mg and 13.32 mg groups of testosterone level were increased in the 4th week and decreased in the 8th week. Brain androgen receptor concentration of the TU, P. nigrum 3.33 mg, 6.66 mg and 13.32 mg groups were lower than Na-CMC group. Extract of black pepper fruit had erotogenic effect on the increase of testosterone level of male Wistar rats.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Nandia Septiyorini AU - Setyo Purwono AU - Dicky Moch Rizal PY - 2020 DA - 2020/02/10 TI - The Effect of Black Pepper Fruits (Piper nigrum L.) on the Increase of Erection PB - Atlantis Press SP - 251 EP - 255 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.200204.054 DO - https://doi.org/10.2991/ahsr.k.200204.054 ID - Septiyorini2020 ER -