Role of the Cortisol Hormone, Interleukin-5 Level, and Asthma Control Ability in Atopy Persistent Asthma

DOI

10.2991/ahsr.k.200204.010How to use a DOI?

Keywords

atopy persistent asthma, asthma control ability, cortisol hormone, interleukin- 5

Abstract

Introduction: Asthma is a chronic inflammatory disorder of the respiratory tract. The interaction among several hormones and mediators causes asthma symptoms. This study aimed to identify a correlation between the cortisol hormone, interleukin-5 level, and asthma control in asthma atopy persistent. Materials and Methods: 39 atopic participants of asthma group and 26 participants of non-asthma group were taken from the medical record in Prof. Dr. Margono Soekarjo Purwokerto hospital Central Java Indonesia. Peripheral blood mononuclear cells were isolated 72 hours with house dust mite allergens stimulation. Plasma levels of cortisol hormone and interleukin-5 were measured using an enzyme-linked immunosorbent assay kit. The ability to control symptoms was assessed using the Asthma Control Questionnaire. Results and Conclusions: Based on statistical analysis the results showed that there were differences between cortisol levels of asthma and non-asthmatic groups (p=0.001), there was correlation cortisol hormone with interleukin-5 stimulation of house dust mites allergens (p=0.04), there was no correlation interleukin-5 stimulation of house dust mite with asthma control ability (p=0.42), and there was no correlation between the hormone cortisol and asthma control ability (p=0.38). Therefore, cortisol hormone healthy subject was higher than asthma subject and thus there was correlation of cortisol hormone and interleukin-5 house dust mite allergens, and there were no correlation interleukin-5 house dust mite allergens and cortisol hormone with asthma control ability.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Rahmaya Nova
AU  - Faisal Yunus
AU  - Ermita Isfandiary
AU  - Iris Rengganis
PY  - 2020
DA  - 2020/02/10
TI  - Role of the Cortisol Hormone, Interleukin-5 Level, and Asthma Control Ability in Atopy Persistent Asthma
BT  - Proceedings of the 1st International Conference on Community Health (ICCH 2019)
PB  - Atlantis Press
SP  - 40
EP  - 44
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200204.010
DO  - 10.2991/ahsr.k.200204.010
ID  - Nova2020
ER  -