Immunomodulator Effect Test of Sungkai Leaves (Peronema canescsens Jack.) Ethanol Extract Using Carbon Clearance Method

DOI

10.2991/ahsr.k.211105.001How to use a DOI?

Keywords

Peronema canescens Jack; Immunomodulator; Immunostimulant; Carbon Clearance; Leukocytes

Abstract

Sungkai leaf extract (Peronema canescens Jack.) has been used traditionally to cure various diseases for humans. This research aimed to determine the immunostimulant effect of sungkai leaf extract using the carbon clearance method, the total of leukocyte cells, and the percentage of leukocyte cell types. 25 male mice were divided into 5 groups. The extract was administered orally for 6 days at a dose of 25; 50; 100 mg/kgbw, Na CMC 0.5% as control and Stimuno 50 mg/kgbw as a comparison. The phagocytic index, total leukocytes, and the percentage of leukocyte cell types are determined on the 7th day. The phagocytosis index value was statistically analyzed by one-way ANOVA followed by Duncan’s test. The increase of phagocytosis index showed that the effect of each dose was significantly different (P < 0.05) with Na CMC 0.5% as control. The highest phagocytosis index was obtained from a dose of 100 mg/kgbw. Based on the one-way ANOVA test continued by Duncan’s test, there was a significant difference (p<0.05) in the total leukocyte cell and the percentage of leukocyte cell type. Sungkai leaf extract (Peronema canescens Jack.) had an immunostimulant effect on male white mice (Mus musculus L.).

Copyright

© 2021 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Dwisari Dillasamola
AU  - Yufri Aldi
AU  - Hendra Kurniawan
AU  - Ilza Millenia Jalius
PY  - 2021
DA  - 2021/11/17
TI  - Immunomodulator Effect Test of Sungkai Leaves (Peronema canescsens Jack.) Ethanol Extract Using Carbon Clearance Method
BT  - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021)
PB  - Atlantis Press
SP  - 1
EP  - 6
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211105.001
DO  - 10.2991/ahsr.k.211105.001
ID  - Dillasamola2021
ER  -