Stimulant Activity of Arabica Coffee Leaves (Coffea arabica L.) and Clove Flowers (Syzygium aromaticum (L.) Merr. & L.M. Perry) Ethanol Extract Mixture in Male White Mice
- DOI
- 10.2991/ahsr.k.211105.051How to use a DOI?
- Keywords
- Stimulant effect; Coffea Arabica; Syzygium aromaticum; Central nervous system
- Abstract
Arabica coffee leaves and clove flowers are some of the plants that are used as traditional medicine. Both of these plants are known to have secondary metabolites that have stimulant activity. This study aims to determine the stimulant activity of a combination of coffee leaf extract (Coffea arabica L.) and clove flower (Syzygium aromaticum (L.) Merr. & L. M.Perry). This study used 35 male white mice divided into seven groups. Normal groups, control group caffeine 13 mg/kg BW; coffee leaf extract 400 mg/kg BW; clove flower extract 400 mg/kg BW and a combination of coffee leaf extract and clove flower 300 mg/kg BW: 100 mg/kg BW; 200 mg/kg BW: 200 mg/kg BW; 100 mg/kg BW: 300 mg/kg BW orally. All treatments to mice were carried out for 15 days. The stimulant activity was tested on days 5, 10, and 15. The parameters of the stimulant activity observed were motor and sensory activity using an Automatic hole board, endurance using Tail Suspension Test, and memory using a T-Maze. The results showed that the best stimulant activity for motor, sensory, and endurance was given by a combination of coffee leaf extract: clove flower 300 mg:100 mg (P<0.05). The best stimulant activity for memory was given by a combination of coffee leaf extract: clove flower 100 mg:300 mg (P<0.05).
- Copyright
- © 2021 The Authors. Published by Atlantis Press International B.V.
- Open Access
- This is an open access article under the CC BY-NC license.
Cite this article
TY - CONF AU - Rahmad Abdillah AU - Helmi Arifin AU - Fitri Rachmaini AU - Melda Guswita PY - 2021 DA - 2021/11/17 TI - Stimulant Activity of Arabica Coffee Leaves (Coffea arabica L.) and Clove Flowers (Syzygium aromaticum (L.) Merr. & L.M. Perry) Ethanol Extract Mixture in Male White Mice BT - Proceedings of the 2nd International Conference on Contemporary Science and Clinical Pharmacy 2021 (ICCSCP 2021) PB - Atlantis Press SP - 350 EP - 356 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.211105.051 DO - 10.2991/ahsr.k.211105.051 ID - Abdillah2021 ER -