The Experimental Study of the Influence of Yanlingdan Prescription on the Apoptosis Protein Fas/FasL Expression of Ovarian Granular Cells in Mice with Premature Ovarian Failure
Wang Yang, Li PengHui, Li CuiPing, Wang Bin, Niu ShuDong, Wen LiBo, Zhao Kun, Wang Yuge, Wang Yuefei
Available Online June 2016.
- https://doi.org/10.2991/icemc-17.2017.49How to use a DOI?
- Yanlingdan prescription; Granular cells; Apoptosis proteins; FAS; FASL
- Objective: The purpose of this research is to observe the influence of Yanlingdan prescription on the apoptosis protein Fas/FasL expression of ovarian granular cells in mice with autoimmune premature ovarian failure and investigate the mechanism of this prescription in the treatment of premature ovarian failure. Method: Taking the Zona pellucida3 of mice as the antigen, the female mice were injected subcutaneously with this drug to make mice immune so as to become the mice with premature ovarian failure. Blank control group, model group, Yanlingdan group and western medicine group are set. After two weeks of dosing mice, we use immunohistochemical method to detect the expression level of apoptosis related protein Fas/FasL of ovarian granular cells. Results:The expression level of apoptosis related protein Fas/FasL in model group is obviously higher than the blank control group (P<0.01). Compared with model group, the FAS and FASL protein expression of mice' follicle in Yanlingdan group and western medicine group weakens obviously (P<0.01). When the expression of Fas and Fasl in Yanlingdan group compares with the normal control group, the difference has no statistical significance (P>0.05). Conclusion: Yanlingdan prescription can effectively suppress the expression of FAS/FASL protein of follicular granular cells and have inhibitory effects on the apoptosis of ovarian granular cells in mice with premature ovarian failure.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Wang Yang AU - Li PengHui AU - Li CuiPing AU - Wang Bin AU - Niu ShuDong AU - Wen LiBo AU - Zhao Kun AU - Wang Yuge AU - Wang Yuefei PY - 2016/06 DA - 2016/06 TI - The Experimental Study of the Influence of Yanlingdan Prescription on the Apoptosis Protein Fas/FasL Expression of Ovarian Granular Cells in Mice with Premature Ovarian Failure BT - Proceedings of the 7th International Conference on Education, Management, Information and Computer Science (ICEMC 2017) PB - Atlantis Press SP - 246 EP - 249 SN - 2352-538X UR - https://doi.org/10.2991/icemc-17.2017.49 DO - https://doi.org/10.2991/icemc-17.2017.49 ID - Yang2016/06 ER -