Proceedings of the 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017)

Burn Healing with Binahong (Anredera cordifolia (Tenore) Steenis) Leaves Extract as A Topical and Systemic Treatments

Authors
A.F. Hapsari, D.A.W. Setyaningrum, R.P. Wardhani, A. Alfina, W.A. Dzakiy, R.B. Ginting, M.F. Fajriansyah
Corresponding Author
A.F. Hapsari
Available Online December 2017.
DOI
https://doi.org/10.2991/ichlas-17.2017.2How to use a DOI?
Keywords
Binahong leaves extract; Anredera cordifolia (Ten.) Steenis; burn healing;topical treatment; systemic treatment
Abstract
Burn is still an important problem in health facility worldwide. Burns management from ancients ago until now is quite varied either giving topical therapy alone or combination with systemic drug along with various clinical considerations. Research on the healing of burns with phytoextract has been done in the last 20 years. Binahong leaves or Anredera Cordifolia (Tenore) Steenis is one of the most studied phytoextract for wounds, but lack on burns research. Previous studies in this leaf ethanol extract showed that 40% concentration is the most effective on wound healing. Describes the effect of binahong 40% leaves ethanolic extract in the formation of reepithelialization, neo-vascularization, fibroblasts, and the density of collagen as part of healing process on post second degree burns of the skin as topical and systemic/oral treatments. Experimental study on 25 Sprague dawleys that divided into 5 groups. Group I was treated with ointment of binahong 40% leaves ethanolic extract, group II was treated with oral preparation of binahong leaves ethanolic extract 100mg/kg body weight, group III was treated with combination of binahong 40% leaves ethanolic extract both topical and oral preparations, group IV was treated with a silver sulfadiazine ointment (positive control), and group V was treated with ointment base (negative control). Treatment was started after second-degree burns created on each rat for 6 days. Burns site excised after six days of treatments, prepared for paraffin embedded and HE staining to examine tissue reepitelialization, neo-vascularisations, fibroblast count, collagen formation, and inflammatory cell formation using light microscope. There was no significant difference in the process of reepithelialization, neo-vascularization, the amount of fibroblasts, among five groups (p> 0.05). While the lowest inflammatory cells and the density of collagen were best seen in the 40% extract ointment group with p = 0, 0001 and p = 0.037 (p<0.05). The process of burns healing with topical and oral binahong extracts did not show any significant difference, but topical administration was able to suppress the number of inflammatory cells and increase collagen formation more effective than sistemic/oral treatments alone.
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Proceedings
1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017)
Part of series
Advances in Health Sciences Research
Publication Date
December 2017
ISBN
978-94-6252-422-4
ISSN
2468-5739
DOI
https://doi.org/10.2991/ichlas-17.2017.2How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - A.F. Hapsari
AU  - D.A.W. Setyaningrum
AU  - R.P. Wardhani
AU  - A. Alfina
AU  - W.A. Dzakiy
AU  - R.B. Ginting
AU  - M.F. Fajriansyah
PY  - 2017/12
DA  - 2017/12
TI  - Burn Healing with Binahong (Anredera cordifolia (Tenore) Steenis) Leaves Extract as A Topical and Systemic Treatments
BT  - 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017)
PB  - Atlantis Press
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichlas-17.2017.2
DO  - https://doi.org/10.2991/ichlas-17.2017.2
ID  - Hapsari2017/12
ER  -