Research of Ofloxacin Based on Terahertz Spectrum

DOI

10.2991/icmmita-16.2016.267How to use a DOI?

Keywords

Terahertz time-domain spectroscopy; Absorption spectrum; Density functional theory; Ofloxacin

Abstract

The absorption coefficient, refractive index and optical fingerprint characteristics were acquired by terahertz time-domain spectroscopy in the range of 0.4~1.5THz of the capsule drug ofloxacin. The results show that ofloxacin had multiple absorption peaks with different intensities within the frequency range, and the absorption coefficient spectrum could be used for the identification of ofloxacin. In the range of 0.4~1.5THz,the absorption spectra of ofloxacin molecules were simulated by Gaussion software. The vibration modes of some absorption peaks in the absorption spectra were analyzed and identified using the density functional theory. At 1.06 and 1.13THz, the experimental results show that the absorption peaks are consistent with the absorption peaks of 1.07 and 1.18THz in the theoretical spectrum, which are caused by the vibrational modes in the molecule ofloxacin.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Song Zhang
AU  - Xiai Chen
AU  - Xiaohong Gu
AU  - Qiang Wang
AU  - Ling Wang
PY  - 2017/01
DA  - 2017/01
TI  - Research of Ofloxacin Based on Terahertz Spectrum
BT  - Proceedings of the 2016 4th International Conference on Machinery, Materials and Information Technology Applications
PB  - Atlantis Press
SP  - 1146
EP  - 1149
SN  - 2352-538X
UR  - https://doi.org/10.2991/icmmita-16.2016.267
DO  - 10.2991/icmmita-16.2016.267
ID  - Zhang2017/01
ER  -