The Effect of Platelet-Rich Plasma (PRP)-Incorporated Synthetic Coral Scaffold to the Cessation of Bleeding

DOI

10.2991/978-94-6463-070-1_52How to use a DOI?

Keywords

Synthetic coral scaffold; Incorporation; Platelet-rich plasma; Time of bleeding cessation

Abstract

Bleeding is a normal body response after tooth extraction. Bleeding can be detrimental if occurs excessively. Excessive bleeding after dental treatment may result in shock, syncope, or even death if not treated properly. Hence, effective hemostatic agents are needed to prevent excessive bleeding. Various types of hemostatic agents have been developed by researchers and used by practitioners. The purpose of this study was to examine the effect of platelet-rich plasma (PRP)-incorporated synthetic coral scaffold to the time of bleeding cessation in Rattus norvegicus. This study employed posttest design to see the results of the treatment. There were four treatment groups: (a) Spongostan®, (b) PRP-incorporated synthetic coral scaffold, (c) synthetic coral scaffold, and (d) control (without hemostatic agent). Each group consisted of seven rats. Rat’s tail was excised 2 cm from the tip, and then given treatment accordingly. Time of bleeding cessation was measured using a stopwatch, starting from the first drop of blood until blood was no longer spotted on filter paper. The results showed that PRP-incorporated synthetic coral scaffold group had the shortest cessation time (177.33 s), followed by Spongostan® (276 s) and only scaffold groups (314.67 s). Control group was the slowest (387.83 s). There was a significant difference between the control group and PRP-incorporated synthetic coral scaffold group (p = 0.033), but not significant with Spongostan® (p = 0.403) and only scaffold groups (p = 0.726). PRP-incorporated synthetic coral scaffold had the ability to reduce the time of bleeding cessation.

Copyright

© 2022 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Erlina Sih Mahanani
AU  - Ratih Sekar Arum
AU  - Anisya Nur Nova Istiyani
PY  - 2022
DA  - 2022/12/26
TI  - The Effect of Platelet-Rich Plasma (PRP)-Incorporated Synthetic Coral Scaffold to the Cessation of Bleeding
BT  - Proceedings of the International Conference on Sustainable Innovation on Health Sciences and Nursing (ICOSI-HSN 2022)
PB  - Atlantis Press
SP  - 411
EP  - 418
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-070-1_52
DO  - 10.2991/978-94-6463-070-1_52
ID  - Mahanani2022
ER  -