Proceedings of the 2014 International Conference on Mechatronics, Control and Electronic Engineering

Biological evaluation of PRGD/PDLLA for nerve regeneration scaffold

Authors
Zhu Zhang, Jiling Yi, Xiaopei Wu, Qiongjiao Yan, Yixia Yin, Shipu Li
Corresponding Author
Zhu Zhang
Available Online March 2014.
DOI
https://doi.org/10.2991/mce-14.2014.140How to use a DOI?
Keywords
Schwann cells; PRGD/PDLLA; Implantation; Inflammatory factors; Biocompatibility
Abstract
Objective: To develop a novel scaffold for nerve regeneration and explore its biocompatibility through culturing Schwann cells (SCs) on it an in vivo implantation. Methods: A novel scaffold of PDLLA with arginine–glycine–aspartic acid (RGD) peptide (PRGD/PDLLA) was synthesized.The proliferation of Schwann cells (SCs) concultured with PDLLA films (control group) and PRGD/PDLLA films were evaluated by MTT assay and scanning electron microscope observation. Then, histological assessment and ELISA testing on inflammatory-related cytokines TGF- 1 were performed. Results: compared with PDLLA, PRGD/PDLLA films possesses better hydrophilicity biocompatibility, degradation property and less inflammatory reaction. Conclusion: The present study indicated that PRGD/PDLLA scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.
Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)

Proceedings
2014 International Conference on Mechatronics, Control and Electronic Engineering (MCE-14)
Part of series
Advances in Intelligent Systems Research
Publication Date
March 2014
ISBN
978-94-62520-31-8
ISSN
1951-6851
DOI
https://doi.org/10.2991/mce-14.2014.140How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Zhu Zhang
AU  - Jiling Yi
AU  - Xiaopei Wu
AU  - Qiongjiao Yan
AU  - Yixia Yin
AU  - Shipu Li
PY  - 2014/03
DA  - 2014/03
TI  - Biological evaluation of PRGD/PDLLA for nerve regeneration scaffold
BT  - 2014 International Conference on Mechatronics, Control and Electronic Engineering (MCE-14)
PB  - Atlantis Press
SP  - 629
EP  - 632
SN  - 1951-6851
UR  - https://doi.org/10.2991/mce-14.2014.140
DO  - https://doi.org/10.2991/mce-14.2014.140
ID  - Zhang2014/03
ER  -