Biological evaluation of PRGD/PDLLA for nerve regeneration scaffold
Zhu Zhang, Jiling Yi, Xiaopei Wu, Qiongjiao Yan, Yixia Yin, Shipu Li
Available Online March 2014.
- https://doi.org/10.2991/mce-14.2014.140How to use a DOI?
- Schwann cells; PRGD/PDLLA; Implantation; Inflammatory factors; Biocompatibility
- Objective: To develop a novel scaffold for nerve regeneration and explore its biocompatibility through culturing Schwann cells (SCs) on it an in vivo implantation. Methods: A novel scaffold of PDLLA with arginine–glycine–aspartic acid (RGD) peptide (PRGD/PDLLA) was synthesized.The proliferation of Schwann cells (SCs) concultured with PDLLA films (control group) and PRGD/PDLLA films were evaluated by MTT assay and scanning electron microscope observation. Then, histological assessment and ELISA testing on inflammatory-related cytokines TGF- 1 were performed. Results: compared with PDLLA, PRGD/PDLLA films possesses better hydrophilicity biocompatibility, degradation property and less inflammatory reaction. Conclusion: The present study indicated that PRGD/PDLLA scaffolds would meet the requirements of artificial nerve scaffold and have a potential application in the fields of nerve regeneration.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Zhu Zhang AU - Jiling Yi AU - Xiaopei Wu AU - Qiongjiao Yan AU - Yixia Yin AU - Shipu Li PY - 2014/03 DA - 2014/03 TI - Biological evaluation of PRGD/PDLLA for nerve regeneration scaffold BT - 2014 International Conference on Mechatronics, Control and Electronic Engineering (MCE-14) PB - Atlantis Press SP - 629 EP - 632 SN - 1951-6851 UR - https://doi.org/10.2991/mce-14.2014.140 DO - https://doi.org/10.2991/mce-14.2014.140 ID - Zhang2014/03 ER -