Lipase Catalyzed Synthesis of High Optical Purity (S) - Naproxen Starch Ester

DOI

10.2991/meici-15.2015.78How to use a DOI?

Keywords

Naproxen Starch Ester; Synthesis; Optical Purity; Candida Rugosa Lipase

Abstract

The high optical purity naproxen starch ester has been synthesized by Candida rugosa lipase (CRL) in isooctane. The starch was treated with Urea /NaOH / H2O solution at low temperature to improve its chemical reactivity. Under the reaction condition that the ratio of racemic naproxen methyl ester to activation corn starch was 1:1, the amount of CRL was 10%(w/w), the reaction temperature was 65 , the stirred speed was 100r/min, , and the reaction time was 144 hours. The conversion of acemic naproxen methyl ester was 8.01% and the enantiomeric excess of the product (eep) was high to 96.01%. The production could be used as prodrug.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Jiaqi Yu
AU  - Jiaying Xin
PY  - 2015/06
DA  - 2015/06
TI  - Lipase Catalyzed Synthesis of High Optical Purity (S) - Naproxen Starch Ester
BT  - Proceedings of the 2015 International Conference on Management, Education, Information and Control
PB  - Atlantis Press
SP  - 439
EP  - 443
SN  - 1951-6851
UR  - https://doi.org/10.2991/meici-15.2015.78
DO  - 10.2991/meici-15.2015.78
ID  - Yu2015/06
ER  -