Proceedings of the Malang International Conference in Medical and Health Sciences (MICROMEDHS 2024)

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Development of Recombinant Epitope-Based Peptide Vaccine Of Hepatitis B Virus: In Silico Study

Authors
Kiky Martha Ariesaka1, Dwi Wahyu Wijayanto2, Arif Ladika Wiratama1, Moh Mirza Nuryady2, 3, *
1Universitas Negeri Malang, Malang, Indonesia
2Universitas Muhammadiyah Malang, Malang, Indonesia
3University of Veterinary Medicine Vienna, Vienna, Austria
*Corresponding author. Email: mirzanuryady@umm.ac.id
Corresponding Author
Moh Mirza Nuryady
Available Online 17 September 2025.
DOI
10.2991/978-94-6463-807-3_3How to use a DOI?
Keywords
Hepatitis B; Epitope-based vaccine; peptide; immunoinformatics
Abstract

Hepatitis B virus was first discovered by Blumberg and colleagues in 1965. The spread of Hepatitis B disease is alarming. The World Health Organization (WHO) in 2002 estimated that one billion living individuals have been infected with Hepatitis B, with 1–2 million deaths attributed to this virus, which attacks liver cells. Therefore, a vaccine is needed to address Hepatitis B virus disease. This study utilizes the Hepatitis B e-antigen in complex with scFv e13 with the code 6CVK. The virus has been inserted with the fusion protein scFv e13 antibody, obtained through the web server https://www.rcsb.org/. B-cell epitopes were identified using the IEDB immune epitope database web server. The results of this study recommend the peptides TLTSGVPSRFKGSGSGTE and SDTSTDTAFGGG as vaccine candidates to combat diseases caused by the Hepatitis B virus. Further studies are recommended to confirm this through in vivo and in vitro approaches.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the Malang International Conference in Medical and Health Sciences (MICROMEDHS 2024)
Series
Advances in Health Sciences Research
Publication Date
17 September 2025
ISBN
978-94-6463-807-3
ISSN
2468-5739
DOI
10.2991/978-94-6463-807-3_3How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Kiky Martha Ariesaka
AU  - Dwi Wahyu Wijayanto
AU  - Arif Ladika Wiratama
AU  - Moh Mirza Nuryady
PY  - 2025
DA  - 2025/09/17
TI  - Development of Recombinant Epitope-Based Peptide Vaccine Of Hepatitis B Virus: In Silico Study
BT  - Proceedings of the Malang International Conference in Medical and Health Sciences (MICROMEDHS 2024)
PB  - Atlantis Press
SP  - 31
EP  - 38
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-807-3_3
DO  - 10.2991/978-94-6463-807-3_3
ID  - Ariesaka2025
ER  -