Effectiveness of Evodiamine and Evodone as Ovarian Anticancer In Silico
- DOI
- 10.2991/snk-19.2019.4How to use a DOI?
- Keywords
- Evodiamine, Evodone Anticancer, Ovarian, in silico
- Abstract
Cancer is a disease that is still a global problem which ranked second leading cause of death, amounting to 13% after cardiovascular disease. Cancer of the ovaries are the second most common group of gynecologic cancers, and account for about 5% of all women's cancers. Chemotherapy (chemo) is the use of drugs to treat cancer. Chemo can be useful to kill very small amounts of cancer cells that may still be around after surgery, for cancers that have metastasized (spread), or to shrink very large tumors to make surgery easier. Chemo drugs can cause side effects. These side effects usually go away after treatment is finished. Therapeutic herbs and their derivative phytocompounds are being progressively more accepted as useful complementary treatments for cancer. Zodia (Evodia sp) is Indonesian endemic plants containing some active compounds as anticancer there are evodiamine and evodone. In this study, we investigated the effectiveness of evodiamine and evodone by in silico method to threat ovarian cancer. This study uses Autodock, PyRx and LigPlot software with the method used is molecular docking. The docking results showed the effectiveness of the two compounds was assessed from binding affinity on evodiamine of -7 kcal / mol and RMSD (Root Mean Square Deviation) of 1.66 Å, while the evodone compound was -5.8 kcal / mol and 2.52 Å. From these results it can be proven that the evodiamine compound has the most effective results as an ovarian anticancer compound in silico.
- Copyright
- © 2019, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Erlix Rakhmad Purnama AU - Ghea Dionita Sanora AU - Elly Yana Mastura AU - Muhammad Ongky Muji Handoyo PY - 2019/12 DA - 2019/12 TI - Effectiveness of Evodiamine and Evodone as Ovarian Anticancer In Silico BT - Proceedings of the National Seminar on Chemistry 2019 (SNK-19) PB - Atlantis Press SP - 79 EP - 81 SN - 2590-3195 UR - https://doi.org/10.2991/snk-19.2019.4 DO - 10.2991/snk-19.2019.4 ID - Purnama2019/12 ER -