Absolute Eosinophil Count as a Marker for Sepsis Diagnosis
- 10.2991/ahsr.k.211130.019How to use a DOI?
- Eosinopenia; Absolute eosinophil count; Sepsis; Marker; Diagnosis
Eosinopenia, defined as low number of absolute eosinophil count, was used to support the diagnosis of sepsis in several studies by differentiating infection from non-infection cases. However, the results between studies were not consistent. This study was used to determine whether the eosinopenia served to distinguish sepsis from non-sepsis. A prospective cohort study was conducted on adult patients in the Intensive Care Unit (ICU) of Royal Taruma Hospital, Jakarta. Subjects were included in the sepsis group if they met the sepsis criteria (Surviving Sepsis Campaign). Within the study period from May 2016 to November 2016, there were 35 subjects recruited. From those, 17 subjects were diagnosed with sepsis. From statistical analysis with cut-off point of absolute eosinophil count <50 cells/uL, no significant difference was found in the proportion of subjects with eosinopenia between sepsis and non-sepsis. After the cut off point was changed into ≤90 cells/uL, we found significant difference of proportion of subjects with eosinopenia between sepsis and non-sepsis, with 70.6% sensitivity, 66.7% specificity, and area under the ROC curve (AUC) 0.314 (95%CI 0.134 to 0.494). In conclusion, the present study found an association between eosinopenia with the diagnosis of sepsis. However, considering the low sensitivity and specificity, our study did not recommend the use of absolute eosinophil count as single diagnostic tool.
- © 2021 The Authors. Published by Atlantis Press International B.V.
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Cite this article
TY - CONF AU - Frans JV Pangalila AU - Velma Herwanto AU - Riana AU - Enty Tjoa AU - Melina Hertanto AU - Yesyka Agustina AU - Suryanti Haryanto AU - Benjamin MP Tang PY - 2021 DA - 2021/12/01 TI - Absolute Eosinophil Count as a Marker for Sepsis Diagnosis BT - Proceedings of the 1st Tarumanagara International Conference on Medicine and Health (TICMIH 2021) PB - Atlantis Press SP - 98 EP - 102 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.211130.019 DO - 10.2991/ahsr.k.211130.019 ID - Pangalila2021 ER -