Absolute Eosinophil Count as a Marker for Sepsis Diagnosis

Frans JV Pangalila; Velma Herwanto; Riana; Enty Tjoa; Melina Hertanto; Yesyka Agustina; Suryanti Haryanto; Benjamin MP Tang

doi:10.2991/ahsr.k.211130.019

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Absolute Eosinophil Count as a Marker for Sepsis Diagnosis

Authors

Frans JV Pangalila¹^{, 2}^{, *}, Velma Herwanto¹^{, 2}, Riana², Enty Tjoa²^{, 3}, Melina Hertanto², Yesyka Agustina², Suryanti Haryanto², Benjamin MP Tang⁴

¹Universitas Tarumanagara, Faculty of Medicine, Jakarta, Indonesia

²Royal Taruma Hospital, Jakarta, Indonesia

³Universitas Atmajaya, Faculty of Medicine, Jakarta, Indonesia

⁴Department of Intensive Care Medicine, Nepean Clinical School, the University of Sydney, NSW, Australia

^*Corresponding author. Email: velmah@fk.untar.ac.id

Corresponding Author

Frans JV Pangalila

Available Online 1 December 2021.

DOI: 10.2991/ahsr.k.211130.019 How to use a DOI?
Keywords: Eosinopenia; Absolute eosinophil count; Sepsis; Marker; Diagnosis
Abstract: Eosinopenia, defined as low number of absolute eosinophil count, was used to support the diagnosis of sepsis in several studies by differentiating infection from non-infection cases. However, the results between studies were not consistent. This study was used to determine whether the eosinopenia served to distinguish sepsis from non-sepsis. A prospective cohort study was conducted on adult patients in the Intensive Care Unit (ICU) of Royal Taruma Hospital, Jakarta. Subjects were included in the sepsis group if they met the sepsis criteria (Surviving Sepsis Campaign). Within the study period from May 2016 to November 2016, there were 35 subjects recruited. From those, 17 subjects were diagnosed with sepsis. From statistical analysis with cut-off point of absolute eosinophil count <50 cells/uL, no significant difference was found in the proportion of subjects with eosinopenia between sepsis and non-sepsis. After the cut off point was changed into ≤90 cells/uL, we found significant difference of proportion of subjects with eosinopenia between sepsis and non-sepsis, with 70.6% sensitivity, 66.7% specificity, and area under the ROC curve (AUC) 0.314 (95%CI 0.134 to 0.494). In conclusion, the present study found an association between eosinopenia with the diagnosis of sepsis. However, considering the low sensitivity and specificity, our study did not recommend the use of absolute eosinophil count as single diagnostic tool.
Open Access: This is an open access article under the CC BY-NC license.

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Volume Title: Proceedings of the 1st Tarumanagara International Conference on Medicine and Health (TICMIH 2021)
Series: Advances in Health Sciences Research
Publication Date: 1 December 2021
ISBN: 10.2991/ahsr.k.211130.019
ISSN: 2468-5739
DOI: 10.2991/ahsr.k.211130.019 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC license.

Cite this article

ris enw bib

TY  - CONF
AU  - Frans JV Pangalila
AU  - Velma Herwanto
AU  - Riana
AU  - Enty Tjoa
AU  - Melina Hertanto
AU  - Yesyka Agustina
AU  - Suryanti Haryanto
AU  - Benjamin MP Tang
PY  - 2021
DA  - 2021/12/01
TI  - Absolute Eosinophil Count as a Marker for Sepsis Diagnosis
BT  - Proceedings of the 1st Tarumanagara International Conference on Medicine and Health (TICMIH 2021)
PB  - Atlantis Press
SP  - 98
EP  - 102
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.211130.019
DO  - 10.2991/ahsr.k.211130.019
ID  - Pangalila2021
ER  -

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