Proceedings of the Tapanuli International Health Conference 2022 (TIHC 2022)

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Toxicity Test of Karamunitng Leaf (Rhodomyrtus tomentosa (Aiton) Hassk.) Ekstratc with Finder Liquid Variation Using the Brine Shrimp Lethality Test (BSLT) Method

Authors
Marwati Marwati1, *, Yusnita Rifai2, Gemini Alam2, Risfah Yulianty2, Nur Samsiar1
1Department of Pharmaceutical, Sekolah Tinggi Ilmu Farmasi Makassar, Makassar, Indonesia
2Department of Pharmaceutical, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia
*Corresponding author. Email: watimar514@gmail.com
Corresponding Author
Marwati Marwati
Available Online 22 December 2022.
DOI
10.2991/978-94-6463-032-9_16How to use a DOI?
Keywords
Rhodomyrtus Tomentosa; Extract; Toxicity; BSLT; Anti cancer
Abstract

Karamunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) is a plant that is widely found in areas in Indonesia which has potential as an antioxidant so that it is the basis for the purpose of this study to see the toxicity effect of karamunting leaf extract. Extraction was carried out by maceration method using 3 types of solvents with different levels of polarity, namely ethanol (polar), ethyl acetate (semipolar) and n-hexane (nonpolar) against shrimp larvae (Artemia salina L.) using the BSLT method. Toxicity test using the BSLT method with Artemia salina L. bioindicator. The results obtained were analyzed by analysis to determine the value of Lethal Concerationt 50 (LC50). 10; 15; 20; and 25 µg / mL. Based on the results of observations and data analysis, it was found that the ethanol extract of karamunting leaves had a moderate toxic effect with the highest LC50 value, namely 70% ethanol extract of 11.55 µg / mL, ethyl acetate extract of 12.44 µg / mL and n-hexane extract. Karamounting to 15.77 µg / mL. Based on the results of this study indicate that the three extracts are included in the strong toxicity category with a range of 0–100 ppm.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the Tapanuli International Health Conference 2022 (TIHC 2022)
Series
Advances in Health Sciences Research
Publication Date
22 December 2022
ISBN
10.2991/978-94-6463-032-9_16
ISSN
2468-5739
DOI
10.2991/978-94-6463-032-9_16How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Marwati Marwati
AU  - Yusnita Rifai
AU  - Gemini Alam
AU  - Risfah Yulianty
AU  - Nur Samsiar
PY  - 2022
DA  - 2022/12/22
TI  - Toxicity Test of Karamunitng Leaf (Rhodomyrtus tomentosa (Aiton) Hassk.) Ekstratc with Finder Liquid Variation Using the Brine Shrimp Lethality Test (BSLT) Method
BT  - Proceedings of the Tapanuli International Health Conference 2022 (TIHC 2022)
PB  - Atlantis Press
SP  - 103
EP  - 109
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-032-9_16
DO  - 10.2991/978-94-6463-032-9_16
ID  - Marwati2022
ER  -