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4-(Thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives is an important intermediate which inhibited tumor necrosis factor alpha and nitric oxide. In this work, a rapid and green synthetic method for compound (5) was established. The compound (5) was synthesized from the commercially available methyl 3-aminothiophene-2-carboxylate...

Afatinib (1) exhibited potential biological activities in medicine. There are shortcomings in the synthesis route of afatinib in the literature, the product yield is low and the post-processing is complicated. Therefore, in this paper, the two-step synthetic route of afatinib was optimized. The two-step...

3-phenyl-1H-pyrazole (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from acetophenone (2) and hydrazine through two steps including Knoevenagel condensation, Cyclization reaction reaction. In this paper, three novel 3-phenyl-1H-pyrazole derivatives...

To improve the teaching quality of "aquatic microbiology" course.The teaching reform exploration of aquatic microbiology was carried out in recent 5 years and summarized, which including grasping the course nature of "aquatic microbiology" by means of aquaculture professional training program, revising...

The research on cost stickiness behavior is mainly about sales & administrative cost and manufacturing industry, lacking studies on particular niche business. Therefore, the real estate industry paid highly attention was chosen as the research object and an empirical analysis of cost stickiness behavior...

Web service is very important for both e-commerce and e-government. However, web service process based on syntax level can’t deal with some user query very effectively. In order to make user get more information on the internet, semantic web is presented and a lot of related research results have been...

Fuzzy distance is applied on data analysis, classification, and production positioning analysis widely. In this paper, We introduction a fuzzy distance by using graded mean integration representation of generalized fuzzy number and the span of fuzzy number, We also discuss the distance of the linguistic...

A general phenomenon puzzles all investors is that on one hand, most individual investors believe they need to construct the portfolio consisting of 15 or more stocks to prevent risk because that large investment companies frequently get high returns is due to they obey the existing investment theory...

We have experimentally demonstrated the gain-clamped wideband optical amplifier using a DCF-based Raman amplifier and an semiconductor optical amplifier for 90-nm wide bandwidth amplification with good gain flatness (of 3 dB) as well as dispersion compensation of 10Gb/s DWDM signals over 100-km SMF link....