Artery Research

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Volume 22, Issue C, June 2018, Pages 36 - 42

A comparative study of vasa vasorum density among coronary arteries

Authors
Keerthana Panchagnulaa, Rohini Punjab, Dhiren Punjac, *, Chinmay Suryavanshic
aKasturba Medical College, Manipal, 576104, India
bDepartment of Anatomy, Kasturba Medical College, Manipal, 576104, India
cDepartment of Physiology, Kasturba Medical College, Manipal, 576104, India
*Corresponding author. E-mail address: dhiren.punja@manipal.edu (D. Punja).
Corresponding Author
Dhiren Punja
Received 10 February 2018, Revised 28 March 2018, Accepted 18 April 2018, Available Online 4 May 2018.
DOI
10.1016/j.artres.2018.04.002How to use a DOI?
Keywords
Adventitial vasa vasorum; Atherosclerosis predisposition; Histological staining technique
Abstract

Background: Coronary arteries exhibit significantly higher adventitial Vasa vasorum (VV) densities which may partly explain their higher atherosclerosis susceptibility. A variability in the atherosclerosis predispositions exists between individual coronary artery branches but few studies exist that compare their VV densities. This study aims to assess for VV density differences between individual coronary artery branches and also compare them with other similar sized peripheral arteries.

Methods: Cadaveric arterial specimens, 15 each, from right coronary [RCA], left anterior descending [LAD], left circumflex [LCX] radial [RA] and fibular arteries [FA] were collected, processed and stained. Images were taken using digital Motic camera enabled microscope and Motic Image plus 2.0 ML software. VV were visually identified and counted. Open source software Image J was used to measure the adventitial surface area. VV number per unit area was expressed as density.

Results: Mean adventitial VV density (*10−5/μm2) was significantly higher in the RCA (2.14 SD 0.92) compared to the LAD (1.2 SD 0.72) RA (1.23 SD 0.41) and FA (0.77 SD 0.84). VV density in LAD was comparable to LCX (1.88 SD 0.83), RA and FA

Conclusion: LAD showed the least VV density among coronary arteries, even though most studies show this artery to have the highest atherosclerosis incidence. Interactions between high and low VV density areas within an artery rather than net VV density may be a more significant determining factor for atherosclerosis predisposition. Structural and molecular characteristics of the vessel wall, as well as that of VV, may also be contributing factors.

Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
22 - C
Pages
36 - 42
Publication Date
2018/05/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.04.002How to use a DOI?
Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Keerthana Panchagnula
AU  - Rohini Punja
AU  - Dhiren Punja
AU  - Chinmay Suryavanshi
PY  - 2018
DA  - 2018/05/04
TI  - A comparative study of vasa vasorum density among coronary arteries
JO  - Artery Research
SP  - 36
EP  - 42
VL  - 22
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.04.002
DO  - 10.1016/j.artres.2018.04.002
ID  - Panchagnula2018
ER  -