Artery Research

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2992 articles
Research Article

Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol

Rosa Maria Bruno, Bart Spronck, Bernhard Hametner, Alun Hughes, Patrick Lacolley, Christopher C. Mayer, Maria Lorenza Muiesan, Chakravarthi Rajkumar, Dimitrios Terentes-Printzios, Thomas Weber, Tine Willum Hansen, Pierre Boutouyrie,
In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences...
Research Article

Factors Associated with Cardio Ankle Vascular Index (CAVI) and its Mathematically Corrected Formula (CAVI0) in Community Dwelling Individuals

Li-Ju Lin, Nan-Chen Hsieh, Shu-Fang Vivienne Wu, Tan-Hsu Tan, Azadeh Alizargar, Chyi-Huey Bai, Javad Alizargar
Cardio Ankle Vascular Index (CAVI) and mathematically corrected formula derived from it (CAVI0) are indices for arterial stiffness and atherosclerosis. Role of different atherosclerotic risk factors on CAVI and CAVI0 is not clear in the community dwelling individuals. This study aims to evaluate the...
Research Article

Radial Pulse Wave Analysis in Young Male Elite Athletes

Fernando Clara, José Alfie, Gustavo Blanco, Cecilia Resina, Meschino Gustavo, Mariana Fita
Background: Indicators obtained from the analysis of the radial pulse wave allow an indirect evaluation of the interaction between cardiac ejection and arterial walls. Objectives: To analyze the characteristics of the arterial pulse in young elite athletes through a cross-sectional observational study. Methods:...
Research Article

Central Blood Pressure in Young Kendo Athletes: Implications of Combined Anaerobic and Strength Training

Masaki Yoshioka, Kaname Tagawa, Yuriko Tochigi, Tomohito Sato, Jiyeon Park, Reiko Momma, Youngju Choi, Jun Sugawara, Seiji Maeda
Background: Exercise training-induced adaptation of central Blood Pressure (BP) depends on exercise mode. Kendo, a traditional Japanese martial art, is a unique exercise mode because its training encompasses anaerobic and resistance training components. However, the effects of habitual kendo training...
Research Article

Differential Sensitivity of Brachial-Ankle Pulse Wave Velocity and Ankle-Brachial Index for Cardiovascular Risk Assessment in Elderly Chinese: A Cross-Sectional Study

Guoxiang Fu, Yuan Zhong, Fengfeng Pan, Chanchan Xu
Background: Brachial-Ankle Pulse Wave Velocity (baPWV) and Ankle-Brachial Index (ABI) are widely used in clinic for evaluating arterial stiffness and atherosclerosis separately. This study aimed to compare the sensitivity of baPWV and ABI for cardiovascular risk assessment in elderly Chinese. Methods:...
Research Article

Homebased Standing Core Exercise Training Improves Femoral Blood Flow but not Arterial Stiffness in Middle-Aged to Older Adults

Hsin-Fu Lin, Soun-Cheng Wang, Hao-Min Cheng, Jun Sugawara
Homebased exercise is often advocated to improve physical fitness in the aging population, especially when outdoor activity is not available. Yet we often have a limited understanding of its training effects for clinical uses. Aim: To investigate a short-term exercise training of standing core exercise...
Research Article

KCa3.1 Inhibition Decreases Size and Alters Composition of Atherosclerotic Lesions Induced by Low, Oscillatory Flow

Darla L. Tharp, Douglas K. Bowles
Low, oscillatory flow/shear patterns are associated with atherosclerotic lesion development. Increased expression of KCa3.1 has been found in Vascular Smooth Muscle (VSM), macrophages and T-cells in lesions from humans and mice. Increased expression of KCa3.1, is also required for VSM cell proliferation...
Research Article

Therapeutic Effects of Interventional Therapy and Conservative Therapy on Lower Extremity Arteriosclerosis Obliterans and Risk Factors for Prognosis

Lingxiong Chen, Xuming Zhang, Fuyan Jiang, Zhida Yin, Jinqiu Xue, Chengmei Ruan, Lijiao Xie
Background: Arteriosclerosis Obliterans (ASO) is an important cause for lower limb amputation. We aimed to compare the effects of interventional and conservative therapies on lower extremity ASO, and to analyze the risk factors for prognosis. Methods: Ninety-eight eligible patients were randomly divided...
Research Article

Birth Weight in Relation to Post-Natal Growth Patterns as Predictor of Arterial Stiffness and Central Hemodynamics in Young Adults from a Population-based Study

Johannes Sperling, Shantanu Sharma, Peter M. Nilsson
Objective: Our aim was to examine the impact of mismatch patterns reflecting pre- and post-natal growth conditions on markers of arterial stiffness and central hemodynamics in young adults. Methods: In all, 1056 participants from Malmö Offspring Study, 484 men and 572 women (age-range 18–44 years),...
Research Article

Reliability of Finger Photoplethysmogram Assessment: Effect of Mental Stress and Day-to-Day Variability

Marina Fukuie, Takashi Tarumi, Takayuki Yamabe, Jun Sugawara
Frequent assessment of vascular health (e.g., arterial stiffness) may predict the incidence of cardiovascular disease. The Second Derivative of the finger Photoplethysmogram Aging Index (SDPTGAI) may be used as an index of vascular aging and a screening tool for arteriosclerotic disease. To test its...
Conference Abstract

WHAT IS THE BEST METHOD TO EVALUATE RETINAL MICROCIRCULATION?

Joanna Harazny
Pages: 1 - 2
The microvasculature of retinal ganglion cell layer, which is the part of central nervous system, can be investigated non-invasively in human. For clinical routine the fluorescence angiography is used to test patency and leak of retinal or choroid vessels, and to determine the blood passage time through...
Research Article

Editorial

John R. Cockcroft,
Pages: 1 - 2
Conference Abstract

CD1 VASCULAR ADAPTATION TO EXTREME CONDITIONS: THE ROLE OF HYPOXIA

Rosa Maria Bruno*, Lorenzo Ghiadoni, Lorenza Pratali
Pages: 1 - 1
The study of vascular adaptation to extreme conditions, and in particular to hypoxia, represents a unique opportunity in cardiovascular physiology, with relevant translational implications. First, it has crucial clinical consequences for about 140 million people worldwide living at high altitude and...
Short Communication

Pharmacological Management of Hypertension Guided by Central or Peripheral Blood Pressure Measurement: Comparison of Two Strategies on the Incidence of Intermediate Outcome

Weimar Kunz Sebba Barroso, Sayuri Inuzuka, Gilberto Campos Guimarães, Robson Pierre Pacífico, Victoria Alves Melo, Luiz Fernando Oliveira, Eduarda Silva, Gustavo Ribeiro Mesquita, Deborah Silva Cintra Valle, Priscila Valverde Vitorino, Ana Luiza Lima Sousa, Paulo César Brandão Veiga Jardim, Antonio Coca
Pages: 1 - 4
Background: Central blood pressure values and arterial stiffness have demonstrated to be a useful tool to stratify cardiovascular risk and also as a biomarker. A question that is still unanswered is if hypertension treatment guided by central blood pressure parameters will be even better to promote cardiovascular...
Research Article

A numerical study on the application of the functionally graded bioabsorbable materials in the stent design

Hossein Bahreinizad, Milad Salimi Bani, Arezoo Khosravi, Alireza Karimi
Pages: 1 - 8
Background: Angioplasty with stenting is one of the primary treatment for coronary artery disease, hence, performance of the stent is deemed important. Bioabsorbable stents are the new generation of stents. Bioabsorbable magnesium alloys are a promising solution for adverse effects of long-term usage...
Research Article

Does combining elastic and weight resistance acutely protect against the impairment of flow-mediated dilatation in untrained men?

Kampanart Paditsaeree, Witid Mitranun
Pages: 1 - 8
Background: The evidence that the combination of elastic and weight resistance training acutely affects or improves resultant responses to conduit artery function is anecdotal. The aim of this study was to examine brachial artery flow-mediated vasodilation (FMD) before and after acute exercise when performed...
Research Article

Brachial flow-mediated dilatation response to acute different upper body training postures in lean inactive vs. lean active men

Witid Mitranun, Prasit Peepathum
Pages: 1 - 7
Background: Resistance training postures trigger different results on endothelial function: however, the acute effect of resistance training on upper body muscle in active and inactive persons is inconclusive. The present study aimed to investigate the acute effects of 2 different types of upper body...
Research Article

Effect of angulation and Reynolds number on recirculation at the abdominal aorta-renal artery junction

Mohammed Ameenuddin, Mohan Anand
Pages: 1 - 8
We investigate the effect of renal artery angle variation and Reynolds number on the probability of formation of atherosclerosis-prone regions at the abdominal aorta-renal artery junction. The rheologically accurate shear-thinning Yeleswarapu model for blood is used to simulate flow in a 3-Dimensional...
Research Article

LDL fatty acids composition as a risk biomarker of cardiovascular disease

Hashem Nayeri, Gholam Ali Naderi, Sedigheh Asgari, Masoumeh Sadeghi, Maryam Boshtam, Samaneh Mohamadzadeh, Nasim Babaknejad
Pages: 1 - 7
Objective: Fatty acid composition of Low-density lipoprotein (LDL) particle is an effective factor in LDL oxidation and atherosclerotic plaques formation. This study evaluates the relationship between LDL fatty acid composition and coronary artery disease (CAD). Methods: 42 men with coronary artery...
Research Article

Change of bilateral difference in radial artery pulse morphology with one-side arm movement

Xinge Jiang, Shoushui Wei, Dingchang Zheng, Feifei Liu, Shouqin Zhang, Zhimin Zhang, Chengyu Liu
Pages: 1 - 8
Previous studies have demonstrated that the compliance of peripheral artery changes with arm movement. This study aimed to quantify the bilateral difference in radial artery pulse morphology with one-side arm movement. Twenty-four healthy subjects were recruited. Radial artery pulses were synchronously...
Research Article

Retinal vascular calibers in contemporary patients with chronic systemic inflammatory diseases: The Greek REtinal Microcirculation (GREM) study

Evaggelia K. Aissopou, Athanase D. Protogerou, Theodore G. Papaioannou, Maria Tektonidou, Nikolaos Tentolouris, Panagiotis G. Theodossiadis, Coen D.A. Stehouwer, George D. Kitas, Petros P. Sfikakis
Pages: 1 - 6
Background: Chronic systemic inflammatory diseases (CSID) are associated with increased cardiovascular morbidity and mortality. Widening of retinal venular calibers has been independently associated with systemic inflammation and cardiovascular risk in the general population. We aimed to test the hypothesis...
Review Article

Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value

Bryan Williams, Patrick Brunel, Peter S. Lacy, Fabio Baschiera, Dion H. Zappe, Kazuomi Kario, John Cockcroft
Pages: 1 - 15
Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular (CV) events. However, recent clinical evidence suggests that central aortic pressure (CAP) provides additional information for assessing CV risk than brachial blood...
Research Article

Experimental verification of the healthy and atherosclerotic coronary arteries incompressibility via Digital Image Correlation

Alireza Karimi, Toshihiro Sera, Susumu Kudo, Mahdi Navidbakhsh
Pages: 1 - 7
So far there is no study to measure the Poisson’s ratio of the human coronary arteries in order to verify their incompressibility regardless of being healthy or atherosclerosis. It has been reported that atherosclerosis alters the elastin content of the arterial wall which is responsible for the elastic...
Research Article

The effects of pipe water smoking on endothelial function in healthy non smoker volunteers

Rania Gaber, Manal Hamesa
Pages: 1 - 5
Background: Water pipe (WP) tobacco smoking is gaining wide popularity among young and middle aged males and females. Aim of the work: The aim of this study was to evaluate the immediate effect of 1st pipe water smoking on brachial Flow mediated dilatation% (FMD%) and Nitrate mediated dilatation% (NMD%)...
Review Article

The effects of antihypertensive drugs on arterial stiffness

Lorenzo Ghiadoni
Pages: 1 - 5
Ageing and cardiovascular risk factors, particularly uncontrolled hypertension, adversely impact arterial stiffness and wave reflection leading to increased central systolic blood pressure. Carotid-femoral pulse wave velocity is the “gold standard” method for the assessment of aortic stiffness. Increased...
Short Communication

A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies

Riaz Akhtar, J. Kennedy Cruickshank, Xuegen Zhao, Brian Derby, Thomas Weber
Pages: 1 - 5
This study explores the use of scanning acoustic microscopy (SAM) as a potential tool for characterisation of arterial stiffness using aortic biopsies. SAM data is presented for human tissue collected during aortic bypass graft surgery for multi-vessel coronary artery disease. Acoustic wave speed as...
Research Article

Complex vasoactivity of liraglutide. Contribution of three gasotransmitters

Eszter Sélley, Gergő A. Molnár, Szilárd Kun, István András Szijártó, Boglárka Laczy, Tibor Kovács, Ferenc Fülöp, István Wittmann
Pages: 1 - 9
Background: Incretine hormone glucagon-like peptide-1 (GLP-1) causes dose-dependent relaxation of the thoracic aorta of rats and other arteries via nitric oxide (NO), cAMP and ATP-sensitive potassium channels, however, through a mechanism not thoroughly described. Hereby we aimed to determine the mediators...
Review Article

Optimality, cost minimization and the design of arterial networks

Alun D. Hughes
Pages: 1 - 10
The arterial circulation acts as a network to deliver nutrients and oxygen to cells. The design of the cardiovascular system is subject to a variety of constraints and costs. It has been postulated that the design of the arterial network might be understood in terms of the need to minimize competing...
Review Article

Central pressure should be used in clinical practice

James E. Sharman
Pages: 1 - 7
The original purpose for recording brachial blood pressure (BP) more than 100 years ago was to estimate central (aortic) BP. While high brachial BP is an important cardiovascular risk factor, it is clear that major differences in central systolic BP (SBP; e.g. >30 mmHg) can occur among people with similar...
Mini Review

In vitro characterisation of arterial stiffening: From the macro- to the nano-scale

Riaz Akhtar
Pages: 1 - 8
Accurate measurement of the material properties of arterial tissue is important for better characterisation of diseases and the development of reliable computational models. There are a number of in vitro techniques that are applied to study the biomechanical properties of arterial tissue. This review...
Conference Abstract

P4.02 Assessing ventricular–vascular interactions non-invasively in healthy adolescents☆

T.J. Bradley, C. Slorach, C. Manlhiot, W. Hui, M.K. Friedberg, E.T. Jaeggi, P.F. Kantor, L. Mertens
Pages: 1 - 1
Background: Characterization of normal ventricular–vascular interactions by non-invasive assessment in healthy adolescents may provide new mechanistic insights into altered physiological states in congenital and acquired heart disease in this age group. Methods: Ventricular and vascular measures were...
Mini Review

Wave transmission and reflection of waves “The myth is in their use”

Nico Westerhof, Berend E. Westerhof
Pages: 1 - 6
Arterial input impedance, as complete description of the arterial system, is explained by waves and wave reflection. Without wave reflections input impedance would equal aortic characteristic impedance and pressure and flow wave shapes would be similar. Waves reflect at many locations, causing input...
Review Article

The life and times of Donald A. McDonald

Wilmer W. Nichols, Michael F. O’Rourke
Pages: 1 - 8
Donald A. McDonald (1917–1973) was a pioneer in hemodynamics. He was Oxford educated and served on the faculty of Universities in both Great Britain and the USA. The problems that were the main theme of his text Blood Flow in Arteries published in 1960 were those concerned with pulsatile blood flow and...
Research Article

Isolated systolic hypertension and the J-curve of cardiovascular disease risk

Stanley S. Franklin
Pages: 1 - 6
Controversy persists regarding the presence and significance of blood pressure “J-curves” of increased cardiovascular disease (CVD) risk as they relate to older people with isolated systolic hypertension (ISH). Age is an important effect modifier favoring diastolic blood pressure (DBP) in young adults,...
Research Article

Factors influencing hemodynamic and morphological indicators of carotid arteries atherosclerosis in treated hypertensive patients

Anna Skalska, Ewa Klimek, Tomasz Grodzicki
Pages: 1 - 7
Objectives: To evaluate factors influencing resistive index (RI) and intima-media thickness of common carotid artery (IMT-CCA) as indices of arterial atherosclerosis in hypertensive patients. Methods: 56 treated hypertensive outpatients (mean age 68.9 ± 9.7 years; 31 diabetics) were examined. Fasting...
Review Article

Does Treatment for Obstructive Sleep Apnoea Improve Arterial Stiffness? Evidence from Randomized Clinical Trials on Carotid-femoral Pulse Wave Velocity

D. Marcon, L. Faconti, B. Farukh, R. McNally, C. Fava, M. Pengo, P. Chowienczyk, J.K. Cruickshank
Pages: 1 - 6
Obstructive Sleep Apnoea (OSA) is a breathing disorder characterized by narrowing of the upper airway that impairs normal ventilation during sleep. OSA is a highly prevalent condition which is associated with several Cardiovascular (CV) risk factors and CV diseases. Despite this clear association, Randomized...
Conference Abstract

CD2 CIRCADIAN BLOOD PRESSURE PROFILE AND TARGET ORGAN DAMAGE

Agnieszka Bednarek
Pages: 1 - 1
The 24-hour brachial ambulatory blood pressure measurement (ABPM) has the unique ability to provide information on 24-hour averaged blood pressure (BP), on nocturnal BP and day–night BP changes, as well as on 24-hour BP variability, which all provide independent prognostic information over that provided...
Conference Abstract

CD3 ALDOSTERONISM, HEART AND VESSELS

Aleksander Prejbisz
Pages: 1 - 1
It has been documented that absolute aldosterone excess in patients with primary aldosteronism (PA) has been associated with higher risk of heart, vascular and kidney damage independent on blood pressure and resulting in increased total cardiovascular risk. Structural (left ventricular hypertrophy) and...
Conference Abstract

RETINAL ARTERIOLAR STRUCTURE IN PRIMARY HYPERTENSION – REVIEW OF THE DATA

Andrzej Januszewicz
Pages: 2 - 2
Vascular dysfunction and remodelling due to elevated blood pressure constitutes an early step in the pathogenesis of atherosclerotic disease. Microvascular remodelling reduces tissue perfusion and impedes blood-tissue exchange. These processes could lead to inadequate perfusion and tissue hypoxia in...
Conference Abstract

SODIUM INTAKE IN RELATION TO CARDIOVASCULAR OUTCOME

Katarzyna Stolarz-Skrzypek
Pages: 2 - 2
The data associating blood pressure to salt intake in humans comes from randomized clinical trials of interventions on dietary salt intake and population studies. Generally, estimates from meta-analyses are similar to those derived from prospective population studies (1.7 mm Hg change in systolic blood...
Mini Review

Ventricular–arterial coupling: Invasive and non-invasive assessment

Julio A. Chirinos
Pages: 2 - 14
Interactions between the left ventricle (LV) and the arterial system, (ventricular–arterial coupling) are key determinants of cardiovascular function. Ventricular–arterial coupling is most frequently assessed in the pressure–volume plane using the ratio of effective arterial elastance (EA) to LV end-systolic...
Research Article

Abridged version of the expert consensus document on arterial stiffness

Stephane Laurent, John Cockcroft, Luc Van Bortel, Pierre Boutouyrie, Cristina Giannattasio, Daniel Hayoz, Bruno Pannier, Charalambos Vlachopoulos, Ian Wilkinson, Harry Struijker-Boudier,
Pages: 2 - 12
In recent years great emphasis has been placed on the role of arterial stiffness in the development of cardiovascular diseases. The present article is an abridged version of an expert consensus document reporting the proceedings of several meetings of the European Network for Non Invasive Investigation...
Conference Abstract

P1.1 PHYSICAL ACTIVITY IS ASSOCIATED WITH FLOW-MEDIATED DILATATION IN FEMALES

Ulrika Ferberg*, Katya Matusevich, Gabriella Eliason, Maria Fernstom, Anita Hurtig-Wennlof
Pages: 3 - 3
Impairment of vascular endothelial function is an early sign of atherosclerosis. An active lifestyle is suggested to be positively associated with favorable endothelial function as opposed to a sedentary lifestyle. The aim of this ongoing study (Lifestyle, Biomarkers and Atherosclerosis Study) is to...
Conference Abstract

P1.2 NANOMECHANICAL ALTERATIONS IN THE ADVENTITIAL LAYER OF THE INTERNAL MAMMARY ARTERY OF PATIENTS WITH HIGH PWV

Zhuo Chang, Maria Lyck Hansen, Lars Melholt Rasmussen, Riaz Akhtar*
Pages: 3 - 3
Aim: Arterial stiffening occurs as part of the natural ageing process, and is thought to be related to the accumulation of collagen and degradation of elastin. However, little is known about how regional variations in arterial structure and mechanical properties contribute to arterial stiffening. This...
Review Article

Quality of Reporting in Human Aortic Tissue Research – A Systematic Review

Ya-Hua Chim, Eva Caamaño-Gutiérrez, Rashmi Birla, Jillian Madine, Mark Field, Riaz Akhtar, Hannah Angharad Davies
Pages: 3 - 10
Ex vivo human tissue is a valuable research resource. However, if vital methodological information such as anatomical location, tissue processing procedures, or donor characteristics are not reported in scientific literature to a high standard, studies utilising ex vivo human tissue can be difficult...
Conference Abstract

P1.3 A NEW DYNAMIC ORGAN BATH SETUP TO ASSESS ISOBARIC STIFFNESS PARAMETERS OF PERIODICALLY STRETCHED ISOLATED MOUSE AORTIC SEGMENTS

Arthur J.A. Leloup*, Cor E. Van Hove, Guido R.Y. De Meyer, Dorien M. Schrijvers, Gilles W. De Keulenaer, Paul Fransen
Pages: 3 - 4
Cyclic stretch is a major contributor of vascular function. However, isolated mouse aortas are frequently studied at low stretch frequency or even isometric conditions. Pacing experiments done in rodents and humans show that arterial compliance is highly cyclic stretch frequency-dependent. The Rodent...
Short Communication

Assessment of pulse wave velocity

Pierre Boutouyrie, Marie Briet, Cédric Collin, Sebastian Vermeersch, Bruno Pannier
Pages: 3 - 8
Measurement of pulse wave velocity is of increasing importance for assessment of arterial stiffness and risk evaluation. Different techniques are available, based either on pressure, distension or Doppler waveforms. Techniques not only differ by the algorithm used to identify specific part of the pulse...
Conference Abstract

P1.4 HEMODYNAMICS OF PULMONARY HYPERTENSION: APPLICATION OF THE RESERVOIR-WAVE APPROACH

Anukul Ghimire*, Mads Andersen, Lindsay Burrowes, J. Christopher Bouwmeester, Andrew Grant, Israel Belenkie, Nowell Fine, Barry Borlaug, John Tyberg
Pages: 4 - 4
Using the reservoir-wave approach, previously we characterized pulmonary vasculature mechanics with multiple interventions in a canine model. In the present study, we measured high-fidelity pulmonary arterial (PA) pressure, Doppler flow velocity, and pulmonary capillary wedge pressure in 11 patients...
Conference Abstract

P1.5 AGE AND HYPERTENSION STRONGLY REDUCE AORTIC VISCO-ELASTIC PROPERTIES IN RATS AT BASAL AND MATCHED BLOOD PRESSURE LEVELS

George Lindesay*, Christophe Ragonnet, Stefano Chimenti, Nicole Villeneuve, Christine Vayssettes-Courchay
Pages: 4 - 4
Age and hypertension are major causes of large artery stiffening, a cardiovascular risk factor for heart and kidney damage. Long term hypertension induces vascular remodeling, accelerating vascular aging. The aged Spontaneously Hypertensive Rat (SHR) model is recognized for human cardiovascular pathology...
Conference Abstract

P1.8 DEVELOPMENT OF A TECHNIQUE FOR DETERMINATION OF PULMONARY ARTERY PULSE WAVE VELOCITY IN HORSES

Gonçalo Silva*, Bruce Guest, Diego Gomez, Martine McGregor, John Runciman, Luis Arroyo
Pages: 4 - 4
Calcification of the tunica media of the main pulmonary arteries has been observed in a large proportion of young racehorses. In humans, medial calcification is the most important cause of increased arterial stiffness, and has been implicated in the pathogenesis of microvascular diseases. Pulse wave...
Conference Abstract

P1.9 PLATELET-LOCALIZED FXI PROMOTES A GLYCOPROTEIN IBα DEPENDENT FEEDBACK LOOP IN ARTERIAL HYPERTENSION AND VASCULAR INFLAMMATION

Jeremy Lagrange*, Sabine Kossmann, Moritz Ehlken, Brett Monia, Wolfram Ruf, Philip Wenzel
Pages: 4 - 5
Background: Interactions of platelets, leukocytes and the vessel wall play pivotal roles in activating coagulation and precipitating thrombosis. High levels of angiotensin II (ATII) cause arterial hypertension by a complex inflammatory pathway requiring leukocyte recruitment and reactive oxygen species...
Conference Abstract

P1.10 PULSE PRESSURE IN RELATION TO 24-HOUR URINARY SODIUM EXCRETION IN A SAMPLE OF HIGH-SALT INTAKE POPULATION

Adam Bednarski*, Katarzyna Stolarz-Skrzypek, Grzegorz Kielbasa, Agata Franczyk, Malgorzata Kloch-Badelek, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 5 - 5
Objectives: In recent years, many studies emphasized the role of arterial rigidity in the development of cardiovascular diseases. Pulse pressure in an easy-obtained, reproducible marker of arterial stiffness and an independent cardiovascular risk factor. On the other hand it was observed that sodium...
Conference Abstract

P1.11 SOLUBLE IL-6 RECEPTOR CONCENTRATIONS ARE ASSOCIATED WITH AUGMENTATION INDEX IN HEALTHY YOUNG MALES

Matthew Armstrong*, Cat Singh, Laura Watkeys, Linnet Thekkemuriyil, Jordan Tucker, Zoe Marshall, Richard Webb, Barry McDonnell
Pages: 5 - 5
Background: Augmentation Index (AIx) is considered a sensitive marker of arterial stiffness in young individuals. Increased levels of inflammatory markers such as interleukin-6 (IL-6) are associated with increased levels of arterial stiffness in older and diseased populations. However, little is known...
Conference Abstract

P1.12 IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION ARTERIAL NARROWING IS LIMITED AND HETEROGENEOUS

Nina Rol*, Esther Timmer, Theo Faes, Harm Jan Bogaard, Anton Vonk Noordegraaf, Katrien Grünberg, Nico Westerhof
Pages: 5 - 5
Rationale: In severe idiopathic pulmonary arterial hypertension, iPAH, pulmonary vascular resistance is increased due to remodeling of the small (resistance) arteries. Most information on arterial remodeling is limited to assessments of averaged increases in wall thickness. Quantitative information on...
Conference Abstract

P1.13 CHANGES IN PULSE WAVE VELOCITY ALONE CANNOT PREDICT THE PULSE PRESSURE INCREASE WITH AGE

Berend Westerhof*, Thomas Weber, Siegfried Wassertheurer, Bernhard Hametner, Nico Westerhof
Pages: 5 - 6
Recently Weber et al. invasively obtained aortic Pulse Wave Velocity (PWV) as a function of age. [1] Systolic and diastolic aortic pressure were determined as well. PWV can be used to derive total arterial compliance, Ctot, as Ctot=k/PWV2. With Ctot and Stroke Volume (SV), aortic Pulse Pressure (PP)...
Research Article

Reproducibility in Echotracking Assessment of Local Carotid Stiffness, Diameter and Thickness in a Population-based Study (The STANISLAS Cohort Study)

Erwan Bozec, Nicolas Girerd, João Pedro Ferreira, Ichraq Latar, Faiez Zannad, Patrick Rossignol
Pages: 5 - 12
Background: Carotid Intima Media Thickness (IMT) and stiffness are associated with cardiovascular events. The study aims were to perform a head-to-head comparison of the Wall Track System (WTS) and ART.LAB for carotid IMT, distension and diameter echotracking measurements as well as inter- and intra-observer...
Conference Abstract

P1.14 ANALYSIS OF LEFT VENTRICULAR FILLING DYNAMICS

Lindsay Burrowes*, Alessandro Satriano, Richard Thompson, Nigel Shrive, John Tyberg
Pages: 6 - 6
Diastolic filling of the left ventricle (LV) occurs in two phases, early and late filling. Early filling, manifest as the “E-wave”, is thought to be substantially due to diastolic suction (DS), a phenomenon where the LV aspirates blood and fills itself, independent of atrial activity. Late filling, resulting...
Conference Abstract

P1.15 CONDITIONAL INACTIVATION OF INTEGRIN AV SUBUNIT IN VASCULAR SMOOTH MUSCLE CELLS REGULATES FIBROSIS IN VESSELS

Ekaterina Belozertseva*, Melusine Didelot, Amel Mohamadi, Zhenlin Li, Huguette Louis, Jean-Baptiste Michel, Véronique Regnault, Patrick Lacolley
Pages: 6 - 6
Integrin avb3 is expressed at high density in vascular smooth muscle cells (VSMCs). It functions as a receptor for adhesion proteins in VSMCs which phenotypic modulation plays a pivotal role in arteriosclerosis and atherosclerosis. The aim was to study the role of integrin avb3 in angiotensin II (Ang...
Conference Abstract

P1.17 THE VENTRICLE’S PROMINENT ROLE IN PRESSURE AMPLIFICATION; AN INCREMENTAL EXPERIMENTAL STUDY

Nicholas Gaddum*, Jordi Alastruey, Tobias Schaeffter, Phil Chowienczyk
Pages: 6 - 6
Despite central pressure’s predictive power of cardiovascular risk, brachial pressure is the clinical standard. However, amplified brachial systolic pressure varies significantly with age, and during therapy. Our aim was to modulate individual arterial and ventricular parameters in an experimental model...
Conference Abstract

P2.1 AGING AND STRUCTURAL ALTERATIONS OF SUBCUTANEOUS SMALL RESISTANCE ARTERIES IN HYPERTENSIVE PATIENTS

Carolina De Ciuceis, Claudia Rossini, Claudia Agabiti Rosei, Enzo Porteri, Alice Gavazzi, Stefano Caletti, Paola Pileri, Maria Antonietta Coschignano, Enrico Agabiti Rosei, Damiano Rizzoni*
Pages: 6 - 6
Background: It was proposed that early vascular ageing may be an important mechanism of vascular damage in large conductance arteries. However it is not known whether aging may also affect small resistance artery morphology. Patients and methods: For this reason, we investigated 100 patients with essential...
Conference Abstract

P2.2 RESISTANT HYPERTENSION AND STRUCTURAL ALTERATIONS OF SUBCUTANEOUS SMALL RESISTANCE ARTERIES

Claudia Agabiti Rosei, Carolina De Ciuceis, Claudia Rossini, Maria Lorenza Muiesan, Massimo Salvetti, Enzo Porteri, Alice Gavazzi, Anna Paini, Stefano Caletti, Maria Antonietta Coschignano, Paola Pileri, Enrico Agabiti Rosei, Damiano Rizzoni*
Pages: 6 - 7
Background: It is was suggested that, in resistant hypertension, the presence of particularly pronounced microvascular alterations may contribute to explain the relative lack of response to treatment. Similarly, in diabetic patients, the persistence of an altered microvascular structure, despite the...
Research Article

The effect of ginseng supplement on heart rate, systolic and diastolic blood pressure to resistance training in trained males

Samira Zaheri, Seyed Mohammed Marandi
Pages: 6 - 11
Objectives: Ginseng Panax has been used for centuries in Chinese medicine as source of health and stamina. We want to examine the affect of ginseng supplement on heart rate, systolic; blood pressure and diastolic blood pressure in trained athletes at rest, during and after resistance; training. Methods:...
Short Communication

Repeatability measurements of second systolic shoulder of the radial waveform and peripheral augmentation index with the OMRON HEM-9000AI device in a sample of young Mexican subjects

Carlos G. Ramos, Guillermo A. Alanis, Fernando Grover, David Cardona, Mayra Jimenez, Victor Guzman, Patricia Quezada, Sara Pascoe, Leonel Garcia, Sylvia E. Totsuka, Ernesto G. Cardona
Pages: 6 - 9
The development of non-invasive technology to perform pulse wave analysis and accurately determine central blood pressure has facilitated the study of central blood pressure as a physiologic and biomarker parameter. Central systolic blood pressure (cSBP) has been shown to be significantly associated...
Research Article

Acute changes in arterial stiffness following exercise in healthy Caucasians and South Asians

Jeyasundar Radhakrishnan, Dionne Matthew, Keiran Henderson, David A. Brodie
Pages: 6 - 16
Background: Arterial stiffness and exercise capacity are independent predictors of cardiovascular diseases. This study aims to establish the acute changes in arterial stiffness using applanation tonometry following sub-maximal exercise in Caucasians and South Asians. This study also aims to establish...
Conference Abstract

P2.4 THE INFLUENCE OF ANTIHYPERTENSIVE TREATMENT ON ARTERIAL STIFFNESS, SHEAR STRESS AND ACTIVITY OF CHOSEN MATRIX METALLOPROTEINASES

Tomasz Pizon*, Marek Rajzer, Marta Rojek, Danuta Czarnecka
Pages: 7 - 7
Objective: Comparison of therapeuthic effects of chosen antihypertensive drugs on arterial stiffness, shear stress in carotid arteries and metalloproteinases activity, moreover analysis of relationship of these variables in the course of treatment. Design and method: 95 never treated patients with HT...
Conference Abstract

P2.5 SEX-DEPENDENT DIFFERENCES IN OBESITY INDICES AND INFLAMMATORY MARKERS IN NON-DIABETIC OBESE PATIENTS

Mariusz Stępień*, Anna Stępień, Rafał N. Wlazeł, Marek Paradowski, Maciej Banach, Jacek Rysz
Pages: 7 - 7
Background: The aim of the study was to asses sex-dependent differences of obesity indices and inflammatory markers in non-diabetic hypertensive obese patients. Material and methods: 40 females and 25 males aged 59.8 ±10.1 and 54.6±11.9 years, respectively, were enrolled into the study. Serum TNF-α,...
Conference Abstract

P2.6 PWV IS AN INDEPENDENT DETERMINANT OF COGNITIVE DYSFUNCTION IN CKD PATIENTS

Despina Karasavvidou*, Dimitrios Stagikas, Kosmas Pappas, Stylianos Lampropoulos, Cristos katsinas, Rigas kalaitzidis
Pages: 7 - 7
Objectives: In the general population aortic stiffening assessed by carotid femoral pulse wave velocity (cf-PWV) is associated with cognitive dysfunction (CO/DY). Data in chronic kidney disease (CKD) are limited. Our study tests the hypothesis that large artery stiffness and microvascular damage in CKD...
Conference Abstract

P2.7 AMELIORATION OF COGNITIVE FUNCTION IN HEMODIALYSIS PATIENTS IN ABSENT OF HYPOTENSIVES EPISODES

Despina Karasavvidou*, Eleni Triantafilidou, Dimitrios Valoukas, Dimitrios Makridis, Sygliti-Errieta Pelidou, Cristos katsinas
Pages: 7 - 8
Objective: Patients in hemodialysis frequently have cognitive dysfunction (CO/DY). Hemodialysis session often results in acute intravascular volume loss, fluid shifts, hypotensives episodes, decrease of cerebral perfusion and cerebral ischemia, all of which may cause transient deterioration of cognitive...
Research Article

Differences in photoplethysmography morphological features and feature time series between two opposite emotions: Happiness and sadness

Fei Li, Licai Yang, Hongyu Shi, Chengyu Liu
Pages: 7 - 13
It has been well established that change in emotion state is associated with the change in physiological signals. This paper aimed to investigate the differences of finger photoplethysmography (PPG) morphological features and feature time series between happiness and sadness emotion states. Fifty-three...
Mini Review

Wave reflection: Myth or reality?

Patrick Segers, Jonathan Mynard, Liesbeth Taelman, Sebastian Vermeersch, Abigail Swillens
Pages: 7 - 11
Research Article

Acute and chronic effects of acupuncture on radial artery: A randomized double blind study in migraine

Pierre Boutouyrie, Robert Corvisier, Kim-Than Ong, Claire Vulser, Catherine Lassalle, Michel Azizi, Brigitte Laloux, Stéphane Laurent
Pages: 7 - 14
Background: Acupuncture is an accepted treatment for migraine. Palpation of the radial pulses is one of the most important techniques in traditional Chinese medicine both for diagnosis and monitoring of treatment efficacy. The objective of the present study was to investigate the acute and chronic effects...
Research Article

The Prognostic Role of Aortic Stiffness in Patients Hospitalized for an Acute Heart Failure Syndrome

Sophia Giannitsi, Mara Bougiakli, Aris Bechlioulis, Anna Kotsia, Lampros Lakkas, Ioannis Girdis, Konstantinos Pappas, Georgios Chasiotis, Eleni Bairaktari, Andreas Kalogeropoulos, Lampros K. Michalis, Katerina K. Naka
Pages: 7 - 13
Background: Although impaired arterial function has been associated with adverse prognosis in chronic Heart Failure (HF), its role in Acute HF Syndromes (AHFS) has been little studied. We prospectively investigated the prognostic role of arterial function on mortality and HF Hospitalizations (HHF) in...
Conference Abstract

P2.9 A NOVEL SPECKLE TRACKING TECHNIQUE FOR INVESTIGATING REGIONAL MOTION OF THE CAROTID WALL: SPATIO-TEMPORAL VARIATION IN DISTENSION ASSOCIATES WITH PRESENCE OF CALCIFIED PLAQUE

Benyu Jiang*, Jing Wang, Tim Spector, Phil Philip J. Chowienczyk
Pages: 8 - 8
Background: Arterial calcification may lead to regional variation in distension imposing stresses on the arterial wall that predispose to plaque rupture. The objective of this study was to use a novel speckle tracking method to investigate regional motion of the carotid wall and to determine whether...
Conference Abstract

P2.10 EXAGGERATED EXERCISE BLOOD PRESSURE INDEPENDENTLY PREDICTS INCIDENT HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

Martin Schultz*, Petr Otahal, Dean Picone, James Sharman
Pages: 8 - 8
Background: Exaggerated exercise blood pressure (EEBP) independently predicts cardiovascular (CV) events and mortality, but reasons underlying this increased CV risk are unclear. The association between an EEBP and incident hypertension (as a potential underlying risk factor) has been reported, but there...
Conference Abstract

P2.11 EXERCISE REVEALS DIFFERENTIAL COUPLING BETWEEN AORTIC HAEMODYNAMICS AND LEFT VENTRICULAR TWIST MECHANICS

Martin Schultz*, Justin Davies, Eric Stöhr
Pages: 8 - 8
Background: Hypertensive heart disease is characterised by raised left ventricular (LV) mass, a consequence of load-altered ventricular-arterial coupling. Prior to gains in LV mass, early functional changes in ventricular-arterial coupling must occur, however, these are difficult to detect from conventional...
Conference Abstract

P2.12 A NOVEL MARKER EXPRESSES THE EFFECT OF THE NONLINEARITY IN THE ARTERIAL PRESSURE-VOLUME RELATIONSHIP ON THE PULSE PRESSURE: CHARACTERISTICS AND PROGNOSTIC SIGNIFICANCE IN HYPERTENSIVE PATIENTS

Benjamin Gavish*, Michael Bursztyn
Pages: 8 - 9
Arterial pressure-volume relationship frequently deviates from the linearity expected from an ideal elastic tube. As a result, pulse pressure (PP) can be split into an ‘elastic’ component (elPP) and an excess value PP-elPP. We define the ratio (PP-elPP)/elPP as arterial nonlinearity marker (NLM). OBJECTIVE:...
Research Article

Gender differences in bicycle exercise stress echocardiography testing

Karsten Keller, Kathrin Stelzer, Martin Geyer, Thomas Münzel, Mir Abolfazl Ostad
Pages: 8 - 16
Background: Sex-specific differences for myocardial infarction and coronary artery disease (CAD) have been reported in several studies. The aim of our present study was to identify gender-specific differences regarding bicycle-exercise-stress-echocardiography. Methods: We compared 87 (69.0%) male and...
Short Communication

Sex differences in the LDL receptor knockout mouse model of atherosclerosis

Neel A. Mansukhani, Zheng Wang, Vera P. Shively, Megan E. Kelly, Janet M. Vercammen, Melina R. Kibbe
Pages: 8 - 11
Review Article

Central pressure should not be used in clinical practice

Gary F. Mitchell
Pages: 8 - 13
The heart, brain and kidneys are key targets of pulsatile damage in older people and in patients with longstanding hypertension. These central organs are exposed to central systolic and pulse pressures, which may differ from the corresponding peripheral pressures measured in the brachial artery. Studies...
Research Article

Cholesterol metabolism, endothelial dysfunction, and carotid artery stiffness in type 1 diabetes

Timo Koponen, Maarit Hallikainen, Jukka Lipponen, Tiina Lyyra-Laitinen, Pasi A. Karjalainen, Mika P. Tarvainen, Chaiyasit Sittiwet, Tatu A. Miettinen, Tomi Laitinen, Helena Gylling
Pages: 8 - 14
Background: Type 1 diabetes is associated with increased risk of cardiovascular diseases and altered metabolism of cholesterol. We studied whether the markers of arterial stiffness reflecting preclinical atherosclerosis are related to markers of cholesterol metabolism in type 1 diabetes. Methods: In...
Conference Abstract

P2.13 BLOOD PRESSURE PROFILE CHANGES BETWEEN 7TH AND 11TH YEAR OF LIFE IN CHILDREN BORN PREMATURELY WITH EXTREMELY LOW BIRTH WEIGHT IN COMPARISON TO CHILDREN BORN ON TIME

Maja Gilarska*, Malgorzata Klimek, Dorota Drozdz, Andrzej Grudzien, Przemko Kwinta
Pages: 9 - 9
There have been research trials analyzing the impact of prematurity on the prevalence of hypertension, however the prospective, long-time observation is uncommon. The aim of this study was to evaluate the prevalence of hypertension at the age of 7 and 11 years of regional cohort of preterms with birth...
Conference Abstract

P2.14 PARAMETERS OF ARTERIAL STIFFNESS IN OSTEOARTHRITIS PATIENTS AND IN HEALTHY CONTROLS

Kaspar Tootsi*, Aare Märtson, Mihkel Zilmer, Kaido Paapstel, Jaak Kals
Pages: 9 - 9
Osteoarthritis (OA) and cardiovascular diseases (CVD) are prevalent conditions and often co-exist. Vascular involvement in pathogenesis of CVD and OA gives reason to investigate arterial stiffness in OA. The aim of this study is to investigate the associations between OA and arterial stiffness. Arterial...
Conference Abstract

P2.15 IRRITABLE AFFECTIVE TEMPERAMENT IS A PREDICTOR OF PULSE WAVE VELOCITY, WHEREAS HYPERTHYMIC AFFECTIVE TEMPERAMENT DETERMINES AUGMENTATION INDEX IN CHRONIC HYPERTENSION

János Nemcsik*, Andrea László, Péter Torzsa, Beáta Kőrösi, Dániel Eörsy, Orsolya Cseprekál, András Tislér, Zsófia Nemcsik-Bencze, Xénia Gonda, Zoltán Rihmer
Pages: 9 - 9
Background: Affective temperaments (anxious, depressive, cyclothymic, irritable and hyperthymic) are subclinical manifestations of major mood disorders and there is cumulating evidence about their involvement is somatic disorders as well. The aim of our study was to evaluate the associations of affective...
Conference Abstract

P2.17 FEASIBILITY OF USING COMPLIOR ANALYSE TO MEASURE CENTRAL SYSTOLIC BLOOD PRESSURE DURING DIALYSIS

Mabrouk Brahimi, Martine Catherine, Nathalie Stocard, Rachid Mojaat, Charles Chazot, Sandrine Millasseau*, Denis Chemla
Pages: 9 - 10
Central systolic blood pressure (cSBP) could be helpful to monitor hypotension during dialysis. However most cSBP devices are based on peripheral estimates which might be unreliable during the specific hemodynamic state of dialysis. Complior Analyse (Alam Medical, France) presents the advantage of measuring...
Research Article

Arterial baroreflex sensitivity: Relationship with peripheral chemoreflex in patients with chronic heart failure

Nikita Trembach, Igor Zabolotskikh
Pages: 9 - 15
Background: The purpose of this study was to evaluate the relationship between the breath-holding duration and the sensitivity of the arterial baroreflex, as well as the prognostic value of the breath-holding test in the assessment of decreased baroreflex sensitivity (BRS) in patients with chronic heart...
Review Article

Cardioliths in 19th century medical literature

Gregory Tsoucalas, Theodoros G. Papaioannou, Charalampos Vlachopoulos, Marianna Karamanou
Pages: 9 - 13
During 19th century the term “cardiolith” was widely used to describe a cluster of cardiac entities that could cause sudden death. Blood clots, polypoid growths, microorganisms and inflammation were implicated. Scientists of the era described formations that could enter any heart chamber after having...
Research Article

A unified mechanism for the water hammer pulse and pulsus bisferiens in severe aortic regurgitation: Insights from wave intensity analysis

Julio A. Chirinos, Scott R. Akers, Jan A. Vierendeels, Patrick Segers
Pages: 9 - 12
The carotid bisferiens pulse and the radial water hammer pulse are typical of severe chronic aortic regurgitation. Little is known about the mechanism of these classic cardiovascular signs identified on physical examination. We report the first characterization of these abnormal pulse patterns using...
Research Article

Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population

Ljupcho Efremov, Wen-Yi Yang, Lotte Jacobs, Lutgarde Thijs, Tatiana Kuznetsova, Harry A.J. Struijker-Boudier, Jan A. Staessen
Pages: 9 - 17
Introduction: Common carotid artery (CCA) intima-media thickness (IMT), lumen diameter, and maximum plaque thickness were assessed on ultrasound images. The objective of the study was to evaluate the intra- and inter-reader reproducibility of the measurements following a standardised protocol. Methods:...
Research Article

Patients with refractory angina have increased aortic wave reflection and wasted left ventricular pressure energy

Alvaro N. Gurovich, Wilmer W. Nichols, Randy W. Braith, C. Richard Conti
Pages: 9 - 15
Background: Early return of reflected blood pressure (BP) waves from the lower body augments central systolic BP and increases systolic pressure-time index (SPTI) and wasted left ventricular (LV) pressure energy, which increase afterload and myocardial oxygen (MVO2) demand. Accordingly, we sought to...
Review Article

Magnetic resonance imaging in vascular biology☆

Matthias Voehringer, Udo Sechtem, Matthias G. Friedrich
Pages: 9 - 20
Symptoms are only the tip of the iceberg in atherosclerotic disease. Beneath the surface are multiple patho-physiological processes taking place in and around the vessel wall. The increasing knowledge in the field of vascular biology also reveals new imaging targets as biological markers of the disease....
Review Article

Marfan and Marfan-like syndromes

J. De Backer, B. Loeys, A. De Paepe
Pages: 9 - 16
With the help of both clinical and genetic diagnostic tools, the spectrum of inherited disorders affecting the arterial system has extended tremendously over the past decades. Discriminating these different entities is important since prognosis and treatment may differ substantially according to the...
Conference Abstract

P2.18 IMPACT OF CARDIOVASCULAR RISK FACTORS ON CAROTID STIFFNESS AND CAROTID INTIMA MEDIA THICKNESS – GENDER DIFFERENCES

Maria Loboz-Rudnicka*, Joanna Jaroch, Zbigniew Bociaga, Barbara Rzyczkowska, Ewa Kruszynska, Krystyna Loboz-Grudzien, Andrzej Szuba
Pages: 10 - 10
Background and purpose: Whether the influence of risk factors on carotid stiffness (CS) and carotid intima media thickness (CIMT) is modulated by gender is still unclear. The aim of our study was to examine the association between cardiovascular (CV) risk factors, CS and CIMT in men and women. Material...
Conference Abstract

P2.19 COMPARISON OF BRACHIAL AND CENTRAL BLOOD PRESSURES FROM 2 SPHYGMOCOR XCEL SYSTEMS EQUIPPED WITH A 2M AND 6M-LONG HOSE

S. Stoer, G. Soulat, S. Tavolaro, S. Millasseau, H. Khettab, P. Boutouyrie, S. Laurent, E. Mousseaux*
Pages: 10 - 10
Background and aim: Magnetic resonance imaging (MRI) provides excellent anatomical coverage for local and regional indices of aortic function and structure. However, blood pressure (BP) assessments is usually necessary for the calculation of these functional MRI parameters. Unfortunately, most pressure...
Conference Abstract

P2.20 PERIPHERAL ARTERY DISEASE DETECTED BY ANKLE-BRACHIAL INDEX IS ASSOCIATED TO CARDIAC AND CAROTID ABNORMALITIES IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES

José Pompeu Filho, Ricardo Silva, Rachel Andrade, Leiria Andrade Neto, João Falcão, Sandra Falcão, Luiz Bortolotto*
Pages: 10 - 10
Few studies evaluated cardiac or carotid abnormalities in patients with arterial hypertension and diabetes according to the presence of peripheral artery disease detected by abnormal ankle brachial index (ABI). For this purpose, we studied 99 diabetic hypertensive patients with abnormal (n=50, ABI≤0.9...
Conference Abstract

P3.1 SUB-MAXIMAL EXERCISE BLOOD PRESSURE RELATES TO LEFT VENTRICULAR MASS INDEX, BUT IS DEPENDENT ON LOW AEROBIC CAPACITY

Martin Schultz*, Dean Picone, Rachel Climie, Costan Magnussen, Leah Wright, Thomas Marwick, Alison Venn, James Sharman
Pages: 10 - 11
Background: Exaggerated blood pressure (BP) responses to sub-maximal exercise independently predict cardiovascular (CV) events, mortality and incident hypertension. The aim of this study was to explore relationships between exercise BP, left-ventricular (LV) structure and function and aerobic fitness...
Review Article

Arterial stiffness: From surrogate marker to therapeutic target☆

Luc Van Bortel
Pages: 10 - 14
Carotid-femoral (aortic) pulse wave velocity (PWV) is the modern benchmark for the assessment of arterial stiffness. Current European hypertension guidelines acknowledge the good cardiovascular (CV) predictive value, reproducibility and cost-effectiveness of PWV. Aortic PWV is an asset to classical cardiovascular...
Research Article

In silico characterization of the effects of size, distribution, and modulus contrast of aortic focal softening on pulse wave propagations

Igor Inga, Danial Shahmirzadi
Pages: 10 - 18
Examining the change in regional stiffness of the arterial wall may prove as a reliable method for detecting various cardiovascular diseases. As suggested by Moens–Korteweg relationship, the pulse wave velocity (PWV) along the arteries has been shown to correlate to the stiffness of the arterial wall;...