In vitro characterisation of arterial stiffening: From the macro- to the nano-scale
- https://doi.org/10.1016/j.artres.2014.01.002How to use a DOI?
- Material properties; In vitro mechanical testing; Arterial stiffening; Tensile testing; Nanoindentation; Atomic force microscopy; Scanning acoustic microscopy; Ageing
Accurate measurement of the material properties of arterial tissue is important for better characterisation of diseases and the development of reliable computational models. There are a number of in vitro techniques that are applied to study the biomechanical properties of arterial tissue. This review article presents data obtained using tensile testing, nanoindentation, scanning acoustic microscopy (SAM) and atomic force microscopy (AFM). Each of these techniques provides material property information at a different spatial resolution and in many ways are complementary techniques. The lack of consensus in the literature with regard to the appropriate stress and strain definitions that should be used when reporting tensile testing data is also highlighted. The potential of higher spatial resolution techniques, which provide data at micro-scale (nanoindentation and SAM) and nano-scale (AFM) for application to the characterisation of human aortic tissue are discussed. Finally, studies, which have examined age-related changed in the aorta at these different length scales, are highlighted.
- © 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - JOUR AU - Riaz Akhtar PY - 2014 DA - 2014/01/26 TI - In vitro characterisation of arterial stiffening: From the macro- to the nano-scale JO - Artery Research SP - 1 EP - 8 VL - 8 IS - 1 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2014.01.002 DO - https://doi.org/10.1016/j.artres.2014.01.002 ID - Akhtar2014 ER -