Volume 8, Issue 1, March 2014
Pages: 1 - 8
Accurate measurement of the material properties of arterial tissue is important for better characterisation of diseases and the development of reliable computational models. There are a number of in vitro techniques that are applied to study the biomechanical properties of arterial tissue. This review...
2. Patients with refractory angina have increased aortic wave reflection and wasted left ventricular pressure energy
Alvaro N. Gurovich, Wilmer W. Nichols, Randy W. Braith, C. Richard Conti
Pages: 9 - 15
Background: Early return of reflected blood pressure (BP) waves from the lower body augments central systolic BP and increases systolic pressure-time index (SPTI) and wasted left ventricular (LV) pressure energy, which increase afterload and myocardial oxygen (MVO2) demand. Accordingly, we sought to...
3. Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused ApoE−/− mice
Bram Trachet, M. Renard, C. Van der Donckt, S. Deleye, J. Bols, G.R.Y. De Meyer, S. Staelens, B.L. Loeys, P. Segers
Pages: 16 - 23
Purpose: To explore new imaging techniques to elucidate some of the differences between both abdominal and ascending aortic aneurysms in the angiotensin II mouse model. Procedures: Angiotensin II-infusing pumps were implanted in male ApoE−/− mice (n = 10). In vivo micro-CT, ultrasound and Positron emission...
4. Evaluation of losmapimod in patients with chronic obstructive pulmonary disease (COPD) with systemic inflammation stratified using fibrinogen (‘EVOLUTION’): Rationale and protocol
M. Fisk, D. Mohan, J. Cheriyan, L. Yang, J. Fuld, C.M. McEniery, R. Tal-Singer, M.I. Polkey, I.B. Wilkinson
Pages: 24 - 34
Introduction: p38 mitogen-activated protein kinases (MAPK) are key signalling molecules in cellular responses to external stresses, regulate pro-inflammatory cytokine expression and are implicated in the inflammatory pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) and atherosclerosis. The...