Artery Research

Volume 17, Issue C, March 2017, Pages 1 - 15

Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value

Authors
Bryan Williamsa, b, *, Patrick Brunelc, Peter S. Lacya, b, Fabio Baschierac, Dion H. Zapped, Kazuomi Karioe, John Cockcroftf
aInstitute of Cardiovascular Science, University College London, London, W1T 7DN, UK
bNational Institute for Health Research, University College London Hospitals Biomedical Research Centre, London, W1T 7DN, UK
cNovartis Pharma AG, CH-4002, Basel, Switzerland
dNovartis Pharmaceuticals Corporation, East Hanover, NJ, USA
eJichi Medical School, Tochigi, 329-0498, Japan
fDepartment of Cardiology, University of Cardiff, CF 14 4XN, Wales, UK
*Corresponding author. Institute of Cardiovascular Science, University College London, London, W1T 7DN, UK. E-mail address: bryan.williams@ucl.ac.uk (B. Williams).
Corresponding Author
Bryan Williams
Received 21 March 2016, Revised 5 October 2016, Accepted 19 October 2016, Available Online 5 December 2016.
DOI
https://doi.org/10.1016/j.artres.2016.10.154How to use a DOI?
Keywords
Arterial stiffness, Applanation tonometry, Central aortic pressure, Clinical outcomes, Hemodynamics, Pulse waveform analysis, Wave reflection
Abstract

Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular (CV) events. However, recent clinical evidence suggests that central aortic pressure (CAP) provides additional information for assessing CV risk than brachial blood pressure (BrBP). Central hemodynamics can now be non-invasively assessed with a number of devices, however, the methodology employed to measure CAP, in order to better identify the patients at higher CV risk in clinical practice, is still controversial. The purpose of this article is to review the technology behind the non-invasive measurement of CAP via the effects of different classes of antihypertensive drugs on CAP and the data supporting the predictive value of assessing CAP on clinical outcomes, and to foster the transfer of methodological knowledge from clinical trials into routine clinical practice.

Copyright
© 2016 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
17 - null
Pages
1 - 15
Publication Date
2016/12
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.1016/j.artres.2016.10.154How to use a DOI?
Copyright
© 2016 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Bryan Williams
AU  - Patrick Brunel
AU  - Peter S. Lacy
AU  - Fabio Baschiera
AU  - Dion H. Zappe
AU  - Kazuomi Kario
AU  - John Cockcroft
PY  - 2016
DA  - 2016/12
TI  - Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value
JO  - Artery Research
SP  - 1
EP  - 15
VL  - 17
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.154
DO  - https://doi.org/10.1016/j.artres.2016.10.154
ID  - Williams2016
ER  -