Noninvasive evaluation of varying pulse pressures in vivo using brachial sphymomanometry, applanation tonometry, and Pulse Wave Ultrasound Manometry

Ronny X. Li; Ada Ip; Elena Sanz-Miralles; Elisa E. Konofagou

doi:10.1016/j.artres.2017.02.002

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Volume 18, Issue C, June 2017, Pages 22 - 28

Noninvasive evaluation of varying pulse pressures in vivo using brachial sphymomanometry, applanation tonometry, and Pulse Wave Ultrasound Manometry

Authors

Ronny X. Li^a, Ada Ip^a, Elena Sanz-Miralles^b, Elisa E. Konofagou^a^{, c}^{, *}

^aUltrasound and Elasticity Imaging Laboratory, Department of Biomedical Engineering, Columbia University, New York, NY, USA

^bDepartment of Dental Medicine, Columbia University Medical Center, New York, NY, USA

^cDepartment of Radiology, Columbia University Medical Center, New York, NY, USA

^*Corresponding author. Ultrasound and Elasticity Imaging Laboratory, Columbia University, 630 W 168th St., Physicians & Surgeons 19-418, New York, NY 10032, USA. Fax: +1 212 342 1648. E-mail address: ek2191@columbia.edu (E.E. Konofagou).

Corresponding Author

Elisa E. Konofagou

Received 29 November 2016, Accepted 7 February 2017, Available Online 10 March 2017.

DOI: 10.1016/j.artres.2017.02.002 How to use a DOI?
Keywords: Abdominal aorta; Blood pressure; Central pulse pressure; Elastography; Hypertension; Pulse wave imaging; Pulse wave velocity; Ultrasound imaging
Abstract: The routine assessment and monitoring of hypertension may benefit from the evaluation of arterial pulse pressure (PP) at more central locations (e.g. the aorta) rather solely at the brachial artery. Pulse Wave Ultrasound Manometry (PWUM) was previously developed by our group to provide direct, noninvasive aortic PP measurements using ultrasound elasticity imaging. Using PWUM, radial applanation tonometry, and brachial sphygmomanometry, this study investigated the feasibility of noninvasively obtaining direct PP measurements at multiple arterial locations in normotensive, pre-hypertensive, and hypertensive human subjects. Two-way ANOVA indicated a significantly higher aortic PP in the hypertensive subjects, while radial and brachial PP were not significantly different among the subject groups. No strong correlation (r² < 0.45) was observed between aortic and radial/brachial PP in normal and pre-hypertensive subjects, suggesting that increases in PP throughout the arterial tree may not be uniform in relatively compliant arteries. However, there was a relatively strong positive correlation between aortic PP and both radial and brachial PP in hypertensive subjects (r² = 0.68 and 0.87, respectively). PWUM provides a low-cost, non-invasive, and direct means of measuring the pulse pressure in large central arteries such as the aorta. When used in conjunction with peripheral measurement devices, PWUM allows for the routine screening of hypertension and monitoring of BP-lowering drugs based on the PP from multiple arterial sites.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 18 - C
Pages: 22 - 28
Publication Date: 2017/03/10
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.02.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Ronny X. Li
AU  - Ada Ip
AU  - Elena Sanz-Miralles
AU  - Elisa E. Konofagou
PY  - 2017
DA  - 2017/03/10
TI  - Noninvasive evaluation of varying pulse pressures in vivo using brachial sphymomanometry, applanation tonometry, and Pulse Wave Ultrasound Manometry
JO  - Artery Research
SP  - 22
EP  - 28
VL  - 18
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.02.002
DO  - 10.1016/j.artres.2017.02.002
ID  - Li2017
ER  -

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