Pulse pressure measured at the level of the femoral artery, but not at the level of the aorta, carotid and brachial arteries, is associated with the incidence of coronary heart disease events in a population with a high prevalence of type 2 diabetes and impaired glucose metabolism – The Hoorn study

A.D. Protogerou; T.T. van Sloten; R.M.A. Henry; J.M. Dekker; Giel Nijpels; C.D.A. Stehouwer

doi:10.1016/j.artres.2014.12.003

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Volume 9, Issue C, March 2015, Pages 19 - 26

Pulse pressure measured at the level of the femoral artery, but not at the level of the aorta, carotid and brachial arteries, is associated with the incidence of coronary heart disease events in a population with a high prevalence of type 2 diabetes and impaired glucose metabolism – The Hoorn study

Authors

A.D. Protogerou^a^{, b}^{, *}, T.T. van Sloten^a^{, b}^{, c}, R.M.A. Henry^a^{, b}, J.M. Dekker^d^{, e}, Giel Nijpels^d, C.D.A. Stehouwer^a^{, b}

^aDepartment of Medicine, Maastricht University Medical Center, Maastricht, Netherlands

^bDepartment of Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, Netherlands

^cDepartment of School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, Netherlands

^dEMGO Institute for Health and Care Research, Netherlands

^eDepartment of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands

^*Corresponding author. Maastricht University Medical Center, Dept. of Medicine, Prof. Debyelaan 25, 6229 HX Maastricht, Netherlands. Tel.: +31 43 3871562; fax: +31 43 3875006. E-mail address: a.protogerou@maastrichtuniversity.nl (A.D. Protogerou).

Corresponding Author

A.D. Protogerou

Received 18 July 2014, Revised 11 December 2014, Accepted 22 December 2014, Available Online 9 January 2015.

DOI: 10.1016/j.artres.2014.12.003 How to use a DOI?
Keywords: Central blood pressure; Femoral artery; Pulse pressure; Coronary heart disease; Cardiovascular disease; Type 2 diabetes mellitus
Abstract: Introduction: Central (aortic or carotid) pulse pressure (PP) is more strongly associated with local organ damage and possibly mortality than brachial PP.

Aim: To investigate for the first time the association of femoral (f) PP with all-cause mortality, and incident cardiovascular disease (CVD), coronary heart disease (CHD) and cerebrovascular disease (CerVD) events, as well as with markers of renal function (estimated glomerular filtration rate, eGFR, and microalbuminuria).

Methods: We used data from a population-based study, by design including 50% type 2 diabetes and impaired glucose metabolism (IGM). The baseline examination included non-invasive PP assessment at the brachial, aorta (Sphygmocor device), carotid and femoral (ultrasound distention waves calibrated by brachial mean and diastolic pressure) arteries.

Results: After 7.8 years of follow-up (n = 449, age: 68.9 ± 6.0 males: 52%), 66 participants had died, 102 had a CVD event, 45 a CHD event, and 31 a CerVD event. PP at all sites was associated with incident all-cause mortality and CVD events. Only fPP was, however, associated with incident CHD events, even after adjustment for CVD risk factors (HRs 1.31 [1.07–1.61 95% CIs]). No association between PP and incident CerVD events was found – possibly due to the small number of events. fPP was associated with renal function but this was similar to other PP indices. No interaction between each any local PP index and glucose metabolism status or renal function was present.

Conclusion: Beyond anatomical topography, local fPP provide important information related to CVD events. This possibility and the underlying mechanisms should be further investigated.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 9 - C
Pages: 19 - 26
Publication Date: 2015/01/09
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.12.003 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - A.D. Protogerou
AU  - T.T. van Sloten
AU  - R.M.A. Henry
AU  - J.M. Dekker
AU  - Giel Nijpels
AU  - C.D.A. Stehouwer
PY  - 2015
DA  - 2015/01/09
TI  - Pulse pressure measured at the level of the femoral artery, but not at the level of the aorta, carotid and brachial arteries, is associated with the incidence of coronary heart disease events in a population with a high prevalence of type 2 diabetes and impaired glucose metabolism – The Hoorn study
JO  - Artery Research
SP  - 19
EP  - 26
VL  - 9
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.12.003
DO  - 10.1016/j.artres.2014.12.003
ID  - Protogerou2015
ER  -

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