Adiponectin negatively correlated with carotid arterial structure in the leptin-resistant Zucker diabetic fatty rat

Emmanuel Cosson; Paul Valensi; André Bado; Hubert Dabiré

doi:10.1016/j.artres.2011.08.001

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Adiponectin negatively correlated with carotid arterial structure in the leptin-resistant Zucker diabetic fatty rat

Authors

Emmanuel Cosson^a^{, b}^{, c}, Paul Valensi^b^{, c}, André Bado^d, Hubert Dabiré^a^{, *}

^aINSERM U 955, Eq03 – IMRB, ENVA - Bâtiment Ferrando, 7 Avenue du Général de Gaulle, Maisons-Alfort F-94704, France

^bParis-Nord University, Laboratory of Nutrition, Metabolic Diseases and Cardiovascular Prevention, CRNH-IdF, Bobigny 93140, France

^cAP-HP, Department of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, Bondy 93140, France

^dINSERM U773, CRB3 – Equipe 2, Paris 75890, France

^*Corresponding author. Tel.: +33 1 43 96 73 87; fax: +33 1 43 96 73 99. E-mail addresses: hdabire@vet-alfort.fr, hubert.dabire@inserm.fr (H. Dabiré).

Corresponding Author

Hubert Dabiré

Received 22 June 2011, Revised 29 July 2011, Accepted 1 August 2011, Available Online 19 August 2011.

DOI: 10.1016/j.artres.2011.08.001 How to use a DOI?
Keywords: Leptin; Adiponectin; Luminal cross-sectional area; Medial cross-sectional area; Wall stress; Zucker diabetic fatty rats
Abstract: Background: Despite adipocytokines are implicated in arterial hemodynamic and stiffness, their effects on arterial histomorphometry remain poorly explored. The aim of the present study was to evaluate, in Zucker Diabetic Fatty (ZDF) rats, a model of type 2 diabetes with leptin resistance, carotid arterial structural changes and their determinants, with special focus on adiponectin and leptin.

Methods: Proximal aortic blood pressure (BP) was measured in conscious ZDF rats (n = 6–8) and their Lean controls (n = 6–8) at 6, 12 and 24 weeks. The contralateral carotid was harvested and fixed at the mean BP for histomorphometric quantification.

Results: Mean BP was similar in both strains and increased with age (p < 0.001). Medial thickness, luminal cross-sectional area (LCSA), medial cross-sectional area (MCSA) and wall stress (WS) increased with age (p < 0.001). LCSA and WS were higher in Lean than in ZDF rats (p < 0.001 for both). Leptin levels were higher in ZDF than in Lean rats (p < 0.001) but remained unchanged during development in ZDF rats. Adiponectin levels decreased with age in ZDF rats (p < 0.001) but remained unchanged in Lean rats. In all rats, adiponectin negatively correlated with medial thickness (r = −0.50, p < 0.01), LCSA (r = −0.64, p < 0.001), MCSA (r = −0.59, p < 0.001) and WS (r = −0.43, p < 0.05). These correlations were significant (p < 0.001) in ZDF rats considered separately (r = −0.73, r = −0.87, r = −0.83 and r = −0.79, respectively) but not in Lean rats; independently of mean BP and age after stepwise regression analyses.

Conclusion: These associations suggest a protective role for adiponectin against arterial wall thickening and wall stress. However for causal relation, further investigation is needed.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 6 - 1
Pages: 12 - 20
Publication Date: 2011/08/19
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.08.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Emmanuel Cosson
AU  - Paul Valensi
AU  - André Bado
AU  - Hubert Dabiré
PY  - 2011
DA  - 2011/08/19
TI  - Adiponectin negatively correlated with carotid arterial structure in the leptin-resistant Zucker diabetic fatty rat
JO  - Artery Research
SP  - 12
EP  - 20
VL  - 6
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.08.001
DO  - 10.1016/j.artres.2011.08.001
ID  - Cosson2011
ER  -

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