Aortic calcification, arterial stiffness and bone mineral density in patients with COPD☆
The work was carried out at Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UK.
- https://doi.org/10.1016/j.artres.2011.01.001How to use a DOI?
- Aortic stiffness, Pulse wave velocity, Osteoporosis, Lung function
Background: Increased arterial stiffness, using aortic pulse wave velocity (PWV) has been demonstrated in patients with COPD. However, mechanisms underlying this remain unclear. We explored the contribution of aortic calcification to large artery haemodynamics and its association to bone mineral density (BMD) in patients with confirmed COPD.
Methods: Patients with COPD, free of maintenance oral corticosteroids, renal disease, diabetes or known cardiovascular disease (n = 45), 27 male, mean (SD) age 66(7) years underwent unenhanced thoraco-abdominal computed tomography to determine quantitative aortic calcium content using a volume scoring method. Aortic PWV was measured. A subgroup (n = 29) had BMD determined.
Results: All patients had some evidence of aortic calcification. Aortic PWV was related to log10 calcification in abdominal aorta (r = 0.34, p = 0.025) and to semi-quantitative assessment in the ascending and descending thoracic aorta (r = 0.47 and r = 0.39, both p < 0.01). Log10 calcium was inversely related to BMD hip (r = −0.43), p = 0.02. Both aortic PWV and log10 calcium were related to age, which on multiple regression was the independent variable.
Conclusions: Aortic calcification is related to aortic stiffness, an independent predictor of cardiovascular mortality and morbidity, and inversely to BMD in patients with COPD. Given, both cardiovascular disease and osteoporosis are common in patients with COPD, determining underlying mechanisms are essential as potential therapeutic targets.
- © 2011 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
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Cite this article
TY - JOUR AU - Charlotte E. Bolton AU - Carmel M. McEniery AU - Vimal Raj AU - Barry J. McDonnell AU - Adrian K. Dixon AU - Margaret Munnery AU - Ramsey Sabit AU - Nicholas Screaton AU - Michael Stone AU - Ian B. Wilkinson AU - Dennis J. Shale AU - John R. Cockcroft PY - 2011 DA - 2011/02 TI - Aortic calcification, arterial stiffness and bone mineral density in patients with COPD☆ JO - Artery Research SP - 30 EP - 36 VL - 5 IS - 1 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.01.001 DO - https://doi.org/10.1016/j.artres.2011.01.001 ID - Bolton2011 ER -