Artery Research

Volume 5, Issue 4, December 2011, Pages 144 - 144

5.6 INDEPENDENT RELATION BETWEEN ETHNICITY, BASELINE HAEMOSTATIC VARIABLES, ARTERIAL STIFFNESS AND MORTALITY: A 22-YEAR FOLLOW-UP STUDY

Authors
S.G. Anderson1, A.H. Heald1, J.K. Cruickshank2
1University of Manchester, Manchester, United Kingdom
2King’s College London, London, United Kingdom
Available Online 29 November 2011.
DOI
10.1016/j.artres.2011.10.224How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objectives: To examine the relationship between haemostatic factors, pulse wave velocity (PWV), blood pressure (BP) and mortality in British Europeans, African-Caribbeans (AfC) and Gujarati Indians.

Design and Methods: Prospective cohort study of 331 subjects (40–79 years), followed-up over 21 years for mortality. PWV, Apolipoprotein-A1 (Apo-A1), apolipoprotein-B (Apo-B), factor VIIc (FVIIc), fibrinogen and vWF were measured at baseline in 118 Europeans, 100 AfC and 113 Gujaratis.

Results: 113 (34%) subjects died during a mean of 16.8 years follow-up with 57 cardiovascular deaths. Women had significantly higher, and AfC males the lowest FVIIc and Apo-A1 levels. HDL levels were lowest (F = 3.13; P=0.04) in Gujarati Indians. Baseline age-sex and ethnicity adjusted FVIIc levels were higher in those who died (133.9 vs. 117.6%; P=0.03), with similar levels of the other haemostatic factors by mortality status. In similarly adjusted partial correlations, Apo-A1 was inversely related to PWV (ρ = −0.23, P=0.04). No independent associations were found between fibrinogen, FVIIc, Apo-B, ApoB/Apo-A1 ratio, vWF and PWV. In Kaplan-Meier curves (Figure 1), those above, compared with those below the median of Apo-A1 levels, had reduced mortality. In Cox regressions, SBP (per 5mmHg) was associated with a 9%, PWV a 20% (per m/s), and FVIIc a 6% (per 10-unit; HR 1.06 (1.01, 1.10, P=0.016) increased risk of mortality.

Conclusions: The relationship between haemostatic variables with cardiovascular disease is well known, however few studies report their association with arterial stiffness. The results here are consistent with the independent effect of haemostatic variables influencing arterial stiffness and mortality.

Journal
Artery Research
Volume-Issue
5 - 4
Pages
144 - 144
Publication Date
2011/11/29
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2011.10.224How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - S.G. Anderson
AU  - A.H. Heald
AU  - J.K. Cruickshank
PY  - 2011
DA  - 2011/11/29
TI  - 5.6 INDEPENDENT RELATION BETWEEN ETHNICITY, BASELINE HAEMOSTATIC VARIABLES, ARTERIAL STIFFNESS AND MORTALITY: A 22-YEAR FOLLOW-UP STUDY
JO  - Artery Research
SP  - 144
EP  - 144
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.224
DO  - 10.1016/j.artres.2011.10.224
ID  - Anderson2011
ER  -