P9.09 DIFFERENCE IN AGE-RELATED PATTERNS OF ARTERIAL STIFFNESS AND WAVE REFLECTIONS AMONG PATIENTS WITH KIDNEY DISEASE: RESULTS OF THE UK RESEARCH ALLIANCE INTO KIDNEY DISEASE AND ARTERIAL STIFFNESS (UREKA) COLLABORATION
- DOI
- 10.1016/j.artres.2010.10.101How to use a DOI?
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Background: Patients with CKD may have higher aortic PWV (aPWV) and augmentation index (AIx) but studies are limited by size and lack of control population and differences may be due to joint risk factors. We examined whether aPWV and AIx are increased in CKD patients with no vascular co-morbidities compared to controls and how change with age varies between populations.
| Kidney disease | Healthy controls | |
|---|---|---|
| Age (y) | 55±14 | 56±18 |
| Male (%)* | 66 | 48 |
| eGFR* | 43±21 | 96±30 |
| Syst/Diast BP | 133/80 ±20/11 | 134/80 ±19/11 |
| Adj PWV* | 9.0±2.5 | 7.8±1.8 |
| Adj AIx* | 26.0±9.2 | 19.3±8.5 |
Methods: Cardiovascular risk factor data, aPWV and AIx were obtained from CKD patients at 8 UK renal centres and participants in ACCT, a study of the general population. Those with diabetes and/or vascular disease were excluded. The relationship of age to aPWV and AIx was compared between patients with CKD (stages 1–5, not on dialysis, non-vascular diagnosis, n=524) and controls (eGFR >60mL/min, n=1535). Controls were stratified by age and gender to ensure comparability.
Results: Adjusted aPWV and AIx were higher in CKD patients (P<0.001). There was a significant interaction (P<0.001) between age and the presence of CKD on aPWV, but this was not seen for AIx (P=0.19).
Conclusions: Kidney disease in the absence of co-morbidities is associated with increased arterial stiffness compared to controls. In CKD patients aPWV increases more rapidly with age than controls but there was no difference in the pattern of change of AIx with age between groups.
Cite this article
TY - JOUR AU - L.A. Tomlinson AU - B. Caplin AU - S.J. Carr AU - C. Delles AU - C.J. Ferro AU - J. Goddard AU - S.G. Holt AU - P.A. Kalra AU - P.S. Lacy AU - C.M. McEniery AU - C.W. McIntyre AU - E.P. McQuarrie AU - C. Rajkumar AU - T. Savage AU - M.W. Taal AU - C.R. Tompson AU - J.N. Townend AU - D.J. Webb AU - D.C. Wheeler AU - I.B. Wilkinson PY - 2010 DA - 2010/12/02 TI - P9.09 DIFFERENCE IN AGE-RELATED PATTERNS OF ARTERIAL STIFFNESS AND WAVE REFLECTIONS AMONG PATIENTS WITH KIDNEY DISEASE: RESULTS OF THE UK RESEARCH ALLIANCE INTO KIDNEY DISEASE AND ARTERIAL STIFFNESS (UREKA) COLLABORATION JO - Artery Research SP - 174 EP - 175 VL - 4 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.10.101 DO - 10.1016/j.artres.2010.10.101 ID - Tomlinson2010 ER -