3.5 EFFECT OF SHORT-TERM TREATMENT WITH LERCANIDIPINE ON CIRCULATING ENDOTHELIAL PROGENITOR CELLS AND STRUCTURAL ALTERATIONS IN RETINAL ARTERIOLES

C. De Ciuceis; C. Rossini; E. La Boria; S. Duse; F. Semeraro; C. Agabiti Rosei; P. Airò; M. Scarsi; A. Tincani; M.L. Muiesan; A. Paini; M. Salvetti; E. Porteri; E. Agabiti Rosei; D. Rizzoni

doi:10.1016/j.artres.2012.09.023

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Volume 6, Issue 4, December 2012, Pages 146 - 146

3.5 EFFECT OF SHORT-TERM TREATMENT WITH LERCANIDIPINE ON CIRCULATING ENDOTHELIAL PROGENITOR CELLS AND STRUCTURAL ALTERATIONS IN RETINAL ARTERIOLES

Authors

C. De Ciuceis¹, C. Rossini¹, E. La Boria¹, S. Duse², F. Semeraro², C. Agabiti Rosei¹, P. Airò³, M. Scarsi³, A. Tincani³, M.L. Muiesan¹, A. Paini¹, M. Salvetti¹, E. Porteri¹, E. Agabiti Rosei¹, D. Rizzoni¹

¹Clinica Medica, Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy

²Chair of Ophthalmology, University of Brescia, Brescia, Italy

³Chair of Rheumatology, University of Brescia, Brescia, Italy

Available Online 17 November 2012.

DOI: 10.1016/j.artres.2012.09.023 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: It has been previously demonstrated that dihydropyridine calcium channel blockers may possess antioxidant properties and might improve microvascular structure. The aim of the present study was therefore to investigate the effects of a short-term treatment with lercanidipine on structural alterations in retinal arterioles and on circulating endothelial progenitor cells (EPCs), which are bone marrow-derived cells possibly participating in neovascularization and endothelial protection and repair.

Patients and Methods: Fourteen essential hypertensive patients were included in the study and treated for 4 weeks with lercanidipine 10–20 mg per day orally. Investigations were performed in basal condition, after appropriate wash out of previous treatments, and after 4 week lercanidipine treatment. EPCs were evaluated by flow cytometry as CD34+/CD133+/KDR+ cells. Non-invasive measurements of internal diameter (ID), external diameter (ED), wall thickness, wall to lumen ratio (W/L) and wall cross-sectional area (WCSA) of retinal arterioles using scanning laser doppler flowmetry (SLDF) were performed (Heidelberg Retina Flowmeter, Heidelberg Engineering), according to Harazny J et al, Hypertension 2007; 50:623–629.

Results are summarized in the Table (^*P<0.05, ^**p<0.01,^***p<0.001 vs. Basal).

A significant increase in circulating EPC count was observed after treatment with lercanidipine, associated with a reduction in W/L and an improvement of other indices of retinal artery structure, which, in the absence of a significant increase in ID, does not seem to be ascribed just to the vasodilator effect of the drug.

Conclusions: For the first time, in this study, favourable effects on the EPC-dependent endothelium-repair system and on alterations of retinal arterioles have been reported in men after treatment with a dihydropyridine calcium channel antagonist, lercanidipine, possibly related to hemodynamic and antioxidant properties.

Table	Gender (M/F)	Blood pressure (mm Hg)	EPCs	W/L
Basal	11/3	154/90±9.6/11.9	49.1±40	0.52±0.14
Treatment	-	145/78.7±10.7/10.5^/^	102±71^*	0.26±0.08^**
	ID (μm)	ED (μm)	Wall thickness (μm)	WCSA (μm²)
Basal	57.3±12.9	85.6±15.6	14.1±3.37	3232±1214
Treatment	61.1±8.05	77.1±11.7^*	7.99±2.78^***	1784±842^**

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Journal: Artery Research
Volume-Issue: 6 - 4
Pages: 146 - 146
Publication Date: 2012/11/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2012.09.023 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - C. De Ciuceis
AU  - C. Rossini
AU  - E. La Boria
AU  - S. Duse
AU  - F. Semeraro
AU  - C. Agabiti Rosei
AU  - P. Airò
AU  - M. Scarsi
AU  - A. Tincani
AU  - M.L. Muiesan
AU  - A. Paini
AU  - M. Salvetti
AU  - E. Porteri
AU  - E. Agabiti Rosei
AU  - D. Rizzoni
PY  - 2012
DA  - 2012/11/17
TI  - 3.5 EFFECT OF SHORT-TERM TREATMENT WITH LERCANIDIPINE ON CIRCULATING ENDOTHELIAL PROGENITOR CELLS AND STRUCTURAL ALTERATIONS IN RETINAL ARTERIOLES
JO  - Artery Research
SP  - 146
EP  - 146
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.023
DO  - 10.1016/j.artres.2012.09.023
ID  - DeCiuceis2012
ER  -

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