Artery Research

Volume 6, Issue 4, December 2012, Pages 146 - 146

3.6 CENTRAL PULSE PRESSURE IS AN INDEPENDENT DETERMINANT OF VASCULAR REMODELLING IN THE RETINAL CIRCULATION

Authors
C. Ott1, U. Raff1, J. Harazny1, G. Michelson2, R.E. Schmieder1
1Department of Nephrology and Hypertension, University of Erlangen-Nuremberg, Erlangen, Germany
2Department of Ophthalmology, University of Erlangen-Nuremberg, Erlangen, Germany
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.024How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: Pulse pressure has been recognized as a risk factor for stroke. Moreover, it was shown that central pulse pressure (PP) relates more strongly to vascular disease and outcome than (peripheral) brachial PP. Hence, we analyzed the impact of central PP on retinal vascular structure, mirroring cerebral circulation.

Design and methods: The study cohort comprised 135 patients across a wide range of BP, but without evidence of diabetes. Parameters of retinal arteriole structure (wall-to-lumen (WLR) and function (change of retinal capillary flow (RCF) to nitric oxide synthase inhibitor N-monomethyl-L-arginine (L-NMMA), reflecting basal NO activity of the retinal vasculature) was assessed non-invasively and in vivo by scanning laser Doppler flowmetry. Central hemodynamics and augmentation index (AIx) were assessed by pulse wave analysis.

Results: WLR was correlated with central PP (r = 0.302, p < 0.001). In accordance, PP amplification (peripheral PP/central PP) was negatively correlated with WLR (r −0.223, p = 0.009). In contrast, MAP was not correlated with WLR (r = 0.110, p = 0.203). Moreover, AIx@75 correlated with WLR (r = 0.190, p = 0.028). The percent change of RCF to L-NMMA was correlated to WLR (r = 0.197, r = 0.022).

Regression analysis revealed an independent relationship between WLR and both central PP (β = 0.277, p = 0.009) and percent change of RCF to L-NMMA (β = 0.170, p = 0.046).

Conclusion: Thus, central PP is an independent determinant of remodelling in small retinal arterioles indicating a coupling between the micro- and macrovascular changes to hypertension.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
146 - 146
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.024How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - C. Ott
AU  - U. Raff
AU  - J. Harazny
AU  - G. Michelson
AU  - R.E. Schmieder
PY  - 2012
DA  - 2012/11/17
TI  - 3.6 CENTRAL PULSE PRESSURE IS AN INDEPENDENT DETERMINANT OF VASCULAR REMODELLING IN THE RETINAL CIRCULATION
JO  - Artery Research
SP  - 146
EP  - 146
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.024
DO  - 10.1016/j.artres.2012.09.024
ID  - Ott2012
ER  -