Aim: To investigate association of central aortic pressure (CAP) parameters – augmentation index (AIx), augmentation index, normalized for heart rate 75/min (AIx75), augmentation pressure (AP), central systolic (SPa) and pulse pressure (PPa) with some clinical, laboratory and hemodynamic characteristics of patients with hypertension.

Material-Methods: 100 hypertensive patients at the age of 22–73 years (mean age 54±10,8) were examined, 43% men. Investigation included electrocardiography, echocardiography, determination of serum lipids, creatinine, creatinine clearance (CrCl) calculation, CAP registration using SphygmoCor device.

Results: AIx, AIx75, AP, PPa in women were higher than in men (30% vs. 20%; 28% vs. 17%; 14,5 vs. 8,7mmHg (p<0,001); 46,7 vs. 40,6mmHg (p<0,05); respectively), increased with older age (r=0,28; r=0,23; r=0,36; r=0,33 respectively; p<0,05), negatively correlated with CrCl (r=−0,55; r=−0,56; r=−0,53; r=−0,34 respectively; p<0,05). AIx, AIx75, AP negatively correlated with height and waist circumference (r=−0,48; r=−0,61; r=−0,41 and r=−0,32; r=−0,36; r=−0,21 respectively; p<0,05), positively - with LDL cholesterol (r=0,22; r=0,22; r=0,24 respectively; p<0,05). AIx, AIx75, AP, SPa correlated positively with late ventricular filling velocity (r=0,23; r=0,29; r=0,26; r=0,27 respectively; p<0,05). SPa correlated positively with myocardial mass (r=0,24; p<0,05), inter-ventricular septum and posterior wall thickness (r=0,36 and r=0,34 respectively; p<0,05), negatively – with ratio between early and late ventricular filling velocity (r=−0,28; p<0,05). AIx and AIx75 negatively correlated with diameter of left atrium and end-diastolic diameter of left ventricle (LV) (r=−0,23; r=−0,28 and r=−0,2; r=−0,29 respectively; p<0,05).

Conclusions: As a result, parameters of CAP were associated with gender, age, anthropometric characteristics, renal disease, dyslipoproteinemia, LV hypertrophy and diastolic dysfunction.