Artery Research

Volume 6, Issue 4, December 2012, Pages 156 - 156

P1.17 ARTERIAL STIFFNESS PARAMETERS AND AMBULATORY BLOOD PRESSURE MONITORING IN PATIENTS WITH HYPERTENSION

Authors
T.R. Bregvadze, V.J. Tseluyko, N.E. Mishchuk
Kharkiv Medical Academy of Postgraduate Education, Kharkov, Ukraine
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.054How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Aim: To investigate correlation between ambulatory blood pressure monitoring (ABPM) parameters and central aortic pressure (CAP) parameters (which are the main indicators of arterial stiffness), such as: augmentation index (AIx); augmentation index, normalized for heart rate 75/min (AIx75); augmentation pressure (AP); central systolic (SPa) and pulse pressure (PPa) in patients with hypertension.

Material-Methods: 100 hypertensive patients at the age of 22–73 years (mean age 54±10,8) were examined, 57% women. Investigation included electrocardiography, echocardiography, ABPM, determination of serum lipids and creatinine. CAP was measured with applanation tonometry of radial artery using SphygmoCor device.

Results: Mean levels of AP, SPa, PPa positively correlated with 24h systolic BP (SBP) (r=0,23; r=0,63; r=0,5 respectively; p<0,05), 24h PP (r=0,35; r=0,52; r=0,66 respectively; p<0,05), daytime and nighttime SBP (r=0,21; r=0,67; r=0,5 and r=0,19; r=0,5; r=0,44 respectively; p<0,05), high BP load (HIdx) and area under curve (HIpt) of SBP (r=0,19; r=0,6; r=0,47 and r=0,23; r=0,61; r=0,48 respectively; p<0,05). AIx, AP, PPa negatively correlated with heart rate (HR) (r=−0,22, p<0,05). AIx, AIx75, AP, SPa correlated positively with the diurnal variability (SD) of SBP (r=0,19; r=0,24; r=0,25; r=0,31 respectively; p<0,05). SPa had positive correlation with 24h diastolic BP (DBP) (r=0,44; p<0,05), daytime and nighttime DBP (r=0,48 and r=0,37 respectively; p<0,05), HIdx and HIpt of DBP (r=0,42 and r=0,45 respectively; p<0,05), SD of DBP (r=0,24; p<0,05).

Conclusions: According to our study results, parameters of CAP positively correlates with all parameters of ABPM, except HR. Arterial wall stiffness increases in response to lower HR and/or higher BP during 24h.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
156 - 156
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.054How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - T.R. Bregvadze
AU  - V.J. Tseluyko
AU  - N.E. Mishchuk
PY  - 2012
DA  - 2012/11/17
TI  - P1.17 ARTERIAL STIFFNESS PARAMETERS AND AMBULATORY BLOOD PRESSURE MONITORING IN PATIENTS WITH HYPERTENSION
JO  - Artery Research
SP  - 156
EP  - 156
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.054
DO  - 10.1016/j.artres.2012.09.054
ID  - Bregvadze2012
ER  -