Artery Research

Volume 6, Issue 4, December 2012, Pages 162 - 162

P1.41 THE CYP2J2 G-50T POLYMORPHISM AND MYOCARDIAL INFARCTION IN PATIENTS WITH CARDIOVASCULAR RISK PROFILE

Authors
R. Tzveova1, 2, G. Naydenova3, M. Tzekova3, R. Kaneva1, 2, V. Mitev1, 2
1Molecular Medicine Centre, Medical University, Sofia, Bulgaria
2Departments of Medical Chemistry and Biochemistry, Medical University, Sofia, Bulgaria
3Second Department of Cardiology, UMBAL "Dr. G. Stranski", Pleven, Bulgaria
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.078How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

CYP2J2 is responsible for the production of 5, 6, 8, 9, 11, 12, 14 and 15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. It is abundantly expressed in human heart and also present in kidney and vasculature. Carriers of a common polymorphism, the CYP2J2 -50G>T, have reduced expression of CYP2J2 mRNA in the heart.

We conducted a population-based, case-control study to determine whether common genetic variation in CYP2J2 gene was associated with the risk of acute myocardial infarction (AMI).

We analyzed 101 patients with AMI and 377 controls for a potential correlation of the CYP2J2 polymorphism G-50T with a history of myocardial infarction. To evaluate the genotypes of the samples real time PCR with predesigned TaqMan SNP Genotyping Assays (Applied Biosystem) was used.

The allelic frequencies of CYP2J2*1 and CYP2J2*7 variants were 0.90 and 0.10 in the control group and 0.84 and 0.16 in the affected group, respectively.

Comparison of genotype and allele frequencies between patients and controls in the study of promoter located SNP CYP2J2*7 did not provide a statistically significant association with AMI.

Our study found no association of the polymorphism in CYP2J2 with the development of AMI.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
162 - 162
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.078How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - R. Tzveova
AU  - G. Naydenova
AU  - M. Tzekova
AU  - R. Kaneva
AU  - V. Mitev
PY  - 2012
DA  - 2012/11/17
TI  - P1.41 THE CYP2J2 G-50T POLYMORPHISM AND MYOCARDIAL INFARCTION IN PATIENTS WITH CARDIOVASCULAR RISK PROFILE
JO  - Artery Research
SP  - 162
EP  - 162
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.078
DO  - 10.1016/j.artres.2012.09.078
ID  - Tzveova2012
ER  -