Artery Research

Volume 6, Issue 4, December 2012, Pages 162 - 162

P1.40 ASCENDING AORTIC DILATATION, ARTERIAL STIFFNESS AND CARDIAC ORGAN DAMAGE IN ESSENTIAL HYPERTENSION

Authors
F. Tosello, A. Milan, G. Bruno, I. Losano, M. Chiarlo, F. Veglio
University of Turin, Turin, Italy
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.077How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objectives of this study were to evaluate the prevalence of proximal ascending aortic dilatation (pAAD) in essential hypertensives and the association between pAA ectasia, arterial stiffness and cardiac organ damage.

Background: There are few data in literature concerning pAAD in arterial hypertension. It is not known whether pAAD may be related to increased cardiac organ damage and what the relation with central hemodynamics and arterial stiffness would be in essential hypertension.

Methods: We measured in 345 treated and untreated essential hypertensives (54.3±11 years) clinic blood pressures, central hemodynamics through radial tonometry and proximal aortic diameters using transthoracic echocardiography. BSA-normalized diameter cut off for aortic ectasia definition was 2,1 cm/m2.

Results: Overall prevalence of pAA dilatation was 17% in our population. We observed a slightly increase of central systolic (129.81±15.4 vs. 125.02±14.7 p 0.02) and pulse pressure (45.02±10.4 vs. 42±9.54; p 0.02) in patients with pAAD, whereas peripheral haemodynamic parameters were similar. Pulse wave velocity was significantly greater (9.26±2.33 vs. 7.70±1.69 p<0.0001), as well as the augmentation index (25.86±10.2 vs. 19.41±9.52; p<0.0001) in patients with pAAD, and this difference maintained after correction for age. Left ventricular hypertrophy was thrice as frequent (32.8% vs. 13.4% p<0.0001) compared to hypertensive patients without pAA dilatation.

Conclusions: This study shows a high prevalence (17%) of ascending aorta dilatation in patients affected by essential hypertension, without further complications. Dilatation of the ascending aorta is associated to increased cardiac organ damage and arterial stiffness.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
162 - 162
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.077How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - F. Tosello
AU  - A. Milan
AU  - G. Bruno
AU  - I. Losano
AU  - M. Chiarlo
AU  - F. Veglio
PY  - 2012
DA  - 2012/11/17
TI  - P1.40 ASCENDING AORTIC DILATATION, ARTERIAL STIFFNESS AND CARDIAC ORGAN DAMAGE IN ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - 162
EP  - 162
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.077
DO  - 10.1016/j.artres.2012.09.077
ID  - Tosello2012
ER  -