Artery Research

Volume 6, Issue 4, December 2012, Pages 161 - 162

P1.39 LOW SHEAR STRESS INDUCES PROGRESSION OF INTIMAL HYPERPLASIA AFTER CAROTID ENDARTERECTOMY

Authors
O. Tereshina, E. Surkova
Samara Medical State University, Samara, Russian Federation
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.076How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: The progression of intimal hyperplasia after carotid endarterectomy (CEA) is influenced by local hemodynamic factors. In our study we investigated associations between flow volume, velocity, shear stress and the intimal hyperplasia (IH) of the common carotid artery after CAE.

Methods: 1009 patients (60±15 years, 86% of which were male) who had had CEA between 2001 and 2011 were included in our study. Blood velocity, internal diameter, flow volume and intima-media thickness were measured using standardized duplex ultrasound examination at 3, 6, 9 and 12 months after operation. Shear stress was calculated as blood viscosity multiplied by blood velocity divided by internal diameter.

Results: The maximum progression of IH was observed at 3 months (1,4±0,4 mm). Afterwards progression IH decreased and stabilized at 12 months. Mean shear stress at bifurcation after CEA was 16,6±2,3 dynes/cm2 and was inversely related to internal diameter of common carotid artery at reconstruction site. Low mean shear stress correlated with low flow volume (r=0,56 P<0.0001). IH was inversely associated with shear stress (r=0,37 P<0.0001) and flow volume (r=0,35 P<0.0001).

Conclusions: This study demonstrates that low shear stress could lead to progression of IH after CEA. Strong correlation between flow volume and shear stress supports the conclusion that reduced flow volume can cause intimal hyperplasia. Artificial increase in artery’s diameter, especially with patch, leads to the development of intimal hyperplasia through decrease of shear stress.

Journal
Artery Research
Volume-Issue
6 - 4
Pages
161 - 162
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.076How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - O. Tereshina
AU  - E. Surkova
PY  - 2012
DA  - 2012/11/17
TI  - P1.39 LOW SHEAR STRESS INDUCES PROGRESSION OF INTIMAL HYPERPLASIA AFTER CAROTID ENDARTERECTOMY
JO  - Artery Research
SP  - 161
EP  - 162
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.076
DO  - 10.1016/j.artres.2012.09.076
ID  - Tereshina2012
ER  -