P4.23 HYPOECHGENIC CAROTID PLAQUES ARE MORE MOBILE IN COMPARISON WITH HYPERECHOGENIC ONES
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- 10.1016/j.artres.2012.09.171How to use a DOI?
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Background: Speckle Tracking Technology allows to assess multi-dimensional regional mechanics of carotid wall and carotid plaques. We hypothesized that hypoechogenic plaques are more mobile in comparison with hyperechogenic ones.
Objective: The objective of this study was to investigate the mechanical properties of carotid plaques using ultrasound speckle tracking.
Methods: Study population consisted of 43 patients with carotid atherosclerosis (aged 53–89, median-69). In total, 48 carotid plaques were analyzed. For each plaque, maximal circumferential strain (S) and strain rate (SR) were measured (in several points separately for plaque cap, core and base). According to grey scale median analysis all plaques were divided into hyperechogenic and low- and moderately echogenic ones. Degree of stenosis and plaque length were also assessed.
Results: S and SR were higher for all parts of hypo- and moderately echogenic plaques in comparison with hyperechogenic ones and for cap and core the difference was significant (table 1). Spearmen correlation analysis revealed significant negative associations between echogenicity and S and SR values (table 2). Multivariate linear regression confirmed that echogenicity is an independent determinant of S and SR after adjusting for potential confounders (degree of stenosis, plaque length). Univariant analysis found significant negative association between degree of stenosis and S and SR values (table 2).
| Hypo- and moderately echogenic plaques | Hyper-echogenic plaques | p | |
|---|---|---|---|
| cap | |||
| S | 5.42±3,71 | 3.78±2.25 | p=0.0006 |
| SR | 0.52±0.31 | 0.43±0.27 | p=0.02 |
| core | |||
| S | 6.3±3.55 | 4.22±2.60 | p=0.0003 |
| SR | 0.59±0.28 | 0.46±0.25 | p=0.008 |
| base | |||
| S | 4.78±3.2 | 3.61±3.14 | p=0.034 |
| SR | 0.47±0.27 | 0.42±0.37 | p=0.32 |
Data are expressed as mean ± SD
S and SR values of hypo- and moderately echogenic and hyperechogenic carotid plaques.
| Echogenicity (Spearmen correlation analysis) r* | Degree of Stenosis (Univariant analysis) r | |
|---|---|---|
| cap | ||
| S | −0.24 p=0.00045 | −0.12 p=0.049 |
| SR | −0.13 p=0.029 | −0.17 p=0.004 |
| core | ||
| S | −0.29 p=0.0004 | −0.07 p=0.39 |
| SR | −0.21 p=0.001 | −0.20 p=0.15 |
| base | ||
| S | −0.24 p=0.0043 | −0.14 p=0.086 |
| SR | −0.18 p=0.035 | −0.22 p=0.008 |
negative correlation implies that hypo- and moderate echogenic plaques have lower S and SR values
Associations between carotid plaque mobility (S and SR values), echogenicity and degree of stenosis.
Conclusion: Hypo-and moderately echogenic carotid plaques are more mobile in comparison with hyperechogenic ones. Degree of stenosis is negatively associated with increased mobility and this may explain the fact that many vulnerable, symptomatic plaques have relatively moderate degree of stenosis.
Cite this article
TY - JOUR AU - E.N. Borskaya AU - O.B. Kerbikov AU - R.V. Panteleev AU - E.B. Shakhnovich AU - N.A. Doinichenko AU - T.V. Krutova AU - A.V. Averyanov PY - 2012 DA - 2012/11/17 TI - P4.23 HYPOECHGENIC CAROTID PLAQUES ARE MORE MOBILE IN COMPARISON WITH HYPERECHOGENIC ONES JO - Artery Research SP - 189 EP - 190 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.171 DO - 10.1016/j.artres.2012.09.171 ID - Borskaya2012 ER -