P4.24 COMPLIANCE AND DISTENSIBILITY OF DIFFERENT SEGMENTS OF AORTA AND RELATIONSHIPS BETWEEN AORTA DISTENSIBILITY AND SYSTOLIC AND DIASTOLIC FUNCTIONS OF THE LEFT VENTRICULAR
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- 10.1016/j.artres.2012.09.172How to use a DOI?
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Objective: to investigate compliance and distensibility of different segments of aorta and to assess the influence of systolic and diastolic function on distensibility.
Methods: Study population consisted of 33 healthy subjects (aged 16–26, median-18). Compliance and Distensibility were calculated using M-mode ultrasound measurements at five locations: the sinuses of Valsalva, the proximal ascending aorta, the aortic arch, the infrarenal aorta, the abdominal aorta before bifurcation and also in the left common carotid artery (CCA) using wall-tracking software. All subjects underwent comprehensive transthoracic echocardiography and Central_BP measurement. Left ventricular peak wall stress (LVPS) was calculated as follows: LVPS=0.86x (0.334xSAPxEDD)/ [PWTdx(1+(PWTd/EDD))]-2, where SAP- systolic blood pressure, PWTd- end-diastolic posterior-lateral wall thickness, EDD- end-diastolic diameter.
Results: Compliance gradually decreased from the proximal to the distal segments of aorta (table 1), whereas distensibility coefficient (DC) and β-stiffness index did not significantly differ in various aorta segments. By univariant analysis negative direct associations were found between DC and LVPS (r=−0,48 p=0,005 for DC in proximal ascending aorta). This relation was tested by multivariate linear regression after adjusting for potential confounders (age, male sex, weight). The model demonstrated that LVPS and E/A ratio are the only independent determinant of aorta distensibility (β=−0.41 and −0.43 for LVPS and E/A accordingly p<0.03, DC in the proximal ascending aorta).
| Compliance C=ΔD/(SBP-DBP) mm × mm Hg−1 | Distensibility Coeffieicient DC= 2×ΔD/[Ddx(SBP-DBP)] mm Hg−1 | Stiffness index β=[ln(SBP/DBP)×Dd]/ ΔD | Strain CS=ΔD/D d × 100% | |
|---|---|---|---|---|
| Sinuses of Valsalve | 0.16±0.1 | 0.015±0.009 | 2.62±2.17 | 21±7 |
| Proximal Ascending Aorta | 0.13±0.09 | 0.012±0.008 | 2.88±2.08 | 17±7 |
| Aortic Arch | 0.11±0.08 * | 0.013±0.008 | 2.53±1.32 | 20±8 |
| Infrarenal Aorta | 0.09±0.04 *,** | 0.015±0.007 | 2.34±1.2 | 23±5 |
| Abdominal Aorta before Bifurcation | 0.08±0.04 *,** | 0.015±0.009 | 2.43±0.92 | 21±5 |
| left CCA | 0.016±0.005 *** | 0.005±0.002 *** | 6.51±3.94 *** | 7.7±2 *** |
Data are expressed as mean ± SD,
significant difference (p<0.05) with Sinuses of Valsalve,
-significant difference (p<0.05) with Proximal Ascending Aorta,
- significant difference between CCA and all aorta segments, ΔD = Ds-Dd, where Ds and Dd – systolic and diastolic diameters, SBP and DBP – central systolic and diastolic blood pressure.
Compliance, Distensibility and Stiffness in the Different Aorta Segments and in the left CCA
Conclusions: Compliance gradually decreased from the proximal to the distal aorta segments (from the sinuses of Valsalva to the bifurcation of abdominal aorta) whereas stiffness does not differ significantly. Both systolic and diastolic parameters of left ventricular influence the distensibility.
Cite this article
TY - JOUR AU - E.N. Borskaya AU - O.B. Kerbikov AU - I.V. Kaloshina AU - R.V. Panteleev AU - I.M. Kostin AU - N.A. Doinichenko AU - T.V. Krutova AU - A.V. Averyanov PY - 2012 DA - 2012/11/17 TI - P4.24 COMPLIANCE AND DISTENSIBILITY OF DIFFERENT SEGMENTS OF AORTA AND RELATIONSHIPS BETWEEN AORTA DISTENSIBILITY AND SYSTOLIC AND DIASTOLIC FUNCTIONS OF THE LEFT VENTRICULAR JO - Artery Research SP - 190 EP - 190 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.172 DO - 10.1016/j.artres.2012.09.172 ID - Borskaya2012 ER -