Artery Research

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Volume 6, Issue 2, June 2012, Pages 71 - 77

Vascular characteristics in patients with resistant hypertension and type-II-diabetes mellitus

Authors
Trine Koustrup Soendera, *, Jacob Eifer Møllerb, Brian Bridal Løgstrupc, Jess Lambrechtsend, Jørgen Hangaarde, Kenneth Egstrupa
aDepartment of Medical Research, University Hospital of Odense, Svendborg Hospital, Svendborg, Denmark
bDepartment of Cardiology, University Hospital of Copenhagen Rigshospitalet, Copenhagen, Denmark
cDepartment of Internal Medicine, Center of Excellence, Silkeborg Hospital, Denmark
dDepartment of Cardiology, University Hospital of Odense, Svendborg Hospital, Svendborg, Denmark
eDepartment of Endocrinology, University Hospital of Odense, Svendborg Hospital, Svendborg, Denmark
*Corresponding author. E-mail address: trine@tom-trine.dk (T.K. Soender).
Corresponding Author
Trine Koustrup Soender
Received 29 September 2011, Revised 17 February 2012, Accepted 28 February 2012, Available Online 20 March 2012.
DOI
10.1016/j.artres.2012.02.002How to use a DOI?
Keywords
Arterial stiffness; Pulse wave velocity; Total arterial resistance; Total arterial compliance; Resistant hypertension; Type-II-diabetes
Abstract

Background: Resistant hypertension is presumed to be common in patients with type-II-diabetes mellitus (type-II-DM) and arterial stiffness has been proposed to play a major role in the development hereof. Our objective with this study was to examine differences in vascular characteristics in patients with controlled (CH), uncontrolled (UH) and resistant hypertension (RH) and type-II-DM and to assess whether increased arterial stiffness could explain the prevalence of resistant hypertension.

Methods and results: Vascular characteristics were examined using ambulatory blood pressure measurements, applanation tonometry and cardiac ultrasound. We estimated carotid-to-femoral pulse wave velocity using Sphygmocor. Characteristic impedance, arterial resistance, arterial compliance and augmentation index was estimated from analysis of pressure- and flow-curves. Finally ambulatory arterial stiffness index was estimated using ambulatory blood pressure measurements. We included 114 patients in the study of whom 39 had RH. When compared to patients with CH, patients with RH had increased pulse wave velocity (10.8 m/s [8.78; 12.23] versus 8.55 m/s [7.55; 10.6], P = 0.002) and reduced total arterial compliance (0.81 ml/mmHg [0.55; 0.95] versus 0.93 ml/mmHg [0.68; 1.36], P = 0.03) however differences were non-significant when adjusted for blood pressure (P = 0.2 and P = 0.2) Following statistical adjustment patients with UH had increased total arterial resistance though as compared to patients with CH (1.63 mmHg/ml*s−1 [1.37; 1.92] versus 1.38 mmHg/ml*s−1 [1.2; 1.71]) (P = 0.03).

Conclusion: In the present study patients with RH and type-II-DM do not have increased intrinsic arterial stiffness when compared to patients with CH, thus we conclude that increased intrinsic arterial stiffness is not the cause of resistant hypertension in the present study.

Copyright
© 2012 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
6 - 2
Pages
71 - 77
Publication Date
2012/03/20
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.02.002How to use a DOI?
Copyright
© 2012 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Trine Koustrup Soender
AU  - Jacob Eifer Møller
AU  - Brian Bridal Løgstrup
AU  - Jess Lambrechtsen
AU  - Jørgen Hangaard
AU  - Kenneth Egstrup
PY  - 2012
DA  - 2012/03/20
TI  - Vascular characteristics in patients with resistant hypertension and type-II-diabetes mellitus
JO  - Artery Research
SP  - 71
EP  - 77
VL  - 6
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.02.002
DO  - 10.1016/j.artres.2012.02.002
ID  - Soender2012
ER  -