Artery Research

Volume 24, Issue C, December 2018, Pages 82 - 82

P11 EFFECT OF AGING ON THE PRESSURE ASYMPTOTE AND TIME CONSTANT OF EXPONENTIAL DIASTOLIC AORTIC PRESSURE DECAY IN HUMANS

Authors
Tetsu Yamakado
Suzuka University of Medical Science, Suzuka, Japan
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.064How to use a DOI?
Abstract

There are few data regarding the effect of aging on pressure asymptote (Pasymptote) and time constant (Tau) of exponential diastolic aortic pressure (AoP) decay in normal human heart. To investigate this issue, we analyzed high-fidelity AoP, measured by use of a catheter-tipped manometer in 71 normal subjects who underwent diagnostic cardiac catheterization but who were found to have normal coronary artery and LV function. Subjects who had hypertension, diabetes or renal disease were excluded. There were 49 men and 22 women, ranging in age from 20 to 80 years. We analyzed diastolic AoP sampled every 5 ms from the point of minimal dP/dt to the top of ECG-R waves of the next beat, and estimated Tau and Pasymptote by the exponential best fitting with a variable Pasymptote results. Systolic AoP were significantly increased with age, but mean and diastolic AoP remained unchanged. Pasymptote was 58.5 ± 8.1 mmHg and Tau was 436 ± 105 msec. Pasymptote show no significant age-related change, but strongly and positively correlated with systolic, diastolic and mean AoP (R2 = 0.39, 0.70 and 0.66, respectively). For Tau, it was weakly and positively related with both age and AoP (Age: R2 = 0.20, AoP: R2 = 0.08–0.20).

Conclusion: We documented Pasymptote and Tau of the Windkessel with the beating heart in normal humans. Tau was associated with aging, whereas Pasymptote, which increased with the level of AoP, did not vary with aging per se, at least until the ninth decade. These data may provide insight into the understanding of AoP physiology.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
82 - 82
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.064How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Tetsu Yamakado
PY  - 2018
DA  - 2018/12/04
TI  - P11 EFFECT OF AGING ON THE PRESSURE ASYMPTOTE AND TIME CONSTANT OF EXPONENTIAL DIASTOLIC AORTIC PRESSURE DECAY IN HUMANS
JO  - Artery Research
SP  - 82
EP  - 82
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.064
DO  - 10.1016/j.artres.2018.10.064
ID  - Yamakado2018
ER  -