Artery Research

Volume 24, Issue C, December 2018
Research Article

1. A numerical study on the application of the functionally graded bioabsorbable materials in the stent design

Hossein Bahreinizad, Milad Salimi Bani, Arezoo Khosravi, Alireza Karimi
Pages: 1 - 8
Background: Angioplasty with stenting is one of the primary treatment for coronary artery disease, hence, performance of the stent is deemed important. Bioabsorbable stents are the new generation of stents. Bioabsorbable magnesium alloys are a promising solution for adverse effects of long-term usage...
Research Article

2. Arterial baroreflex sensitivity: Relationship with peripheral chemoreflex in patients with chronic heart failure

Nikita Trembach, Igor Zabolotskikh
Pages: 9 - 15
Background: The purpose of this study was to evaluate the relationship between the breath-holding duration and the sensitivity of the arterial baroreflex, as well as the prognostic value of the breath-holding test in the assessment of decreased baroreflex sensitivity (BRS) in patients with chronic heart...
Research Article

3. Peripheral blood flow regulation in response to sympathetic stimulation in individuals with down syndrome

Thessa I.M. Hilgenkamp, Sang Ouk Wee, Elizabeth C. Schroeder, Tracy Baynard, Bo Fernhall
Pages: 16 - 21
Background: Individuals with Down syndrome (DS) experience autonomic dysfunction, with reduced sympathetic and parasympathetic control. This results in alterations in resting heart rate and blood pressure and attenuated responses to sympathoexcitatory stimuli. It is unknown to what extent this impacts...
Research Article

4. Combinatorial effect of lower extremity blood flow restriction and low intensity endurance exercise on aorta of old male rats: Histomorphological and molecular approach

Mohammad-Abbas Bejeshk, Siyavash Joukar, Beydolah Shahouzehi, Majid Asadi-shekari, Mohammadamin Rajizadeh, Alireza Raji-amirhasani, Vida Naderi-boldaji
Pages: 22 - 31
Objective: Given the importance of knowing the effects of blood flow restriction (BFR) plus exercise training (BFR training) on the cardiovascular system, present study conducted to determine the effect of combination of BFR with low intensity endurance exercise on aorta of old rats. Methods: Animal...
Research Article

5. Association of serum paraoxonase activity with lipid profile, APO-A and APO-B in subjects with different levels of HDL

Maryam Teimouri, Hashem Nayeri
Pages: 32 - 39
Background: Coronary heart diseases are inversely related to plasma high-density lipoprotein (HDL) level. Paraoxonase-1 (PON1) is mainly associated with HDL and plays a vital role in protection of low-density lipoprotein (LDL) and HDL. The aim of this study was to investigate the association between...
Research Article

6. Relationships between blood pressure variability and silent cerebral infarction in patients with primary hypertension

Xianglin Chi, Xingyao Wang, Zhaorong Guo, Honghao Man, Hongxiao Xu, Yingcui Wang, Chengyu Liu
Pages: 40 - 46
Aims: This study aimed to investigate the relationship between blood pressure variability and the incidence of silent cerebral infarction (SCI) in patients with primary hypertension. Methods: The 346 hospitalized patients with primary hypertension were divided into primary hypertension group (160 cases)...
Research Article

7. Interaction of the blood components and plaque in a stenotic coronary artery

Alireza Karimi, Reza Razaghi
Pages: 47 - 61
Background: So far, in the stress calculation of the plaques, the blood has been simulated as a single component, and the role of the mechanical interaction between the red blood cells (RBCs), white blood cells (WBCs), and plasma with that of the plaque has been neglected. This study was aimed at proposing...
Conference Abstract

8. PERIPHERAL BLOOD FLOW REGULATION IN RESPONSE TO SYMPATHETIC STIMULATION IN INDIVIDUALS WITH DOWN SYNDROME

Thessa I.M. Hilgenkamp, Sang Ouk Wee, Tracy Baynard, Bo Fernhall
Pages: 62 - 62
Background: Individuals with Down syndrome (DS) experience autonomic dysfunction, with reduced sympathetic and parasympathetic control. This results in alterations in resting heart rate and blood pressure and attenuated responses to sympathoexcitatory stimuli. It is unknown to what extent this impacts...
Conference Abstract

9. VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS

Negoita Madalina, Manisty Charlotte, Bhuva Anish, Hughes Alun, Parker Kim, Khir Ashraf
Pages: 62 - 62
Background: Pulse Wave Velocity (PWV) is a measure of arterial stiffness which predicts cardiovascular risk independently of blood pressure. Local PWV can be measured non-invasively in the ascending aorta of adults by means of Ultrasound (US), using successive recordings of Diameter (D) and the velocity...
Conference Abstract

10. THE REGULATORY ROLE OF COAGULATION FACTORS ON ARTERIAL FUNCTION

Jeremy Lagrange
Pages: 63 - 63
The coagulation takes place in the physiological system of hemostasis. Hemostasis is known to be disturbed in many diseases leading to hemorrhages or thrombosis. Despite the role of coagulation in hemostasis, recent evidence suggest that coagulation factors are involved in other physiological as well...
Conference Abstract

11. NEW DRUG TARGETS FOR SLOWING VASCULAR AGEING: SIRT1, SIRT5, JUND AND P66SCH

Luca Liberale
Pages: 63 - 63
Western societies are aging due to an increasing life span, decreased birth rates, and improving social and health conditions. On the other hand, the prevalence of cardiovascular (CV) and cerebrovascular (CBV) diseases rises with age. Thus, in view of the ongoing aging pandemic, it is appropriate to...
Conference Abstract

12. GREATER AORTIC STIFFNESS IS ASSOCIATED WITH LOWER HIPPOCAMPAL CEREBROVASCULAR RESERVE BUT NOT CEREBRAL BLOOD FLOW OR AMYLOID IN MIDDLE-AGED AND OLDER ADULTS

Lyndsey E. DuBose, Laura L. Boles Ponto, David J. Moser, Gary L. Pierce
Pages: 63 - 63
Background: Recent studies suggests cerebrovascular dysfunction precedes amyloid deposition and cognitive impairment in Alzheimer’s disease (AD). However, if functional impairments in the hippocampus, as evidenced by reduced hippocampal cerebral blood flow (CBF) during memory stimulation and cerebrovascular...
Conference Abstract

13. ASSOCIATION OF PULSE WAVE VELOCITY AND BODY MASS INDEX IN HEALTHY MEXICAN POPULATION

Daniela Avila Novoa, M. Cárdenas, E.G. Cardona, D. Cardona, F. Grover, C. Ramos, J. Trujillo
Pages: 64 - 64
Rational: Cardiovascular diseases represent the main cause of morbidity and mortality throughout the world (1). Arterial stiffness has shown to be an important predictor of cardiovascular events, and pulse wave velocity (PWV) is a marker of subclinical organ damage which can be measured by different...
Conference Abstract

14. WHICH IS MORE CORRELATED WITH HYPERTENSIVE ORGAN DAMAGE, SLEEP BLOOD PRESSURE ASSESSED BY SELF-MEASURED AT HOME OR AMBULATORY BLOOD PRESSURE MONITORING?: THE JAPAN MORNING SURGE-HOME BLOOD PRESSURE (J-HOP) STUDY

Sirisawat Wanthong, Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario
Pages: 64 - 64
Objective: To assess the associations with hypertensive target organ damage (TOD) of sleep SBP assessed by self-measured home blood pressure monitoring (HBPM) and ambulatory blood pressure monitoring (ABPM). Methods: Data of 1008 participants in the J-HOP study who measured sleep BP using both HBPM,...
Conference Abstract

15. MOLECULAR AND CELLULAR CHANGES IN ARTERIAL FUNCTION OVER THE LIFE COURSE – FROM ACCELERATED AGEING TO CALCIFICATION

Catherine M. Shanahan
Pages: 64 - 64
Vascular stiffening and calcification are hallmarks of ageing and these pathologies are accelerated in patients with diabetes and renal failure. Emerging evidence has defined a role for nuclear lamina defects and the DNA damage response in driving vascular calcification. The mechanisms responsible are...
Conference Abstract

16. NOVEL RESEARCH FUNDING OPPORTUNITIES

Warwick Anderson
Pages: 64 - 65
It is a fortunate paradox that research motivated simply by a wish to better understand the natural world can later result in the most powerful applications imaginable. By definition, the outcome of any research is unknown until the research is finished. The outcomes are even less predictable at the...
Conference Abstract

17. ARTERIAL STIFFNESS AS A RISK FACTOR FOR CEREBRAL VASCULAR LESIONS

Dariusz Gasecki
Pages: 65 - 65
Increased arterial stiffness, a biomarker of vascular aging, is a recognized subclinical organ damage, and may thus serve as predictor of cardiovascular disease. The predictive value of arterial stiffness is higher in patients with higher baseline cardiovascular risk, such as in patients with hypertension....
Conference Abstract

18. CHILDHOOD DETERMINANTS OF ARTERIAL DYSFUNCTION CENTRAL AND PERIPHERAL BLOOD PRESSURE

Renate Oberhoffer
Pages: 65 - 65
Arterial Hypertension is one of the leading causes of death and disability worldwide. Measurement of peripheral brachial blood pressure using cuff sphygmomanometry belongs to the clinical routine assessment from childhood on. Based on age and length related reference values, it is widely accepted as...
Conference Abstract

19. ARE CENTRAL HEMODYNAMIC PARAMETERS BETTER PROGNOSTIC MARKERS THAN PERIPHERAL BLOOD PRESSURE IN STROKE?

Alberto Avolio, Ernesto L. Schiffrin
Pages: 65 - 65
The complex pathophysiological mechanisms involved in stroke confound the associative and causal role of blood pressure. This is particularly relevant in monitoring changes in blood pressure with respect to treatment efficacy and stroke outcome, which is highly dependent on the both patient and stroke...
Conference Abstract

20. THE HAEMODYNAMIC GENESIS OF HYPERTENSION

Phil Chowienczyk
Pages: 65 - 66
Hypertension has classically been attributed to an increase in peripheral vascular resistance. Such an increase in peripheral vascular resistance would increase mean and diastolic blood pressure but have little influence on pulse pressure. However, hypertension in our ageing society occurs mainly as...
Conference Abstract

21. 1.1 PROMOTION OF ARTERIAL STIFFNESS BY CHILDHOOD CANCER AND ITS CHARACTERISTICS IN ADULT LONG-TERM SURVIVORS

Natalie Arnold, Hiltrud Merzenich, Arthur Wingerter, Andreas Schluz, Astrid Schneider, Jürgen H. Prochaska, Sebastian Göbel, Marie-Astrid Neu, Nicole Henninger, Marina Panova-Noeva, Susan Eckerle, Claudia Spix, Irene Schidtmann, Karl J. Lackner, Manfred E. Beutel, Norbert Pfeiffer, Thomas Münzel, Jörg Faber, Philipp S. Wild
Pages: 67 - 67
Background: Vascular alterations induced by antineoplastic treatment might be considered as a possible underlying mechanism of increased cardiovascular (CV) sequelae in childhood cancer survivors (CCS). Therefore, we thought to evaluate the changes in arterial stiffness (AS) among long-term CCS compared...
Conference Abstract

22. 1.2 ASSOCIATIONS BETWEEN INDICATORS OF CARDIOVASCULAR DISEASE AND PULSE WAVE ANALYSIS AND VELOCITY: A COMPARISON OF DEVICES

Elizabeth Ellins, Lucy Lennon, Olia Papacosta, Goya Wannamethee, Peter Whincup, Julian Halcox
Pages: 67 - 67
Background: Both the Sphygmocor (S) and Vicorder (V) devices can be used for Pulse Wave Analysis (PWA) and Velocity (PWV). We investigated if there were differences in the associations between markers of Cardiovascular Disease (CVD) and PWA and PWV variables as assessed by the two devices. Methods:...
Conference Abstract

23. 1.3 PREDICTION OF CARDIOVASCULAR MORTALITY AND MORBIDITY IN THE MALMö DIET-CANCER COHORT FOR THE IDENTIFICATION OF HEALTHY VASCULAR AGEING, USING MARKERS OF VASCULAR STATUS

Benjamin Nilsson Wadström, Peter Nilsson, Abd Al-Hakim Fatehali, Gunnar Engstrom
Pages: 67 - 68
Background: This study aims to translate two arterial measurements, aortic Pulse Wave Velocity (aPWV) and carotid Intima-Media Thickness (cIMT), into a combined Vascular Ageing Index (VAI), to evaluate the predictive power of VAI and utilize it to identify a sub-group with Healthy Vascular Ageing (HVA). Methods:...
Conference Abstract

24. 1.4 PROGNOSTIC VALUE OF PROXIMAL AORTA LONGITUDINAL STRAIN IN MARFAN SYNDROME

Andrea Guala, Jose Rodríguez-Palomares, Aroa Ruiz-Muñoz, Minerva Gandara, Violeta Sanchez, Alberto Forteza, David Garcia-Dorado, Artur Evangelista, Gisela Teixido-Tura
Pages: 68 - 68
Background: Aortic root dilation and type A aortic dissection are the most common cardiovascular complications of Marfan syndrome (MFS). Current clinical management of MFS patients relies on a close follow-up of aortic root diameter and preventive aortic root surgery in case of severe or fast-progressing...
Conference Abstract

25. P68 THE HIDDEN PREDICTOR OF CARDIOVASCULAR OUTCOME

José Sousa, João Lopes, Liliana Reis, Marta Madeira, Carolina Lourenço, Lino Gonçalves
Pages: 68 - 68
Background: Hyperuricemia is common in patients with hypertension, diabetes and obesity. Whether it is an independent cardiovascular risk factor (CVRF) or not remains controversial. Purpose: To determine the prognostic value of uricemia in the setting of acute coronary syndrome (ACS). Methods: Retrospective...
Conference Abstract

26. 1.5 DEEP VASCULAR PHENOTYPING IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA

Rosa Maria Bruno, Louise Marais, Hakim Khettab, Aurélien Lorthioir, Xavier Jeunemaitre, Stèphane Laurent, Pierre Boutouyrie, Michel Azizi
Pages: 68 - 68
Background: Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease involving medium-sized muscular arteries, whose pathophysiology is still unknown. Objectives: We aimed at identifying systemic vascular alterations in usually non-affected arteries of patients with...
Conference Abstract

27. 1.6 AORTIC PULSE WAVE VELOCITY IN PORTUGUESE CHILDREN AND ADOLESCENTS – RESULTS FROM THE PORTUGUESE VASCULAR PHENOTYPE IN CHILDREN AND ADOLESCENTS (PORT-VASPH) COHORT

Telmo Pereira, João Maldonado, Margarida Carvalho
Pages: 68 - 69
Introduction: The PORT-VASPh Cohort was designed to contribute to a better understanding of vascular function in children and adolescents, mostly focusing PWV and other complementary aspects of arterial hemodynamics. Methods: The PORT-VASPh cohort is a prospective and observational study, with 953 children...
Conference Abstract

28. 2.1 KNOCK-OUT OF MATRIX METALLOPROTEINASE-12 EXACERBATES COMPROMISED MECHANICAL HOMEOSTASIS IN ARTERIAL AGING

Bart Spronck, Abhay B. Ramachandra, Jakub Toczek, Jinah Han, Mehran Sadeghi, Jay D. Humphrey
Pages: 69 - 69
Background: Matrix metalloproteinase-12 (MMP12) may modulate arterial stiffening with age [1]. We aimed to study the effect of aging on biaxial arterial stiffness in wild-type (WT) and MMP12 knock-out (MMP12-/-) mice. Methods and Results: After euthanasia, descending thoracic (DTA) and suprarenal abdominal...
Conference Abstract

29. 2.2 GREATER BLOOD PRESSURE VARIABILITY IS ASSOCIATED WITH LOWER COGNITIVE PERFORMANCE – THE MAASTRICHT STUDY

Tan Lai Zhou, Abraham Kroon, Coen Stehouwer, Martin van Boxtel, Frans Verhey, Miranda Schram, Thomas van Sloten, Ronald Henry
Pages: 69 - 70
An increasing number of individuals will face age-related cognitive difficulties, as life expectancy has increased globally. It is therefore important to identify modifiable risk factors for cognitive impairment. Very short- to mid-term blood pressure variability (BPV) may be such factor, as it may cause...
Conference Abstract

30. 2.3 OCCUPATIONAL, SPORT AND LEISURE RELATED PHYSICAL ACTIVITY HAVE CONTRASTING EFFECTS ON NEURAL BAROREFLEX SENSITIVITY. THE PARIS PROSPECTIVE STUDY III

Rachel Climie, Pierre Boutouyrie, Marie-Cecile Perier, Edouard Chaussade, Matthieu Plichart, Lucile Offredo, Catherine Guilbout, Thomas van Sloten, Frederique Thomas, Bruno Pannier, James Sharman, Stephane Laurent, Xavier Jouven, Jean-Philippe Empana
Pages: 70 - 70
Background: Physical activity (PA) is beneficial for baroreflex sensitivity (BRS), but it is unclear whether the type of PA has similar effects on the neural (nBRS) or vascular (carotid stiffness) components of BRS. We sought to determine this in healthy adults from a community- based study via assessment...
Conference Abstract

31. 2.4 CENTRAL SYSTOLIC BLOOD PRESSURE PROVIDES ADDITIONAL INFORMATION IN RISK PREDICTION IN HEMODIALYSIS PATIENTS

Christopher C. Mayer, Julia Matschkal, Pantelis A. Sarafidis, Stefan Hagmair, Georg Lorenz, Susanne Angermann, Matthias C. Braunisch, Marcus Baumann, Uwe Heemann, Christoph Schmaderer, Siegfried Wassertheurer
Pages: 70 - 70
Background: Association of Ambulatory Blood Pressure Monitoring (ABPM) with mortality depends on cardiac function in hemodialysis patients. Evidence for the predictive power of central Systolic Pressure (cSBP) is inconclusive. Thus, this study aimed to investigate the additional information of ambulatory...
Conference Abstract

32. 2.5 DOES WAVE REFLECTION PROTECT THE MICROVASCULATURE FROM HIGH PULSE PRESSURE?

Avinash Kondiboyina, Joe Smolich, Michael Cheung, Berend Westerhof, Nico Westerhof, Jonathan Mynard
Pages: 70 - 71
Background: Wave reflection (caused by a stiffness increase from large to small arteries) has been considered to protect against high microvasculature Pulse Pressures (mPP) (1). However, according to transmission line theory, Transmission (T) and Reflection (R) coefficients are proportional (T = 1+R),...
Conference Abstract

33. 2.6 FEASIBILITY OF AORTIC WAVE INTENSITY ANALYSIS FROM SEQUENTIALLY ACQUIRED CARDIAC MRI AND NON-INVASIVE CENTRAL BLOOD PRESSURE

Anish Bhuva, Niro Nadarajan, Andrew D’Silva, Camilla Torlasco, Redha Boubertakh, Siana Jones, Paul Scully, Rachel Bastiaenen, Guy Lloyd, Sanjay Sharma, James Moon, Kim Parker, Charlotte Manisty, Alun Hughes
Pages: 71 - 71
Background: Wave intensity analysis (WIA) in the aorta offers important clinical and mechanistic insights but is difficult non-invasively. We performed WIA by combining high temporal resolution cardiovascular magnetic resonance (CMR) flow velocity and non-invasive central blood pressure (BP) waveform...
Conference Abstract

34. 3.1 STRAIN DISCONTINUITIES IN CAROTID ATHEROSCLEROTIC PLAQUES – A NOVEL MARKER FOR PLAQUE VULNERABILITY?

Tim Vonk, Evelien Hermeling, Floris Schreuder, Werner Mess, Eline Kooi
Pages: 71 - 71
Objective: Rupture of atherosclerotic plaques is ultimately a biomechanical event. We aim to develop and validate a novel method using ultrasound radiofrequency (RF) measurements to determine intraplaque inhomogeneities in the strain distribution with a high axial resolution which may identify rupture-prone...
Conference Abstract

35. 2.7 FITNESS MODIFIES THE ASSOCIATION BETWEEN EXERCISE BLOOD PRESSURE AND LEFT-VENTRICULAR MASS IN ADOLESCENCE

Zhengzheng Huang, Ricardo Fonseca, James Sharman, Nish Chaturvedi, George Smith, Deborah Lawlor, Laura Howe, Chloe Park, Alun Hughes, Martin Schultz, Martin Schultz
Pages: 71 - 71
Objective: Exaggerated exercise blood pressure (BP) is associated with higher left-ventricular mass index (LVMI). Paradoxically, exercise BP and LVMI may be higher with greater fitness, but underlying factors are poorly understood. This study aimed to determine the influence of fitness on exercise BP...
Conference Abstract

36. 2.8 RELATIONSHIPS BETWEEN ADIPOSITY AND LEFT VENTRICULAR FUNCTION IN ADOLESCENTS: MEDIATION BY BLOOD PRESSURE AND OTHER CARDIOVASCULAR MEASURES

Hannah Taylor, Alun D. Hughes, Abigail Fraser, Laura Howe, George Davey Smith, Debbie Lawlor, Nishi Chaturvedi, Chloe Park
Pages: 71 - 72
Introduction: Increased adiposity is associated with poorer left ventricular (LV) function but the mediating role of blood pressure (BP) and other cardiovascular measures is unknown. We investigated the roles of potential mediators in adolescents in a UK birth cohort, the Avon Longitudinal Study of Parents...
Conference Abstract

37. 3.2 RESERVOIR PRESSURE INTEGRAL IS INDEPENDENTLY ASSOCIATED WITH THE REDUCTION IN RENAL FUNCTION IN AN OLDER POPULATION

Kunihiko Aizawa, Francesco Casanova, David M. Mawson, Kim M. Gooding, W. David Strain, Phillip E. Gates, Gerd Östling, Faisel Khan, Helen M. Colhoun, Carlo Palombo, Kim H. Parker, Jan Nilsson, Angela C. Shore, Alun D. Hughes
Pages: 72 - 73
Background: Central haemodynamic parameters derived from reservoir pressure analysis (RPA-parameters) exhibit prognostic utility. Alterations in reservoir function could have an unfavourable influence on target organs, such as the kidneys. We determined in older adults whether these RPA-parameters would...
Conference Abstract

38. 3.3 ROLE OF ARTERIAL STIFFNESS AND BLOOD PRESSURE VARIABILITY IN THE DEFINITION OF SHATS (SYSTEMIC HEMODYNAMIC ATHEROTHROMBOTIC SYNDROME)

Angelo Scuteri, Valentina Rovella, Danilo Alunni Fegatelli, Manfredi Tesauro, Marco Gabriele, Nicola Di Daniele
Pages: 73 - 73
Background: CV risk exponentially increases as the number of damaged organs increases The Systemic Hemodynamic Atherosclerotic Syndrome (SHATS) represents a novel conceptualization of the CV continuum focusing on simultaneous multi-organ alteration. This is the first study operationally defining SHATS...
Conference Abstract

39. 3.4 A CLINICAL SCORE TO PREDICT ELEVATED ARTERIAL STIFFNESS: DERIVATION AND VALIDATION IN 3,943 HYPERTENSIVE PATIENTS

Panagiotis Xaplanteris, Charalambos Vlachopoulos, Athanasios Protogerou, Konstantinos Aznaouridis, Dimitris Terentes-Printzios, Antonis Argyris, Nikolaos Tentolouris, Petros Sfikakis, Dimitris Tousoulis
Pages: 73 - 73
Purpose/Background/Objectives: Aortic stiffness assessed by carotid-femoral pulse wave velocity (PWV) is an important predictor to gauge the overall risk of hypertensive patients; nonetheless, it is underutilized in everyday practice. We derived a simple scoring system based on clinical variables that...
Conference Abstract

40. 3.5 CUFF BLOOD PRESSURE IS PROGRESSIVELY MORE BIASED WITH INCREASING AGE: INDIVIDUAL PARTICIPANT LEVEL ANALYSIS FROM THE INSPECT CONSORTIUM

Dean Picone, Martin Schultz, Petr Otahal, Ahmed Al-Jumaily, J. Andrew Black, Willem Bos, Chen-Huan Chen, Hao-Min Chen, Antoine Cremer, Nathan Dwyer, Ricardo Fonseca Diaz, Brian Gould, Alun Hughes, Hack-Lyoung Kim, Peter Lacy, Esben Laugesen, Sandy Muecke, Nobuyuki Ohte, Stefano Omboni, Christian Ott, Xiaoqing Peng, Telmo Pereira, Giacomo Pucci, Philip Roberts-Thomson, Niklas Rossen, Roland Schmieder, Velandai Srikanth, Ralph Stewart, George Stouffer, Daisuke Sueta, Kenji Takazawa, Ji-Guang Wang, Thomas Weber, Berend Westerhof, Bryan Williams, Hirotsugu Yamada, Eiichiro Yamamoto, James Sharman
Pages: 73 - 74
Objectives: Accurate blood pressure (BP) measurement is critical for appropriate hypertension diagnosis and management. Aortic BP represents pressure loading on vital organs and this can be approximated using upper arm cuff BP. With advancing age, cuff systolic BP (SBP) increases and diastolic BP (DBP)...
Conference Abstract

41. 3.6 BLOOD PRESSURE REDUCTION IS THE MAIN DETERMINANT OF THE DE-STIFFENING EFFECT OF ANTIHYPERTENSIVE TREATMENT: A META-REGRESSION ANALYSIS AND COMPARISON WITH ACUTE MODULATION OF TRANSMURAL PRESSURE

Andrii Boguslavskyi, Benyu Jiang, Haotian Gu, Yao Lu, Marina Cecelja, Phil Chowienczyk
Pages: 74 - 74
Background: Pulse wave velocity (PWV) is independent predictor of cardiovascular outcomes. Antihypertensive treatment reduces PWV, but it is unknown whether this results from an unloading of stiffer elements in the arterial wall or a structural change in the wall. Methods: To distinguish between these...
Conference Abstract

42. 3.7 PULSE WAVE VELOCITY IS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR EVENTS, MORTALITY AND DECLINE IN RENAL FUNCTION IN PATIENTS WITH TYPE 1 DIABETES

Tine Willum Hansen, Marie Frimodt-Møller, Simone Theilade, Nete Tofte, Tarun Veer Singh Ahluwalia, Peter Rossing
Pages: 74 - 74
Purpose: The prognostic significance of carotid-femoral pulse wave velocity (cfPWV) remains to be determined in patients with type 1 diabetes (T1D). We investigated the predictive value of cfPWV for various endpoints in T1D. Methods: At baseline, cfPWV was measured using the SphygmoCor device in 652...
Conference Abstract

43. 3.8 CHILDHOOD OBESITY: DOES IT HAVE ANY EFFECT ON YOUNG ARTERIES?

Erzsébet Valéria Hidvégi, Andrea Emese Jakab, Miklós Illyés, Attila Cziráki
Pages: 75 - 75
Background: Prevalence of overweight (OW) and obesity (O) in children and adolescents has been increased in the past three decades. Obese children are prone to develop early cardiovascular (CV) morbidity in their adult life. Impaired arterial stiffness might be detected in this population. The aim of...
Conference Abstract

44. 4.1 PROBING ARTERIAL STIFFNESS AT THE NANO-SCALE USING THE INTERNAL MAMMARY ARTERY AS A NOVEL TARGET

Riaz Akhtar, Zhuo Chang, Maria Lyck Hansen, Hans Christian Beck, Lars Melholt Rasmussen
Pages: 75 - 75
Introduction: Arterial stiffening is associated with structural and biomechanical alterations in the aorta. However, there are still gaps in our understanding as to how the structure and properties of arteries across the vasculature are altered with high PWV.Objective: To determine whether altered ultrastructural...
Conference Abstract

45. 4.2 DISCREPANCY BETWEEN IN-VIVO MEASURE AND EX-VIVO CALCULATION OF PULSE WAVE VELOCITY IN RETINAL ARTERIES

Mahdieh Rezaeian, Arthur Leloup, Angela Schulz, Mojtaba Golzan, Stuart Graham, Alberto P. Avolio, Mark Butlin
Pages: 75 - 75
Background: Pulse wave velocity (PWV) in large arteries is a pressure-dependent marker of arterial stiffness. The retinal vasculature provides unique access to the microcirculation. There is inconsistency between reported values of retinal PWV (rPWV). The pressure dependency of rPWV was measured in-vivo...
Conference Abstract

46. 4.3 WHOLE-BODY VS. REGIONAL ARTERIAL STIFFNESS: IMPLICATIONS FOR A SINGLE WINDKESSEL MODEL OF THE CIRCULATION

Joseph Izzo, Sherif El-sayed, Rahil Ahmed, Peter Osmond, Benjamin Gavish
Pages: 75 - 76
Introduction: We questioned whether a single Windkessel (WK) adequately describes the circulation by estimating the radial arterial diastolic pressure-decay constant (tau) and combining this with systemic hemodynamic and arterial stiffness measurements. Methods: In the non-invasive cardiac laboratory,...
Conference Abstract

47. 4.4 CAN LASER DOPPLER VIBROMETER DETECT CAROTID STENOSIS FROM SKIN VIBRATIONS? HYDRAULIC BENCH TESTS ON PATIENT-SPECIFIC MODEL

Viviana Mancini, Daniela Tommasin, Yanlu Li, Roel Baets, Stephen Greenwald, Patrick Segers
Pages: 76 - 76
Background: Within the H2020 CARDIS project, we explore the use of a Laser Doppler Vibrometer (LDV) [1] to detect asymptomatic carotid stenosis from measurement of skin vibrations on the neck of affected patients. We hypothesise that flow instabilities induced by the stenosis will propagate as mechanical...
Conference Abstract

48. 4.5 CARDIAC OUTPUT ESTIMATION FROM BEAT-TO-BEAT RADIAL PRESSURE AND PULSE WAVE VELOCITY: A MODEL-BASED STUDY

Vasiliki Bikia, Stamatia Pagoulatou, Theodore G. Papaioannou, Nikolaos Stergiopulos
Pages: 76 - 76
Background: Cardiac output (CO) monitoring remains a salient challenge. The state-of-the-art is based on generalized transfer functions and parameter estimations from pooled clinical data, which do not necessarily reflect the state of the cardiovascular system in a patient-specific way. Here, we introduce...
Conference Abstract

49. 4.6 INFLAMMATION AND AORTIC STIFFNESS. A MULTICENTRE LONGITUDINAL STUDY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Luca Zanoli, Kadir Ozturk, Maria Cappello
Pages: 77 - 77
Background: Inflammatory Bowel Disease (IBD) is characterized by a low prevalence of traditional risk factors, an increased aortic pulse-wave velocity (aPWV) [1] and an excess of cardiovascular events. We have previously hypothesized that the difference between expected and observed cardiovascular risk...
Conference Abstract

50. 4.7 THE EFFECT OF TRANSCATHETER AORTIC VALVE IMPLANTATION ON AORTIC STIFFNESS AND HEMODYNAMICS

Vasiliki Gardikioti, D. Terentes-Printzios, C. Vlachopoulos, K. Toutouzas, M. Xanthopoulou, G. Benetos, G. Latsios, V. Penesopoulou, V. Tsigkou, G. Siasos, E. Vavuranakis, D. Tousoulis
Pages: 77 - 77
Purpose/Background/Objectives: Aortic stiffness and central hemodynamics are established vascular biomarkers. Transcatheter aortic valve implantation (TAVI) is a promising new technique for the treatment of aortic valve stenosis in elderly patients. We examined the effect of TAVI on the elastic properties...
Conference Abstract

51. 4.8 PLACENTAL NA/K-ATPASE INHIBITOR MARINOBUFAGENIN INDUCES ARTERIAL WALL FIBROSIS IN PREECLAMPSIA

Olga Fedorova, Natalia Aglakova, Yulia Grigorova, Vitalily Reznik, Valintina Zernetkina, Wen Wei, Edward Lakatta, Alexei Bagrov
Pages: 77 - 78
Background: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). Immunoneutralization of heightened MBG by Digibind, a digoxin antibody, reduces blood pressure (BP) in patients with PE, and anti-MBG monoclonal...
Conference Abstract

52. 5.1 STRESS-INDUCED SYMPATHETIC ACTIVITY AND THE RETINAL VASCULATURE: THE SABPA PROSPECTIVE STUDY

Leoné Malan, Nicolaas Malan, Wayne Smith
Pages: 78 - 78
Objectives: Retinal vessels are part of the intracranial vasculature and analysis thereof complements behavioural and brain measures. Mental stress was related to downregulation of norepinephrine in Africans. Hence we continue by assessing prospective associations between sympathetic nervous system activity...
Conference Abstract

53. 5.2 DIFFERENTIAL CHARACTERISTICS BETWEEN AORTIC PRESSURE AUGMENTATION AND CAROTID FLOW AUGMENTATION: CLINICAL IMPLICATIONS FOR CEREBRAL WHITE MATTER HYPERINTENSITIES

Junichiro Hashimoto, Berend Westerhof, Sadayoshi Ito
Pages: 78 - 78
Background: Aortic stiffness and pressure wave reflection have been found to be associated with age-related cerebral microvascular disease, but the underlying mechanism remains obscure. We hypothesized that cerebral (carotid) flow augmentation potentially mediates these associations. Methods: Doppler...
Conference Abstract

54. 5.3 CAROTID ARTERY STIFFNESS INCREASES THE RISK OF INCIDENT DEPRESSIVE SYMPTOMS: THE PARIS PROSPECTIVE STUDY 3

Thomas van Sloten, Pierre Boutouyrie, Muriel Tafflet, Lucile Offredo, Frédérique Thomas, Catherine Guibout, Rachel Climie, Cedric Lemogne, Bruno Pannier, Stephane Laurent, Xavier Jouven, Jean-philippe Empana
Pages: 78 - 79
Background: Late-life depression is related to poor quality of life and increased risk of mortality and cardiovascular disease. Effective interventions for prevention and treatment of late-life depression need to be developed, which requires a better understanding of late-life depression risk factors....
Conference Abstract

55. 5.4 AGE-INDUCED INCREASE IN THE ENERGY TRANSMITTED TOWARDS THE CEREBRAL CIRCULATION AS A CONTRIBUTOR TO IMPAIRED BRAIN FUNCTION

Stamatia Pagoulatou, Jonathan Mynard, Vasiliki Bikia, Julio Chirinos, Nikolaos Stergiopulos, Patrick Segers
Pages: 79 - 79
Background and Aims: The increase in arterial stiffness and pressure pulsatility with age is identified as a key contributor to cognitive impairment; nevertheless, the underlying hemodynamic mechanisms remain unclear. A hypothesis, proposed by (1), suggests that the preferential stiffening of the central...
Conference Abstract

56. 5.5 MEDIATOR EFFECT OF CARDIORESPIRATORY FITNESS ON THE RELATIONSHIP BETWEEN ARTERIAL STIFFNESS AND COGNITIVE FUNCTION

Alinne Nascimento, Raquel Silva, Joana Carvalho, Lucimere Bohn
Pages: 79 - 79
Objective: The study aims to investigate the role of cardiorespiratory fitness as a mediator of the relationship between arterial stiffness and cognitive function in apparently healthy seniors. Methods: This is a cross-sectional study comprising 155 participants (75.5 ± 6.5 years; 69.7% female). Arterial...
Conference Abstract

57. P1 DETERMINANTS OF PERIPHERAL PULSE PRESSURE AND PULSE PRESSURE AMPLIFICATION

Ye Li, Antoine Guilcher, Samuel Vennin, Jordi Alastruey-arimon, Phil Chowienczyk
Pages: 80 - 80
Conference Abstract

58. P2 DETERMINATION OF LOCAL PULSE WAVE VELOCITY DOES NOT AFFECTED BY REFLECTION

Ye Li, Ashraf Khir
Pages: 80 - 80
Objective: PWV is an important indicator of arterial stiffness and cardiovascular diseases. Local PWV would provide a more accurate estimation of local stiffness than does regional PWV. Local PWV is commonly determined by loop techniques, such as the PU-loop method and the aim of this study is to examine...
Conference Abstract

59. P3 UNDERSTANDING THE ENDOTHELIAL – SMOOTH MUSCLE – FIBROBLASTIC CELLS INTERACTIONS ON A TISSUE-ENGINEERED VASCULAR GRAFT

Tatiana Felizardo, Nuno M. Neves, Albino Martins, Rui L. Reis
Pages: 80 - 81
There is still a pressing need to develop small-diameter vascular vessels for vascular reconstructive procedures. Tissue Engineering offers the prospect of being able to meet this medical demand, as it allows the development of structurally complex blood vessels substitutes 1. Accordingly, the ultimate...
Conference Abstract

60. P5 REGIONAL VARIATIONS IN THE MICROMECHANICAL AND BIOCHEMICAL PROPERTIES OF THE OVINE AORTA

Phakakorn Panpho, Riaz Akhtar, Jill Madine, Mark Field
Pages: 81 - 81
Background: It is important to understand regional variations in the mechanical and biochemical properties of the aorta to better predict and treat diseases. Although previous studies have been explored regional differences in the structure and biomechanical properties of the aorta, little is known about...
Conference Abstract

61. P6 ARTERIAL STRUCTURE AND COAGULATION IN AGEING NAKED MOLE RATS

Takouhie Mgrditchian-Griffo
Pages: 81 - 81
Vascular stiffening and a prothrombotic state consistently increase with age. Naked mole rats (NMRs) among rodent species have a maximum lifespan exceeding 30 years. Arterial stiffness assessed by pulse wave velocity and arterial pressure have been shown not to increase with age in NMRs (Grimes et al....
Conference Abstract

62. P7 TELOMERE LENGTH AND AORTIC VALVE CALCIFICATION

Ilona Saraieva, Simon Toupance, Magnus Back, Benetos Athanase
Pages: 81 - 82
Background: Short telomere length (TL) is associated with atherosclerosis development. Aortic valve stenosis, an age-related disease characterized by narrowing of the aortic opening, is mainly caused by aortic valve calcification. Development of aortic calcifications shares many similarities with atherogenesis,...
Conference Abstract

63. P4 MECHANISM OF PROANGIOGENIC ACTIVITY OF MITOCORRECTIN ON ENDOTHELIAL CELLS IN VITRO

Tetiana Nikolaienko, Victoriia Nikulina, Liudmyla Garmanchuk, Oleksander Makarenko
Pages: 81 - 81
Background: Investigations of different effective treatment modalities of infectious and inflammatory complications of stroke remain relevant. Normalization of vascularization, impaired due to hypoxia, is an important component of ischemic disease treating. The aim of our work was to study the mechanism...
Conference Abstract

64. P8 THE EFFECT OF CAFFEINE ON MENTAL STRESS RELATED CARDIOVASCULAR RESPONSE

Ziva Melik, Ksenija Cankar
Pages: 82 - 82
Background: Caffeine, the most widely used pharmacologically active substance causes mental stimulation and a slight raising of blood pressure. The aim of our work was to evaluate the effect of caffeine on the cardiovascular system during rest and during mental stress. Methods: RR interval duration,...
Conference Abstract

65. P10 COMBINATION OF FLOW-MEDIATED DILATION AND PULSE WAVE VELOCITY PROVIDES FURTHER CARDIOVASCULAR RISK STRATIFICATION IN PATIENTS WITH CORONARY ARTERY DISEASE: FLOW-MEDIATED DILATION JAPAN STUDY A (FMD-J A)

Yukihito Higashi, Tatsuya Maruhashi, Hirofumi Tomiyama, Bonpei Takase, Toru Suzuki, Yasuki Kihara, Akira Yamashina
Pages: 82 - 82
Purpose/Background/Objective: The usefulness of vascular function tests for management of patients with coronary artery disease (CAD) has not been fully investigated. Methods: We measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with CAD for assessment...
Conference Abstract

66. P11 EFFECT OF AGING ON THE PRESSURE ASYMPTOTE AND TIME CONSTANT OF EXPONENTIAL DIASTOLIC AORTIC PRESSURE DECAY IN HUMANS

Tetsu Yamakado
Pages: 82 - 82
There are few data regarding the effect of aging on pressure asymptote (Pasymptote) and time constant (Tau) of exponential diastolic aortic pressure (AoP) decay in normal human heart. To investigate this issue, we analyzed high-fidelity AoP, measured by use of a catheter-tipped manometer in 71 normal...
Conference Abstract

67. P12 VALIDATION OF SYNTHESIZED CENTRAL PRESSURE WAVEFORM IN PATIENTS WITH AN INFRARENAL AORTIC ANEURYSM BEFORE AND AFTER ENDOVASCULAR REPAIR

Suzanne Holewijn, Lennart van der Velde, Majorie van Helvert, Thomas Urgert, Gerike Buitenhuis, Erik Groot Jebbink, Michel Reijnen
Pages: 82 - 83
Background: Abdominal aortic aneurysm (AAA) disease is mainly treated by endovascular aneurysm repair (EVAR), which shows short-term advantages in terms of lower morbidity and mortality compared to open repair. Long-term outcome seems te be inferior with regard to survival. This could partly be explained...
Conference Abstract

68. P13 VASCULAR AND MUSCLE DETERIORATION IN OLDER OUTPATIENTS

Lisanne Tap, Linda Kannegieter, Antine Flikweert, Francesco Mattace Raso
Pages: 83 - 83
Background: Vascular and muscle deterioration are age-related processes, which both have a major impact on health and might share common predisposing factors and mechanisms. We investigated the possible association between aortic stiffness and physical performance in older outpatients. Methods: Aortic...
Conference Abstract

69. P14 REFERENCE VALUES OF THE WEST SPANISH POPULATION OF THE HEMODYNAMIC INDICES EVALUATED WITH A NEW WRIST WORN DEVICE

Marta Gomez-Sanchez, Leticia Gomez-Sanchez, Rosario Alonso-Domínguez, Jesus Gonzalez-Sanchez, Cristina Agudo- Conde, Natalia Sánchez-Aguadero, Carmela Rodriguez-Martin, Luis Garcia-Ortiz
Pages: 83 - 84
Objective: To describe the reference value of arterial stiffness parameter measurement by wrist worn device (Microsoft) in west Spanish population. Methods: Cross-sectional study. Study population: From the population assigned to the participating healthcare centres, a cluster random sampling stratified...
Conference Abstract

70. P15 EFFECT OF UPRIGHT POSTURE ON CENTRAL WAVE REFLECTION IN 637 VOLUNTEERS NOT USING MEDICATIONS WITH DIRECT CARDIOVASCULAR INFLUENCES: DESCRIPTION OF DIFFERENT PHENOTYPES

Ilkka Pörsti, Matias Wilenius, Antti Tikkakoski, Arttu Eräranta, Manoj Kumar Choudhary, Jenni Koskela, Anna Tahvanainen, Jukka Mustonen
Pages: 84 - 84
Background: The effect of upright posture on the level of augmentation index (AIx) remains controversial [1–3]. Phenotypic differences in AIx responses to upright posture are unknown. Methods: Altogether 323 women and 315 men without cardiovascular disease and medications with direct cardiovascular...
Conference Abstract

71. P16 PULSE WAVE VELOCITY AND ITS ASSOCIATION WITH FIRST CARDIOVASCULAR EVENTS IN A PORTUGUESE HYPERTENSIVE SAMPLE

Clarinda Neves, Joana Ricardo Pires, Verónica Ribau, José Mesquita Bastos
Pages: 84 - 84
Objective: Pulse Wave Velocity (PWV) is considered a marker of cardiovascular (CV) risk prognosis. The objective was to evaluate the association of PWV, other features and CV events in a sample of hypertensive patients. Design and method: We studied 314 hypertensive patients without previous CV events...
Conference Abstract

72. P17 ARTERIAL STIFFNESS OF THE FOREARM IS ASSOCIATED WITH NAILFOLD CAPILLARY COUNT IN SYSTEMIC SCLEROSIS: A NOVEL MARKER OF EARLY VASCULOPATHY?

Anniek van Roon, Amaal Eman Abdulle, Arie van Roon, Saskia van de Zande, Hendrika Bootsma, Andries Smit, Udo Mulder
Pages: 84 - 85
Background: Microvascular disease, with rarefaction of nailfold capillaries, is the hallmark of systemic sclerosis (SSc). Obliteration of the ulnar and radial artery is regularly observed, implicating involvement of the forearm arteries. Pulse wave velocity (PWV) may serve as early biomarker of forearm...
Conference Abstract

73. P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET HYPOPITUITARISM

Isabela Biscotto, Valeria Costa-Hong, Luiz Bortolotto, Luciani Carvalho
Pages: 85 - 85
Objective: To evaluate the human recombinant growth hormone replacement (hrGHr) in the metabolic parameters and vascular system in adult patients with childhood onset hypopituitarism (COH). Patients and methods: Fifty-one adult with COH were selected for the study. They were divided into 2 groups: 1-...
Conference Abstract

74. P20 BRACHIAL AND RADIAL SYSTOLIC BLOOD PRESSURE ARE NOT THE SAME: POTENTIAL IMPLICATIONS FOR VALIDATION PROTOCOLS INCLUDING BRACHIAL CUFF DEVICES AND WRIST-BASED WEARABLES

Matthew Armstrong, Martin Schultz, Dean Picone, James Sharman, Nathan Dwyer, Philip Roberts-Thomson, Andrew Black
Pages: 85 - 85
Introduction: Radial intra-arterial blood pressure (BP) is sometimes used as the reference standard for validation of brachial cuff BP devices, and there is an emerging ‘wearables’ market seeking to measure BP at the wrist. However, brachial systolic BP may not be a good representation of the radial...
Conference Abstract

75. P21 CHARACTERIZATION OF AN ATHEROSCLEROTIC PHENOTYPE

Pedro Forcada, Castellaro Carlos, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon, Jorge Chiabaut Svane
Pages: 85 - 86
Background: Interaction between gentics and epigenetics has been largely described in Atherosclerotic Disease and the relations varies widely according to the population, clinical characteristics and the study type. Objective: Compare genetic and epigenetic factors in two middle age populations with...
Conference Abstract

76. P18 AORTIC STIFFNESS IN AORTIC STENOSIS: SHORT TERM HEMODYNAMIC CHANGES AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION

Jeannette Goudzwaard, Nahid El Faquir, Nicolas van Mieghem, Marjo de Ronde-Tillmans, Mattie Lenzen, Peter de Jaegere, Francesco Mattace-Raso
Pages: 85 - 85
Background: Both aortic valve stenosis as aortic stiffness are moderators of arterio-ventricular coupling and independent predictors of cardiovascular morbidity and mortality. Studies on the effect of Transcatheter Aortic Valve Implantation (TAVI) on hemodynamic parameters are limited. We performed a...
Conference Abstract

77. P22 THE ROLE OF RENAL DYSFUNCTION ON TARGET ORGAN DAMAGE AND CARDIOVASCULAR RISK IN HYPERTENSIVES

Eirini Solomou, Dimitrios Terentes Printzios, Charalampos Vlachopoulos, N. Ioakimidis, K. Aznaouridis, I. Koutagiar, V. Gardikioti, E. Sigala, D. Tousoulis
Pages: 86 - 86
Purpose/Background/Objective: Hypertension is associated with increased left ventricular (LV) hypertrophy, aortic stiffness and renal dysfunction, which are all predictors of cardiovascular risk. We investigated the effect of renal dysfunction on LV mass and aortic stiffness in hypertensives. Methods:...
Conference Abstract

78. P23 THE COMPARISON OF PROGNOSTIC VALUE AMONG ANKLE BRACHIAL PRESSURE INDEX, ARTERIAL STIFFNESS AND PRESSURE WAVE REFLECTION IN SUBJECTS WITH CORONARY ARTERY DISEASE

Kazutaka Kimura
Pages: 86 - 86
Objectives: The present retrospective study was conducted to compare the prognostic value among ankle brachial pressure index (ABI), brachial-ankle pulse wave velocity (baPWV,) and radial augmentation index (rAI) in patients with coronary artery disease (CAD). Methods: ABI, baPWV and rAI were measured...
Conference Abstract

79. P24 BRACHIAL AND CENTRAL SYSTOLIC BLOOD PRESSURES FROM TWO OSCILLOMETRIC DEVICES (SPHYGMOCOR AND MOBIL-O-GRAPH) OVERESTIMATE HIGH FIDELITY INTRA-ARTERIAL MEASUREMENTS IN CHILDREN AND ADOLESCENTS: RESULTS OF THE KIDCOREBP STUDY

Jonathan Mynard, Greta Goldsmith, Lucas Eastaugh, Geoff Lane, Gabriella Springall, Alberto Avolio, Joe Smolich, Michael Cheung
Pages: 86 - 87
Objective: This study investigated the accuracy of two oscillometric devices for measuring brachial and central blood pressures (BP) in children and adolescents, using high fidelity intra-arterial measurements as a gold-standard reference. Methods: 57 children and adolescents aged 9.5 ± 4.6 years (mean...
Conference Abstract

80. P25 24-HOUR AORTIC AMBULATORY BLOOD PRESSURE IS BETTER ASSOCIATED WITH COMMON CAROTID ARTERY HYPERTROPHY THAN 24-HOUR BRACHIAL PRESSURE – THE SAFAR STUDY

Antonios Argyris, Evaggelia Aissopou, Efthymia Nasothymiou, Theodoros Papaioannou, Jacques Blacher, Michel Safar, Petros Sfikakis, Athanase Protogerou
Pages: 87 - 87
Objective: Evidence suggests the superiority of office aortic pressure over brachial on the evaluation of vascular damage and prognosis of cardiovascular disease (CVD); 24-hour ambulatory blood pressure monitoring (ABPM) is regarded the optimal method for assessing blood pressure (BP) profile. The non-invasive...
Conference Abstract

81. P27 INVASIVE CENTRAL PULSE PRESSURE IS RELATED TO AORTIC ROOT DILATATION

Francesco Tosello, Andrea Guala, Dario Leone, Martina Bollati, Luca Sabia, Fabrizio D’Ascenzo, Claudio Moretti, Franco Veglio, Luca Ridolfi, Alberto Milan
Pages: 87 - 87
Background: Aortic root dilation is an established risk factor for aortic dissection. Despite the relations between aortic root remodeling, carotid-femoral pulse wave velocity (cfPWV) and aortic blood pressure have been advocated by several clinical studies and is supported by physical law, invasive...
Conference Abstract

82. P29 MECHANISMS OF VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITION INDUCED HYPERTENSION

Kaisa Maki-Petaja, Adam McGeoch, Lucy Yang, Annette Hubsch, Carmel McEniery, Fraz Mir, Parag Gajendragadkar, Nicola Ramenatte, Gayathri Anandappa, Christoph Brune, Yoeri Boink, Carola Bibiane-Schonlieb, Paul Meyer, Simon Bond, Ian Wilkinson, Duncan Jodrell, Joseph Cheriyan
Pages: 87 - 88
Introduction: Drugs targeting Vascular Endothelial Growth Factor (VEGF) signaling pathway are approved therapies for cancer. Unfortunately, VEGF inhibitors lead to hypertension in 30-80% patients. Reduced nitric oxide synthase activity and increased vascular resistance have been proposed as potential...
Conference Abstract

83. P30 A 12-WEEK EXERCISE TRAINING PROGRAM REDUCES ENDOTHELIAL DAMAGE IN RESISTANT HYPERTENSION

Susana Lopes, Catarina Garcia, Ana Gonçalves, Ilda Ribeiro, Joana Barbosa de MElo, Veronica Ribau, Daniela Figueiredo, João Viana, Susana Bertoquini, Jorge Polónia, José Mesquita-Bsstos, Alberto Alves, Fernando Ribeiro
Pages: 88 - 88
Background: Resistant Hypertension (RH) is associated with an increased risk of cardiovascular events and poor prognosis. Exercise training studies in RH patients have shown promising outcomes, nonetheless, none determine the impact of exercise on endothelial damage and repair. Circulating endothelial...
Conference Abstract

84. P31 DO TREATMENT INDUCED CHANGES IN ARTERIAL STIFFNESS AFFECT LEFT VENTRICULAR STRUCTURE AND FUNCTION? – A META-ANALYSIS

Koen van der Waaij, Maarten Heusinkveld, Tammo Delhaas, Abraham Kroon, Koen Reesink
Pages: 88 - 88
Background: Vascular research demonstrated that pulse wave velocity (PWV), a measure of arterial stiffness, is inherently blood pressure-dependent. Considering the hypothesised pathophysiological chain of increased arterial stiffness leading to increased blood pressure load with consequent left ventricle...
Conference Abstract

85. P32 DETERMINING CARDIAC AND ARTERIAL CONTRIBUTIONS TO CENTRAL PULSE PRESSURE

Samuel Vennin, Ye Li, Marie Willemet, Henry Fok, Haotian Gu, Peter Charlton, Jordi Alastruey, Phil Chowienczyk
Pages: 88 - 89
We examined the ability of a simple reduced model comprising a proximal characteristic impedance linked to a Windkessel element to accurately predict central Pulse Pressure (PP) from aortic blood flow, verified that parameters of the model corresponded to physical properties, and applied the model to...
Conference Abstract

86. P34 DETERMINANTS OF PERIPHERAL WAVE REFLECTION IN A LARGE TREATED HYPERTENSIVE POPULATION

Luiz Bortolotto, Eva Kosa, Nadja Mendes, Valeria Costa-Hong
Pages: 89 - 89
Objective: To evaluate the determinants of the peripherial wave reflection measured by the second derivative of the fingertip photoplethysmogram (SDPTG) among known cardiovascular (CV) risk factors in a large treated hypertensive population. Population and Methods: We studied prospectively 316 hypertensive...
Conference Abstract

87. P35 ARTERIAL STIFFNESS AND CHRONIC STRESS: ROLE OF GENDER – RIGIDITà ARTERIOSA E STRESS CRONICO: RUOLO DEL GENERE

Rachele Gherardini
Pages: 89 - 89
Aim: Evaluate whether exposure to chronic stress is associated with early vascular aging in hypertensive patients and possible gender differences in this relationship. Methods: Patients where recruited in a Hypertension outpatient clinic during a visit for the evaluation of subclinical organ damage....
Conference Abstract

88. P36 PULSE WAVE VELOCITY (PWV) RESPONSES TO 3 MONTHS OF YOGA POSES AND RESPIRATORY CONTROL (UJJAYI PRANAYAMA) IN HYPERTENSIVE POST MENOPAUSE WOMEN: RANDOMIZED CLINICAL TRIAL

Cláudia Fetter, Bruna Eibel, Liliana Boll, Eduardo Barbosa, Maria Cláudia Irigoyen
Pages: 89 - 89
Background: Non-pharmacological management of hypertension includes regular exercises. Yoga has been pointed as effective on treatment of hypertension. Its many aspects like yoga poses (asanas), respiratory control (pranayamas), meditation and others have not yet been assessed separately to understant...
Conference Abstract

89. P37 PULSE WAVE VELOCITY: DEPENDENCE ON CONTEMPORANEOUS AND HISTORICAL BLOOD PRESSURE COMPONENTS

Louise Keehn, Marina Cecelja, Phil Chowienczyk
Pages: 89 - 90
Background: Arterial stiffness as measured by PWV along the aorta is an important determinant of cardiovascular risk. PWV is known to be dependent on contemporaneous blood pressure (BP) but its dependence on long-term BP has not been established. Methods: Subjects from Twins UK who had tonometric measures...
Conference Abstract

90. P38 DIFFERENCES IN FORM FACTOR CALCULATED FROM OSCILLOMETRIC OR WAVEFORM MEAN ARTERIAL PRESSURE

Chloe Park, Therese Tillin, Nish Chaturvedi, Alun Hughes
Pages: 90 - 90
Background: Oscillometric mean arterial pressure (MAP) agrees closely with invasive MAP, [1] but most devices do not report MAP and it is usually estimated by a form factor (FF). However, blood pressure (BP) measurement errors will affect FF, its correlations with exposures, and introduce errors into...
Conference Abstract

91. P39 ACUTE RESPONSES OF PULSE WAVE REFLECTION AFTER AEROBIC EXERCISE WITH DIFFERENT VOLUMES

Tainah Lima, Felipe Cunha, Walace Monteiro, Paulo Farinatti, Mário Neves
Pages: 90 - 90
Background: Although Aerobic Exercise (AE) has been recognized for lowering Blood Pressure (BP), little is known about the alterations in aortic BP after exercise (1,2). PURPOSE: To investigate the acute pulse wave reflection responses induced by AE with different volumes in normotensive and hypertensive...
Conference Abstract

92. P41 INCREASED STIFFNESS IN THE DIGITAL ARTERIES OF ESSENTIAL HYPERTENSIVE WOMEN: THE FUCHSIA STUDY

Rosa Maria Bruno, Nicole Di Lascio, Saverio Vitali, Piercarlo Rossi, Rachele Gherardini, Stefano Taddei, Francesco Faita, Davide Caramella, Lorenzo Ghiadoni
Pages: 90 - 90
Rationale and Aim: Essential hypertension is characterized by extensive alterations of arterial geometry and mechanical properties: increased stiffness, dilation and wall of large arteries, increased thickness in muscular arteries, small artery remodeling. This study is aimed at exploring function and...
Conference Abstract

93. P43 MASKED HYPERTENSION AND RETINAL VESSEL STRUCTURE AND FUNCTION IN YOUNG HEALTHY ADULTS: THE AFRICAN-PREDICT STUDY

Nthai Ramoshaba, Hugo Huisman, Leandi Lammertyn, Konstantin Kotliar, Aletta Schutte, Wayne Smith
Pages: 90 - 91
Background: Masked hypertension (MH) is prevalent in young adults and is associated with similar vascular complications as sustained hypertension, but whether this is already evident in young adults is unclear. We therefore compared retinal vessel calibres and function in response to flicker light induced...
Conference Abstract

94. P45 IMPEDANCE CARDIOGRAPHY EVALUATION IN ELDERLY HYPERTENSIVE PATIENTS

Francisco Ferreira da Silva, Pedro Marques da Silva
Pages: 91 - 91
Objectives: Vascular aging results from endothelial dysfunction and increased arterial stiffness, a independent determinant of cardiovascular (CV) events, that is amplified by the presence and progression of arterial hypertension (AH). Age related changes in hemodynamic variables1 may predict negative...
Conference Abstract

95. P46 ELONGATION OF THE PROXIMAL AORTA DURING THE CARDIAC CYCLE PLAYS AN IMPORTANT ROLE IN THE ESTIMATION OF AORTIC COMPLIANCE

Stamatia Pagoulatou, Mauro Ferraro, Bram Trachet, Vasiliki Bikia, Dionysios Adamopoulos, Nikolaos Stergiopulos
Pages: 91 - 91
Background and Aims: Arterial volume compliance is a major determinant of cardiac afterload. More than 50% of the arterial volume compliance resides in the proximal aorta. Researchers often use area compliance for the estimation of volume compliance, assuming an invariant vessel length over pressure...
Conference Abstract

96. P47 ABNORMAL FLOW PATTERN IN MARFAN PATIENTS IS RELATED TO AORTIC GEOMETRIC FEATURES: A 4D FLOW MRI STUDY

Andrea Guala, Gisela Teixido-Tura, Jose Rodriguez-Palomares, Aroa Ruiz-Muñoz, David Garcia-Dorado, Artur Evangelista
Pages: 91 - 92
Introduction: Ascending aorta aneurysm and dissection are the most common cardiovascular complications affecting Marfan syndrome patients (MFS). Recent large increase in life expectancy of MFS driven the growing prevalence of descending aorta (DAo) dilation and dissection. Despite local abnormal vortices...
Conference Abstract

97. P48 COMPARISON BETWEEN INVASIVE AND NON-INVASIVE METHODS: TO EVALUATE AORTIC STIFFNESS BY PULSE WAVE VELOCITY

Andrea Grillo, Francesco Moretti, Filippo Scalise, Andrea Faini, Matteo Rovina, Lucia Salvi, Corrado Baldi, Giovanni Sorropago, Sandrine C. Millasseau, Renzo Carretta, Alberto P. Avolio, Paolo Salvi, Gianfranco Parati
Pages: 92 - 92
Objective: To investigate if invasively measured aortic pulse wave velocity (PWV) is accurately estimated by non-invasive methods purporting to assess it. Methods: One-hundred and two patients (30% female, age 65 ± 13 years) planned to undertake coronary angiography were evaluated with the following...
Conference Abstract

98. P49 QUANTIFYING WAVE REFLECTION IN CHILDREN: INVASIVE VS NON-INVASIVE CENTRAL AUGMENTATION INDEX AND REFLECTION MAGNITUDE AND THEIR ASSOCIATION WITH LEFT VENTRICULAR MASS

Jonathan Mynard, Greta Goldsmith, Remi Kowalski, Lucas Eastaugh, Geoff Lane, Gabriella Springall, Joe Smolich, Alberto Avolio, Michael Cheung
Pages: 92 - 92
Objective: The aims of this study in children were to 1) evaluate two brachial oscillometric devices for estimating central augmentation index (AIx) and reflection magnitude (RM), and 2) test whether AIx or RM are associated with left ventricular mass index (LVMI). Methods: Intra-aortic (IA) AIx was...
Conference Abstract

99. P50 VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS

Madalina Negoita, Charlotte Manisty, Anish Bhuva, Alun Hughes, Kim Parker, Ashraf Khir
Pages: 92 - 93
Background: Pulse Wave Velocity (PWV) is a measure of arterial stiffness which predicts cardiovascular risk independently of blood pressure. Local PWV can be measured non-invasively in the ascending aorta of adults by means of Ultrasound (US), using successive recordings of Diameter (D) and the velocity...
Conference Abstract

100. P51 NON-CONTACT MEASUREMENT OF LOCAL CAROTID AND CAROTID-FEMORAL PULSE WAVE VELOCITY BY LASER DOPPLER VIBROMETRY: VALIDATION OF A NEW DEVICE AGAINST REFERENCE TECHNIQUES IN HYPERTENSIVE PATIENTS

Louise Marais, Soren Aasmul, Roel Baets, Mirko De Melis, Stephen E. Greenwald, Hakim Khettab, Yanlu Li, Frits Prinzen, Koen Reesink, Patrick Segers, Pierre Boutouyrie
Pages: 93 - 93
Objective: PWV measurement devices are technically demanding, expensive and prone to artefacts, thus limiting the measurement of arterial stiffness in primary care. The CARDIS consortium developed a non-contact device based on the detection of skin movements induced by arterial pulses through a laser...
Conference Abstract

101. P52 ESTIMATING CENTRAL BLOOD PRESSURE FROM MRI DATA USING REDUCED-ORDER COMPUTATIONAL MODELS

Jorge Mariscal Harana, Peter H. Charlton, Samuel Vennin, Arna van Engelen, Torben Schneider, Mateusz Florkow, Hubrecht de Bliek, Bram Ruijsink, Israel Valverde, Marietta Charakida, Kuberan Pushparajah, Spencer Sherwin, Rene Botnar, Jordi Alastruey
Pages: 93 - 94
Purpose: Central Blood Pressure (CBP) is a better cardiovascular risk indicator than brachial pressure [1]. However, gold standard CBP measurements require an invasive catheter. We propose an approach to estimate CBP non-invasively from Magnetic Resonance Imaging (MRI) data coupled with a non-invasive...
Conference Abstract

102. P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS

Alun Hughes, Kim Parker, Ashraf Khir
Pages: 94 - 94
Background: Zero flow pressure (P∞), the steady-state pressure following cardiac arrest or cessation of flow is often assumed to equal mean circulatory filling pressure (MCFP). [1] However, this assumes complete equilibration of circulatory pressures, which may not occur if there is a ‘critical closing...
Conference Abstract

103. P54 A MACHINE LEARNING SYSTEM FOR CAROTID PLAQUE VULNERABILITY ASSESSMENT BASED ON ULTRASOUND IMAGES

Nicole Di Lascio, Claudia Kusmic, Anna Solini, Vincenzo Lionetti, Francesco Faita
Pages: 94 - 94
Purpose/Background/Objectives: Carotid plaque vulnerability assessment is essential for the identification of high-risk patients. A specific mouse model for the study of carotid atherosclerosis has been recently developed. Aim of this study was to develop a predictive mathematical model for carotid plaque...
Conference Abstract

104. P55 EFFECTS OF CAROTID PRESSURE WAVEFORM OBTAINED IN DIFFERENT WAYS ON THE RESULTS OF WAVE SEPARATION, WAVE INTENSITY AND RESERVOIR PRESSURE ANALYSIS

Nicole Di Lascio, Vincenzo Gemignani, Rosa Maria Bruno, Elisabetta Bianchini, Martina Francesconi, Francesco Stea, Lorenzo Ghiadoni, Francesco Faita
Pages: 94 - 94
Purpose/Background/Objectives: Recently great attention has been placed on innovative cardiovascular biomarkers obtained from wave separation (WS), wave intensity analysis (WIA) and the reservoir-wave (RW) concept. Pressure waveforms needed to implement these techniques can be obtained in different ways....
Conference Abstract

105. P56 CENTRAL PULSE PRESSURE IS ASSOCIATED WITH RETINAL ARTERIOLAR WALL THICKNESS AND WALL CROSS SECTIONAL AREA AS EVALUATED BY ADAPTIVE OPTICS

Antonio Gallo, Thomas Dietenbeck, Nadjia Kachenoura, Valérie Carreau, Michel Paques, Xavier Girerd
Pages: 94 - 95
Introduction: In 1991 Baumbach et al demonstrated taht pulse pressure (PP) but not mean arterial pressure (MAP) was correlated with pial arterioles wall cross-sectional area (WCSA)in rats. Adaptive optics (AO) allows a near-histological evaluation of retinal microcirculation (which shares the same embryological...
Conference Abstract

106. P57 POLYPHENOLS IN COCOA-RICH CHOCOLATE IMPROVE VASCULAR FUNCTION, THE VENTRICLE–ARTERIAL COUPLING AND COGNITIVE PERFORMANCE OF YOUNG AND HEALTHY ADULTS

Telmo Pereira, Jacqueline Bergqvist, Bente Sveälv, Joaquim Castanheira, Jorge Conde
Pages: 95 - 95
Objective: To evaluate and explore the benefits of dark chocolate in young healthy adults. Methods: Randomized study in 30 healthy participants aged 18 to 27 years. Half of the participants ingested a 20 g dose of low cocoa chocolate (LCC:∼55%; 12,61 ± 1,35 mg equivalent of epichatequin/g) and the others...
Conference Abstract

107. P58 SINGLE-PORT THORACOSCOPIC SYMPATHICOTOMY FOR TREATMENT RESISTANT RAYNAUD’S PHENOMENON: FIRST REPORT OF A NOVEL MINIMALLY INVASIVE ENDOSCOPIC TECHNIQUE

Anniek van Roon, Michiel Kuijpers, Saskia van de Zande, Arie van Roon, Massimo Mariani, Reinhard Bos, Hendrika Bootsma, Theo Klinkenberg, Andries Smit, Udo Mulder
Pages: 95 - 95
Background: Raynaud’s phenomenon of the hands is a great burden and reduces quality of life. In some patients, complaints may be resistant to vasodilatory treatment, for which additional options are very limited. Previously thoracic sympathectomy has been shown effective, but with great surgical burden....
Conference Abstract

108. P59 KNOW YOUR VASCULAR AGE: A FEASIBILITY STUDY ON A NEW SERVICE IN COMMUNITY PHARMACIES

Sofia Maximiano, Patrícia Soares, Mariana Rosa, Ana Pinto, Maria Mendes, Joana Brito, Sonja Gose, Johannes Risse, Telmo Pereira, João Maldonado, Ema Paulino
Pages: 95 - 96
Background: Multiple studies report that stiffness of the elastic arteries has a predictive value independent of cardiovascular (CV) risk. According to the 2016 European Guideline on CV Disease Prevention in Clinical Practice by the European Society of Cardiology, arterial stiffness (AS) may predict...
Conference Abstract

109. P60 INFLUENCE OF ANGER ON ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH RECENT MYOCARDIAL INFARCTION

Bruna Eibel, Alexandre Quadros, Karine Schmidt, Carlos Gottschall, Márcia Moura
Pages: 96 - 96
Background: The literature demonstrates that anger is associated with cardiovascular disease, but the underlying physiological mechanisms remain undefined. Endothelial dysfunction, present in atherosclerosis, has also been associated with anger. Purpose: To examine the association between anger and...
Conference Abstract

110. P61 ARTERIAL STIFFNESS IS ASSOCIATED WITH AORTIC VALVE CALCIFICATIONS

Dimitrios Terentes-Printzios, Vasiliki Gardikioti, Charalambos Vlachopoulos, Konstantinos Toutouzas, Maria Xanthopoulou, Vasiliki Penesopoulou, Georgios Latsios, Vicky Tsigkou, Charalambos Kalantzis, Gerasimos Siasos, Manolis Vavuranakis, Dimitrios Tousoulis
Pages: 96 - 96
Purpose/Background/Objective: Arterial stiffness and aortic hemodynamics are independent predictors of adverse cardiovascular events. Indications for Transcatheter Aortic Valve Implantation (TAVI) are increasing in number and Aortic Valve Calcifications (AVC) are an important prognostic factor of TAVI....
Conference Abstract

111. P62 DAPAGLIFLOZIN PRESERVES RENAL VASODILATING CAPACITY IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES

Rosa Maria Bruno, Livia Giannini, Angela Dardano, Edoardo Biancalana, Stefano Taddei, Lorenzo Ghiadoni, Anna Solini
Pages: 96 - 96
Aim: Mechanisms through which SGLT-2 inhibitors achieve cardiovascular and renal protection are still unknown. We investigated whether dapagliflozin modulates Na and water balance and systemic and renal vascular parameters like endothelial function, arterial stiffness and renal vasodilating capacity. Methods:...
Conference Abstract

112. P63 MODIFICATION OF SYMPATHETIC TONE BY RENAL ARTERY DENERVATION CAUSES EARLY, SIGNIFICANT AND SUSTAINED ARTERIAL DE-STIFFENING

Andrius Berukstis, Gintare Neverauskaite-Piliponiene, Nerijus Misonis, Vytautas Juknevicius, Jurate Balsyte, Aleksandras Laucevicius
Pages: 97 - 97
Objective: To examine whether Sympathetic Renal Denervation (RDN) might have an additive value for cardiovascular risk decline beyond lowering blood pressure. Methods: 73 selected patients with resistant hypertension had RDN performed. Arterial stiffness was measured, using applanation tonometry, before...
Conference Abstract

113. P65 REMOTE ISCHAEMIC PRECONDITIONING REDUCES KIDNEY INJURY IN VASCULAR SURGERY

Teele Kepler, Karl Kuusik, Urmas Lepner, Joel Starkopf, Mihkel Zilmer, Jaan Eha, Liisi Anette Torop, Jaak Kals
Pages: 97 - 97
Background: Perioperative acute kidney injury has been found to occur in 12% of patients undergoing lower limb revascularisation (Arora et al., 2013). The aim of the current double-blinded, randomised and sham-controlled pilot study was to determine the effect of remote ischaemic preconditioning (RIPC)...
Conference Abstract

114. P66 REDUCTION IN AUGMENTATION PRESSURE IS ASSOCIATED WITH IMPROVEMENT OF EARLY VENTRICULAR EJECTION AFTER AORTIC VALVE REPLACEMENT

Haotian Gu, Ronak Rajani, Phil Chowienczyk
Pages: 97 - 97
Background: Previously regarded as a measure of pressure wave reflection, central augmentation pressure (AP) may be influenced by the pattern of early ventricular ejection. We examined the relationship of AP to first-phase ejection fraction (EF1), a measure of ventricular ejection up to the time of the...
Conference Abstract

115. P67 UNRELIABLE PULSE WAVE VELOCITY VALUES PROVIDED BY ALGORITHM-BASED DEVICE: A STUDY IN MARFAN SYNDROME

Giulia Furlanis, Paolo Salvi, Andrea Grillo, Lucia Salvi, Inês Pintassilgo, Elisabetta Bungaro, Raffaella Gaetano, Susan Marelli, Renzo Carretta, Alessandro Pini, Gianfranco Parati
Pages: 98 - 98
Objective: To evaluate the reliability of algorithm-based aortic pulse wave velocity (PWV) estimated by the Mobil-O-Graph (IEM, Germany) compared to a standard non-invasive measurement of aortic PWV (carotid-femoral PWV), in a population of patients with a genetic disorder causing premature stiffening...
Conference Abstract

116. P69 RELATIONSHIP BETWEEN CAROTID INTIMA-MEDIA THICKNESS, ENDOTHELIAL FUNCTION, AORTIC STIFFNESS AND CARDIOVASCULAR EVENTS AMONG METABOLIC SYNDROME SUBJECTS

Ligita Ryliškytė, Rokas Navickas, Roma Puronaitė, Agnė Jucevičienė, Aleksandras Laucevičius
Pages: 98 - 98
Objective: The aim of this study was to evaluate predictive value of main arterial markers for cardiovascular (CV) events in subjects with metabolic syndrome (MetS). Methods: A prospective study enrolled 2728 middle-aged (53.9 ± 6.2 years old, 63% women) MetS patients of the Lithuanian High Cardiovascular...
Conference Abstract

117. P70 FINGER-TOE PULSE WAVE VELOCITY (FTPWV) MEASURED BY POPMèTRE® DEVICE IN PATIENTS WITH ANKYLOSING SPONDYLITIS

Guillermo Alanis-Sánchez, Carlos Ramos-Becerra, Ernesto Cardona-Muñóz, Diego Castañeda-Zaragoza, David Cardona-Muller, Hakim Khettab, Stephen Laurent, Pierre Boutouyrie, Hasan Obeid, Magid Hallab, Valeria Diaz-Rizo
Pages: 98 - 99
Background: Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise ethology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. Extra skeletal organs may also be affected...
Conference Abstract

118. P71 TROPONIN INCREASE AND SUBENDOCARDIAL OXYGEN SUPPLY AND DEMAND IMBALANCE IN CARDIAC AMYLOIDOSIS

Lucia Salvi, Paolo Salvi, Andrea Grillo, Gianfranco Parati, Francesco Banfi, Stefano Perlini
Pages: 99 - 99
Background: The increase in troponin is a cardiac amyloidosis (CA) peculiarity. The most acclaimed hypothesis is direct toxicity of amyloid fibrils on cardiomyocytes, but a subendocardial ischemia due to discrepancy between oxygen supply and demand imbalance has not been investigated yet. Methods: 129...
Conference Abstract

119. P72 AORTIC PULSE WAVE VELOCITY IN PATIENTS WITH COPD: 5-YEAR DATA FROM THE ARCADE STUDY

Nichola Gale, Mahfoudha Al Shezawi, Maggie Munnery, Barry Mcdonnell, John Cockcroft
Pages: 99 - 100
Background: Cardiovascular (CV) disease is a major cause of morbidity and mortality in COPD 1 . Aortic pulse wave velocity (AoPWV), an independent predictor of CV risk, is elevated in COPD 2 , however, there have been no longitudinal studies of AoPWV in COPD. The Assessment of Risk in Chronic Airways...
Conference Abstract

120. P73 AORTIC BUT NOT PERIPHERAL PULSE WAVE VELOCITY IS IMPROVED AFTER HEART RATE TARGETED AEROBIC PHYSICAL TRAINING IN METABOLIC SYNDROME SUBJECTS

Ieva Slivovskaja, Jurate Balsyte, Ligita Ryliskyte, Jolita Badariene, Rokas Navickas, Aleksandras Laucevicius
Pages: 100 - 100
Objective: To evaluate the response of aortic and peripheral arterial stiffness parameters to heart rate (HR) targeted exercise training in metabolic syndrome (MS) subjects. Methods: This cohort study included 170 individuals with MS (mean age 53.3 ± 6.9 years, 55% women). The subjects were recruited...
Conference Abstract

121. P74 SLEEP QUALITY IS ASSOCIATED WITH CEREBROVASCULAR FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS

Georgios Grigoriadis, Alexander J. Rosenberg, Sang Ouk Wee, Elizabeth C. Schroeder, Garett Griffith, Tracy Baynard
Pages: 100 - 100
Introduction: Individuals with multiple sclerosis (MS) exhibit impaired cerebrovascular function and have poor sleep quality. In the general population, poor sleep contributes to cerebrovascular dysfunction and is related to cardiovascular disease (CVD). Improving sleep quality may have beneficial effects...
Conference Abstract

122. P75 DIFFERENTIAL ELASTIN DEGRADATION AND MICROMECHANICAL PROPERTIES IN ASCENDING AORTIC ANEURYSM GROUPS: STATISTICAL MODELLING

Ya Hua Chim, Hannah Davies, Francesco Diaz De la O, Mark Field, Jill Madine, Riaz Akhtar
Pages: 100 - 100
Background: Elastin microstructure is an important factor in aortic aneurysms. However, it is unclear whether elastin microstructure varies in different ascending aneurysm aetiologies, and how this relates to micromechanical behaviour. Objective to combine in vitro experimentation and statistical modelling...
Conference Abstract

123. P76 CAROTID THERMAL HETEROGENEITY AND DYSLIPIDEMIA: THE HEAT IS ON

Iosif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Ioannis Skoumas, Evangelia Sigala, Vasiliki Gardikioti, Stavroula Pantou, Angeliki Rigatou, Nikolaos Ioakeimidis, Christos Georgakopoulos, Nikitas-Alexandros Skliros, Georgios Benetos, Spiros Galanakos, Dimitrios Tousoulis
Pages: 100 - 101
Background: Microwave Radiometry (MWR) is a new validated method, which allows evaluation of thermal heterogeneity of carotid arteries and is associated with inflammation.Purpose: The aim of this pilot study was to determine if thermal heterogeneity in the carotid arteries is associated with aortic elastic...
Conference Abstract

124. P77 TARGETED LIPIDOMICS OF ARTERIAL STIFFNESS AND HEMODYNAMICS IN ATHEROSCLEROSIS

Kaido Paapstel, Jaak Kals, Jaan Eha, Kaspar Tootsi, Aigar Ottas, Anneli Piir, Mihkel Zilmer
Pages: 101 - 101
Objectives: This study examined relationships between lipidomic profile, arterial function and hemodynamics in coronary artery disease (CAD) patients, peripheral arterial disease (PAD) patients and healthy controls. Methods: We studied 52 patients with CAD, 32 patients with PAD, and 40 apparently healthy...
Conference Abstract

125. P78 PRESSURE-INDEPENDENT ROLE OF THE AUTONOMIC NERVOUS SYSTEM IN THE REGULATION OF ARTERIAL STIFFNESS IN SUBJECTS WITH ESSENTIAL HYPERTENSION

Luca Faconti, Bushra Farukh, Philip J. Chowienczyk
Pages: 101 - 101
Objective: To test if arterial stiffness (AS) can be modulated by the autonomic nervous system (ANS) independently of blood pressure (BP) in hypertensive patients. Material and methods: AS was measured by carotid-femoral pulse wave velocity (cfPWV) using the SphygmoCor device (AtCor Medical, Australia)....
Conference Abstract

126. P79 AORTIC VISCOELASTIC PROPERTIES AND ALTERED ELECTROMECHANICAL CARDIO-AORTIC CONNECTION IN PATIENTS WITH CARDIAC AMYLOIDOSIS

Lucia Salvi, Paolo Salvi, Andrea Grillo, Stefano Perlini, Gianfranco Parati
Pages: 101 - 101
Background: Cardiac amyloidosis (CA) is an infiltrative disorder caused by deposition of amyloid fibrils in the myocardial extracellular matrix. A wide scientific literature regarding amyloid heart disease is available, but no data about aortic viscoelastic properties. This studio has the aims to start...
Conference Abstract

127. P80 ANALYSIS OF ENDOTHELIAL FUNCTION IN MALE STUDENTS IN SOUTHERN BRAZIL: THE ROLE OF PHYSICAL ACTIVITY

Marcos Paulo Camboim, Bruna Eibel, Lucia Pallanda, Salvador Neto, Gustavo Waclawovsky, Vitor Kunrath
Pages: 101 - 102
Context: School adolescents in Porto Alegre have a mean physical inactivity (PI) <300 min/week of 43%, and another 13% do not perform physical activities. In this scenario, endothelial cells that regulate vascular homeostasis by the expression of bioactive mediators may be influenced by inflammatory...
Conference Abstract

128. P82 REDUCTION IN ENDOTHELIAL, BUT NOT MICROVASCULAR, FUNCTION DURING ACUTE INFLAMMATION: PRELIMINARY RESULTS

Elizabeth Schroeder, Thessa Hilgenkamp, Tracy Baynard, Bo Fernhall
Pages: 102 - 102
Acute inflammation is associated with increased risk for cardiovascular events and leads to reductions in conduit artery (flow-mediated dilation, FMD) and resistance vessel endothelial function. Whether this dysfunction during acute inflammation is further transmitted down the arterial tree to the microvasculature,...
Conference Abstract

129. P83 DIFFERENT PROTOCOLS FOR EARLY CARDIAC REHABILITATION MODULATE THE VASCULAR FUNCTION OF INDIVIDUALS UNDERGOING CORONARY ARTERY BYPASS GRAFTING: RANDOMIZED CLINICAL TRIAL

Bruna Eibel, Gustavo Waclawovsky, Liliana Boll, Eduardo Barbosa, Maria Cláudia Irigoyen, Alexandre Lehnen
Pages: 102 - 102
Background: Cardiac rehabilitation with aerobic exercises is the first strategy as a non-pharmacological treatment in the postoperative period of individuals undergoing coronary artery bypass grafting (CABG) to improve functional capacity and vascular health. However, other exercise modalities remain...
Conference Abstract

130. P84 RELATIONSHIP OF ARTERIAL STIFFNESS AND ANKLE-BRACHIAL INDEX

Gabriel Dimitrov, Giovanni Scandale, Gianni Carzaniga, Martino Recchia, Marzio Minola, Edoardo Perilli, Maria Carotta, Mariella Catalano
Pages: 102 - 103
The ankle-brachial index (ABI) is widely accepted as a diagnostic test used to evaluate the presence of peripheral arterial disease (PAD). 1. We investigated the associations between central arterial stiffness evaluated by measurement of aortic pulse wave velocity (aPWV), augmentation index (Aix) with...
Conference Abstract

131. P85 CEREBRAL SMALL VESSEL DISEASE AND RISK OF INCIDENT STROKE, DEMENTIA AND DEPRESSION, AND ALL-CAUSE MORTALITY: A SYSTEMATIC REVIEW AND META-ANALYSIS

Sytze Rensma, Thomas van Sloten, Lenore Launer, Coen Stehouwer
Pages: 103 - 103
Background: MRI features of cerebral small vessel disease, i.e. white matter hyperintensities, lacunes, microbleeds, perivascular spaces, and cerebral atrophy, may be associated with clinical events, but the strength of these associations remains unclear. Methods: We conducted a systematic review and...
Conference Abstract

132. P86 BLUNTED CEREBRAL MICROCIRCULATION OXYGENATION DURING EXERCISE IN NEWLY DIAGNOSED HYPERTENSIVE PATIENTS: LINKS WITH INDICES OF MACROCIRCULATION AND ARTERIAL STIFFNESS

Areti Triantafyllou, Konstantina Dipla, Nikolaos Koletsos, Alexandros-Savvas Zafeiridis, Stauros Papadopoulos, Iris Grigoriadou, Eugenia Gkaliagkousi, Andreas Zafeiridis, Stella Douma
Pages: 103 - 103
Purpose/Background/Objective: Hypertension has been considered as one of the most common modifiable risk factors for stroke and cognitive impairment. Decreased cerebral perfusion and oxygenation, as a result of capillary rarefaction and microvascular impairment of brain vessels, have been suggested as...
Conference Abstract

133. P87 CEREBROVASCULAR REACTIVITY DURING COGNITIVE ACTIVATION IN ADULTS WITH CONTROLLED HYPERTENSION

Wesley Lefferts, Jacob DeBlois, Tiago Barreira, Kevin Heffernan
Pages: 103 - 104
Hypertension, even when pharmaceutically controlled, may accelerate arterial stiffening and impair changes in blood flow necessary to support neural activity (neurovascular coupling [NVC]). Optimal NVC requires continuous, non-pulsatile flow, which is partially determined by extra- and intra-cranial...
Conference Abstract

134. P88 CENTRAL PRESSURE IN PATIENTS WITH ACUTE ISCHEMIC STROKE IN ACUTE PHASE: A PILOT STUDY

David Paiva, Ana Costa, Ana Luisa Campos, Filipa Gonçalves, Pedro Cunha, Jorge Cotter
Pages: 104 - 104
Acute Ischemic Stroke (AIS) is defined as sudden onset of a neurologic deficit. The main risk factor for stroke is high blood pressure (BP) and it is elevated in more than 70% or more of patients with AIS. In patients with AIS, management of blood pressure by brachial pressure is very important, but...
Conference Abstract

135. P89 3 HOURS UNINTERRUPTED SITTING INCREASES CEREBROVASCULAR RESISTANCE AND REDUCES CEREBRAL BLOOD FLOW IN SUBJECTS WITH INCREASED CARDIOVASCULAR RISK

Yvonne Hartman
Pages: 104 - 104
Background: Sedentary behavior has deleterious effects on cardiovascular risk. Uninterrupted sitting is associated with an impaired peripheral blood flow and vascular function. However, the relation between cerebrovascular flow and sedentary behavior is currently unknown. Impaired cerebrovascular flow...
Conference Abstract

136. P90 KINETIC ENERGY AND ENERGY LOSS IN THE MIDDLE CEREBRAL ARTERY (MCA) OF HEARTMATE II PATIENTS

Koichi Akiyama, Ruiping Ji, Autumn Clemons, Francesco Castagna, Alberto Pinsino, John R. Cockcroft, Melana Yuzefpolsakaya, Reshad Garan, Hiroo Takayama, Koji Takeda, Yoshifumi Naka, Veli Topkara, Joshua Willey, Barry J. McDonnell, Paolo Colombo, Eric Stöhr
Pages: 104 - 105
Background: In heart failure patients with continuous-flow left ventricular assist devices (CF-LVAD), arterial pulsatility in the brain is reduced and diastolic blood velocities (Vmin) are maintained. The effects of such altered hemodynamics on kinetic energy and, importantly, energy loss in the cerebral...
Conference Abstract

137. P91 THE EFFECTS OF DEVICE-GUIDED PACED BREATHING ON ARTERIAL STIFFNESS: IMPACT OF THE AUTONOMIC NERVOUS SYSTEM

Bushra Farukh, Luca Faconti, Phil J. Chowienczyk
Pages: 105 - 105
Objective: The autonomic nervous system (ANS) plays an important role in regulating blood pressure (BP), but its action on arterial stiffness (AS) is still debated. Here we examine if device-guided paced breathing (DGB) 1, via its action on ANS, can affect AS beyond its BP-lowering effect in hypertensive...
Conference Abstract

138. P92 PARAMETERS FOR CENTRAL BLOOD PRESSURE AS PREDICTORS FOR THE EARLY CLINICAL AND FUNCTIONAL OUTCOME AFTER STROKE

Katrin Holzhauser
Pages: 105 - 105
Background: High mortality and the rate of patients who depend on care after survived stroke illustrate the importance of prevention and the importance of the development of predictors to identify patients with a high risk for an adverse progress of disease. The level of the arterial blood pressure depends...
Conference Abstract

139. P93 RELATIONSHIP BETWEEN AORTIC PULSE WAVE VELOCITY AND MID CEREBRAL ARTERY PULSATILITY INDEX IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE; PILOT DATA FROM THE ARCADE STUDY

Mahfoudha Al Shezawi, John Cockcroft, Maggie Munnery, laura Watkeys, Nichola Gale, Barry McDonnell
Pages: 105 - 106
Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory condition associated with increased cardiovascular risk. COPD patients have increased aortic stiffness and increased risk of stroke. In addition, increased mid cerebral artery pulsatility index (MCAPI) is associated with increased...
Conference Abstract

140. P94 EVALUATING CENTRAL PRESSURE IN PATIENTS WITH ACUTE ISCHEMIC STROKE IN ACUTE PHASE: PROGNOSIS AND OUTCOME

Ana Costa, David Paiva, Filipa Gonçalves, Ana Campos, Pedro Cunha, Jorge Cotter
Pages: 106 - 106
Acute ischemic stroke (AIS) is defined as sudden onset of a neurologic deficit. It’s the cause of about 85% of all strokes and the deficits last for more than 24 h. (1) Blood pressure (BP) is elevated in 75% or more of patients with acute stroke and different levels of peripheral BP at onset are associated...
Conference Abstract

141. P95 BLOOD PRESSURE VARIABILITY, ARTERIAL STIFFNESS AND ARTERIAL REMODELING – THE MAASTRICHT STUDY

Tan Lai Zhou, Ronald Henry, Coen Stehouwer, Thomas van Sloten, Koen Reesink, Abraham Kroon
Pages: 106 - 106
Greater very short- to mid-term blood pressure variability (BPV) has been associated with an increased CVD risk, especially stroke. However, this link remains incompletely understood. We hypothesized that increased arterial stiffness and maladaptive carotid arterial remodeling may underlie this association....
Conference Abstract

142. P96 ASSOCIATION OF METABOLIC SYNDROME AND ITS COMPONENTS WITH ARTERIAL STIFFNESS IN GENERAL POPULATION OF THE EVA STUDY

Cristina Agudo-Conde, Leticia Gomez-Sanchez, Marta Gomez-Sanchez, Rosario Alonso-Domínguez, Natalia Sánchez-Aguadero, Cristina Lugones-Sánchez, Jesus Gonzalez-Sanchez, Sara Mora-Simon, Jose I. Recio-Rodriguez
Pages: 106 - 107
Objective: The aim of this study is to investigate the relationship of Metabolic Syndrome (MetS) and its components with arterial stiffness in general population without cardiovascular diseases. Design and method: Cross-sectional study of general population without cardiovascular diseases. There were...
Conference Abstract

143. P97 FAMILY PATTERNS OF CENTRAL HAEMODYNAMICS ACROSS THREE GENERATIONS IN THE MALMö OFFSPRING STUDY

Peter Nilsson, Erik Petersson Rosberg
Pages: 107 - 107
Background: Markers of central haemodynamics have in recent years emerged as promising predictors of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and affect organs directly attached to large arteries. Carotid-Femoral pulse wave velocity (c-f...
Conference Abstract

144. P98 AGE AND GENDER DIFFERENCES IN VARIABILITY OF WAVE REFLECTIONS OVER 24 HOURS: THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Thomas Weber, Siegfired Wasserheurer, James Sharman, Cristina Giannatasio, Piotr Jankowski, Yan Li, Alessandro Maloberti, Barry Mcdonnell, Carmel McEniery, Maria Lorenza Muisan, Janos Nemcsik, Anna Paini, Enrique Rodilla, Ian Wilkinson, Robert Zweiker, Athanase Protogerou
Pages: 107 - 107
Background: Wave reflection parameters predict cardiovascular events, but 24-hour profiles in large samples of healthy adults are unknown. Methods: In 1645 individuals free from antihypertensive drugs from 11 centers in Europe and Asia, 24-hour blood pressure monitoring with a validated oscillometric...
Conference Abstract

145. P99 STUDY ON THE PREVALENCE AND DETERMINANTS OF EARLY VASCULAR AGEING IN A COMMUNITY PHARMACY SETTING – PRELIMINARY RESULTS: FROM THE ASINPHAR@2ACTION (ARTERIAL STIFFNESS IN THE PHARMACIES TO (2) ACTION) PROJECT

Telmo Pereira, Ema Paulino, Mariana Rosa, Ana Pinto, Maria Teixeira, Patrícia Soares, Sofia Maximiano, Johannes Risse, Sonja Gose
Pages: 107 - 108
Objective: The ASINPHAR@2action programme aims at raising awareness to early vascular ageing (EVA) through a community-based intervention. This preliminary analysis is focused on the analysis of the proportion of participants with abnormal arterial stiffness (AS) and the definition of its main determinants. Design...
Conference Abstract

146. P100 THE ASSOCIATION BETWEEN DAIRY PRODUCTS CONSUMPTION AND ARTERIAL STIFFNESS: A META-ANALYSIS

Celia Álvarez-Bueno, Iván Cavero-Redondo, Alba Soriano-Cano, Diana P. Pozuelo-Carrascosa, Blanca Notario-Pacheco, Estela Jimenez-Lopez
Pages: 108 - 108
Background: Dairy products consumption has been related to some metabolic risk parameters. Specifically, some studies have associated higher intake of dairy products with lower pulse wave velocity (PWv) values, although discrepancies persist in this relationship. Objective: To determine the association...
Conference Abstract

147. P101 REFERENCE VALUES OF DIFFERENT PARAMETERS OF VASCULAR FUNCTION IN CAUCASIAN POPULATION WITHOUT CARDIOVASCULAR DISEASES. EVA STUDY

Marta Gomez-Sanchez, Leticia Gomez-Sanchez, Gristina Lugones-Sanchez, Jesus Gonzalez-Sanchez, Rosario Alonso-Dominguez, Jose I. Recio-Rodriguez, Olaya Tamayo-Morales, Manuel A. Gomez-Marcos
Pages: 108 - 108
Objective: To describe the mean values of different parameters of vascular function, evolution with age and differences by gender in the general population without cardiovascular diseases. Design and method: An observational, descriptive, cross-sectional study. Study population: From the population...
Conference Abstract

149. P103 REFERENCE VALUES IN A REPRESENTATIVE SAMPLE FOR A CERTAIN COUNTRY

Pedro Forcada, Carlos Castellaro, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon, Jorge Chiabaut Svane
Pages: 108 - 109
Background: Difference between sex, age, ethnias etc. have been described for every parameter of vascular structure and function. It is of outmost importance to know their reference values for using non invasive vascular evaluations (NIVE) in a certain population to detect subclinical aterosclerosis. Objective:...
Conference Abstract

150. P104 INFLUENCE OF AGE AND GENDER ON 24-HOUR VARIABILITY OF CENTRAL BLOOD PRESSURE: FINDINGS FROM THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Thomas Weber, Athanase Protogerou, Siegfried Wassertheurer, Cristina Giannatasio, Piotr Jankowski, Yan Li, Alessandro Maloberti, Barry McDonnell, Carmel McEniery, Maria Lorenza Muiesan, Janos Nemcsik, Anna Paini, Enrique Rodilla, Ian Wilkinson, Robert Zweiker, James Sharman
Pages: 109 - 109
Background: Conventional brachial cuff BP is known to vary according to age and gender, but the influence of these factors on 24-hour ambulatory central BP is unknown. We sought to determine this in a large healthy population from 11 centers in Europe and Asia. Methods: 24-hour ambulatory BP using a...
Conference Abstract

151. P105 PULSE PRESSURE AMPLIFICATION AND PHYSICAL ACTIVITY IN YOUNG BLACK AND WHITE ADULTS: THE AFRICAN-PREDICT STUDY

Johannes van Rooyen, Anika Kaufman, Wayne Smith, Yolandi Breet
Pages: 109 - 110
Background and Objectives: It is known that physical activity is inversely associated with arterial stiffness in healthy adults 1. Data regarding the effect of physical activity on PPA is limited. Such data is of importance especially in South Africa, where alarming rates of physical inactivity have...
Conference Abstract

152. P106 RELATIONSHIP BETWEEN CENTRAL PULSE PRESSURE AND URINARY SODIUM EXCRETION IN A POPULATION-BASED STUDY IN SALVADOR, BRAZIL, PRELIMINARY RESULTS

Lucelia Magalhaes, Daniele Brustolim, Diorlene Da Silva, Rodrigo Lima, Antonio Filho, Roberta Cunha, Jamile Gomes, Raquel Dantas
Pages: 110 - 110
Introduction: Central Pressure (PC) has shown to be more reliable in cardiovascular (CV) mortality (1); Salt intake and excretion seems to lead to an increase in this pulsatile component of the arterial flow (2, 3). C entral Pulse Pressure (PPc) data is very few. Methods: A population-based cross-sectional...
Conference Abstract

153. P107 RENAL DENERVATION IMPROVES 24-HOUR CENTRAL AND PERIPHERAL BLOOD PRESSURES, ARTERIAL STIFFNESS AND PERIPHERAL RESISTANCE

Christian Ott, Klaas Franzen, Tobias Graf, Joachim Weil, Roland Schmieder, Michael Reppel, Kai Mortensen
Pages: 110 - 110
Background: Ambulatory Blood Pressure (BP) as well as central BP are better predictors for overall cardiovascular risk and mortality than brachial BP. Renal Denervation (RDN) has been shown to reduce office brachial and central BP as well as ambulatory brachial BP, but data on central ambulatory BP are...
Conference Abstract

154. P108 ANATOMIC VARIATIONS OF RENAL ARTERIES IN PATIENTS WITH ESSENTIAL HYPERTENSION: A RETROSPECTIVE STUDY

Jorge Lourenço, Joao Cabral, Daniela Marado, Armando Carvalho
Pages: 111 - 111
Background: Aberrant renovascular anatomy has been reported to occur in up to 80% of patients with Essential Hypertension (EH). In more than 20% of subjects, at least one kidney is found to be supplied by more than one artery arising from the aorta (1). Methods: We analysed reports of renal Angiographic...
Conference Abstract

155. P109 RESERVOIR-EXCESS PRESSURE CHARACTERISTICS HELP IDENTIFY PEOPLE WITH HIGH INTRA-ARTERIAL AORTIC SYSTOLIC BLOOD PRESSURE

Elif Stoneman, Dean Picone, Martin Schultz, Matthew Armstrong, Andrew Black, Nathan Dwyer, Philip Roberts-Thomson, James Sharman
Pages: 111 - 111
Background: High aortic blood pressure (BP) predicts clinical outcomes beyond peripheral BP. Aortic BP may differ according to level of systolic BP (SBP)-amplification but these differences cannot be identified using current non-invasive BP measurement methods. In this study, we sought to determine if...
Conference Abstract

156. P110 ACUTE EFFECT OF AEROBIC, RESISTANCE, AND COMBINED EXERCISE ON BLOOD PRESSURE AND VASCULAR RESISTANCE OF HYPERTENSIVE PATIENTS: RANDOMIZED CLINICAL TRIAL

Gustavo Waclawovsky, Bruna Eibel, Liliana Boll, Maximiliano Schaun, Eduardo Barbosa, Alexandre Lehnen,
Pages: 111 - 111
Background: Exercise is part of antihypertensive therapy. However, little is known about the effect of different types of exercise on hemodynamic variables in systemic arterial hypertension (SAH). Purpose: To evaluate the effect of an aerobic (AE), resistance (RE) and combined (CE) exercise session on...
Conference Abstract

157. P111 DISCREPANCY BETWEEN BRACHIAL AND INVASIVE INTRA-AORTIC PRESSURES IN PATIENTS UNDERGOING CARDIAC CATHETERIZATION

Azra Mahmud, Ali Allghamdi, Mohammad Balghith, Kamal Ayoub, Mohammad Fayaz Khan, Samir AlChighouri, Fawaz AlMutairi, Muayad AlZaibag
Pages: 111 - 111
Introduction: Invasive intra-aortic pressures are the gold standard for accurate Blood Pressure (BP) measurement. Hypertension management is guided by brachial cuff BP although its accuracy has been questioned. Hypothesis: We hypothesized that there may be a discrepancy between brachial and invasive...
Conference Abstract

158. P112 EFFECT OF DIFFERENT TYPES OF PHYSICAL TRAINING ON THE FUNCTION ENDOTHELIAL IN HYPERTENSIVE INDIVIDUALS

Marinei Pedralli, Rafael Marschner, Eduardo Barbosa, Bruna Eibel, Alexandre Lehnen,
Pages: 112 - 112
Introduction: Endothelial dysfunction is a characteristic of systemic arterial hypertension and an early marker of atherosclerosis. Aerobic training (AT) is known to improve endothelial function, but little is known about the effects of resistance training (RT) and combined training (CT) on endothelial...
Conference Abstract

159. P113 DIURNAL RHYTHM OF CENTRAL BLOOD PRESSURE DURING TWENTY-FOUR-HOUR AMBULATORY MONITORING

Bela Benczur
Pages: 112 - 112
It’s known that ABPM is better in diagnosing hypertension than office-based measurements. Growing evidence supports that cBP is stronger predictor of cardiovascular risk than brachial BP. Dipping status of subjects can be assessed based on night-to-day BP ratio derived from ABPM. However, there is no...
Conference Abstract

160. P114 APPLICATION AND REPLICABILITY OF BILATERAL AND SIMULTANEOUS MULTIPLE ARTERIAL BLOODPRESSURE MEASUREMENTS IN SEDENTARY AND PHYSICALLY ACTIVE PROFESSIONS

Eric de Groot
Pages: 112 - 112
Background: Lack of physical activity is endemic in office life. Sedentary associated disorders include general adaptation syndrome (‘stress’), musculoskeletal, cardiovascular, metabolic and overweight. These conditions provoke absenteeism. Purpose: We evaluated applicability and replicability of a novel...
Conference Abstract

161. P115 LEUKOCYTE TELOMERE LENGTH AND ITS RELATION TO NITRIC OXIDE METABOLITES IN A BI-ETHNIC SAMPLE: THE SABPA STUDY

Hugo W. Huisman, Jan-Hendrik Combrink, Carina Mels, Aletta Schutte
Pages: 112 - 113
Objectives: Shorter leukocyte telomere length is associated with cardiovascular risk and decreased nitric oxide bioavailability. Aforementioned are also linked with increased oxidative stress and inflammation. 1,2 Telomere length, NO metabolites (NOx), blood pressure, oxidative stress and inflammation...
Conference Abstract

162. P116 CARDIAC OUTPUT IS INCREASED IN YOUNG PEOPLE WITH ELEVATED BP

Chiara Nardin, Kaisa Maki-Petaja, Yasmin Yasmin, Barry McDonnell, John R. Cockcroft, Ian B. Wilkinson, Carmel M. McEniery
Pages: 113 - 113
Background: The relationship between Blood Pressure (BP) and cardiovascular risk is continuous. Here, we examined haemodynamic characteristics across a range of BP categories, to determine kihaemodynamic mechanisms associated with early elevations of BP and whether these differ by gender. Methods: 2618...
Conference Abstract

163. P117 ARTERIAL STIFFNESS, CAROTID REMODELING AND OTHER RISK FACTORS DETERMINING CORONARY ARTERY DISEASE IN HYPERTENSIVE PATIENTS

Luiz Bortolotto, Nadja Mendes, Valeria Costa-Hong, Luiz Cesar
Pages: 113 - 113
Increased arterial stiffness and carotid artery Intima-Media Thickness (IMT) are associated with atherosclerosis and Coronary Artery Disease (CAD), but their correlation with the anatomic extent of atherosclerosis in hypertensive patients is not completely known. We aim to evaluate whether Pulse Wave...
Conference Abstract

164. P118 CXCL13 AS A NOVEL POTENTIAL BIOMARKER OF ESSENTIAL HYPERTENSION

Yanina Timasheva, Vera Erdman, Timur Nasibullin, Ilsiyar Tuktarova, Olga Mustafina
Pages: 113 - 113
Background: Arterial hypertension is the main modifiable risk factor of cardiovascular disease. Inflammation and endothelial dysfunction contribute to arterial wall remodeling and blood pressure elevation, leading to the development of age-associated changes of cardiovascular system that limit the lifespan. Objectives:...
Conference Abstract

165. P119 LDL CHOLESTEROL IS ASSOCIATED WITH SYSTEMIC VASCULAR RESISTANCE AND WAVE REFLECTION IN SUBJECTS NOT USING MEDICATIONS WITH HAEMODYNAMIC INFLUENCES

Manoj kumar Choudhary, Arttu Eräranta, Antti J. Tikkakoski, Jenni Koskela, Elina Hautaniemi, Mika Kähönen, Jukka Mustonen, Ilkka Pörsti
Pages: 113 - 114
Background and Aim: Low density lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerosis, but it is also associated with elevated blood pressure (BP) and future development of hypertension. We examined the relationship between LDL-C and haemodynamic variables in normotensive and never-treated...
Conference Abstract

166. P120 DETERMINANTS OF BRACHIAL-ANKLE PULSE WAVE VELOCITY

Renata Bocskei, Bela Benczur, Attila Cziraki
Pages: 114 - 114
It has been proven that aortic pulse wave velocity (aoPWV) the measure of arterial stiffness is a strong and independent predictor of both cardiovascular events and all-cause mortality. Beyond the “gold standard” cfPWV brachial-ankle PWV (baPVW) measurement has been accepted for assessing arterial stiffness...
Conference Abstract

167. P121 ASSOCIATION OF CARDIORESPIRATORY FITNESS WITH ARTERIAL STIFFNESS AND PERIPHERAL AND CENTRAL BLOOD PRESSURE IN RESISTANT HYPERTENSION PATIENTS

Catarina Garcia, Susana Lopes, Susana Bertoquini, Verónica Ribau, Cátia Leitão, Daniela Figueiredo, Ilda P Ribeiro, Joana Barbosa de Melo, João L Viana, José Mesquita-Bastos, Jorge Polónia, Fernando Ribeiro, Alberto J Alves
Pages: 114 - 114
Background: The relationship between arterial stiffness, blood pressure (BP) and cardiorespiratory fitness (CRF) has been studied in healthy populations and cardiovascular patients, since all of which proved to be independent predictors of all-cause mortality. We aimed to investigate the association...
Conference Abstract

168. P122 THE ARTERIAL STIFFNESS DYNAMICS UNDER THE EFFECT OF ROSUVASTATIN ADDED TO DIFFERENT COMBINATIONS OF ANTIHYPERTENSIVE DRUGS

Olga Fedorishina, Konstantin Protasov, Anna Torunova, Nina Scherbakova, Natalia Petronchak
Pages: 114 - 115
We studied the influence of rosuvastatin adding to lisinopril/amlodipine or lisinopril/ hydrochlorothiazide fixed combinations on blood pressure (BP) and arterial stiffness dynamics in hypertensive patients of high or very high cardiovascular risk. Methods: 60 patients (36 men and 24 women aged 52.1...
Conference Abstract

169. P123 UNATTENDED AND ATTENDED BP VALUES AND VASCULARE AND CARDIAC ORGAN DAMAGE

Anna Paini, Massimo Salvetti, Fabio Bertacchini, Carlo Aggiusti, Sara Cappellini, Enrico Agabiti Rosei, Maria Lorenza Muiesan
Pages: 115 - 115
It has been suggested that measurement of “unattended” blood pressure values may provide advantages over conventional BP measurement; some hypertension guidelines now suggest this approach as the preferred one for measuring office BP. Data on the relationship between unattended BP and cardiovascular...
Conference Abstract

170. P124 CENTRAL BLOOD PRESSURE MEASUREMENT: PARADIGM SHIFT

Gilberto Campos Guimarães Filho, Weimar Kunz Sebba Barroso Sousa
Pages: 115 - 115
Introduction: It is estimated that currently 17 million deaths annually in the world occur due to cardiovascular disease (CV), about one third of all deaths. 9.4 million are related to arterial hypertension (HA). The use of methods that allow the early identification of structural and functional cardiovascular...
Conference Abstract

171. P125 ESTIMATION OF MEAN ARTERIAL PRESSURE IN NON-INVASIVE STUDIES

Chloe Park, Therese Tillin, Nish Chaturvedi, Alun Hughes
Pages: 115 - 116
Background: Mean arterial pressure (MAP) is required for many hemodynamic calculations. Most automated devices do not report MAP and a form factor (FF) is used to estimate it from systolic and diastolic blood pressure (BP). The appropriate choice of FF in the brachial artery is controversial: 0.33 is...
Conference Abstract

172. P126 THE ASSOCIATION OF THE INTEGRATED CENTRAL PRESSURE-STIFFNESS RISK SCORE WITH CARDIOVASCULAR MORTALITY IN HEMODIALYSIS PATIENTS

János Nemcsik, Dóra Batta, Ádám Tabák, Beáta Kőrösi, Orsolya Cseprekál, András Tislér
Pages: 116 - 116
Background: Our aim was to study the predictive power of ICPS risk categories on CV mortality in hemodialysis patients. Methods: In our retrospective cohort study 91 patients were involved from two dialysis centers. Pulse Wave Velocity (PWV), central systolic blood pressure (cSBP) and and central pulse...
Conference Abstract

173. P127 SPATIAL VARIATION OF RESERVOIR PRESSURE IN CHILDREN ASSESSED WITH HIGH FIDELITY PRESSURE MEASUREMENT IN FIVE AORTIC LOCATIONS

Jonathan Mynard, Lucas Eastaugh, Geoff Lane, Greta Goldsmith, Gabriella Springall, Alberto Avolio, Joe Smolich, Michael Cheung
Pages: 116 - 116
Objective: To assess whether reservoir pressure (Pres) in young individuals with a compliant aorta is uniform throughout the aorta, as has recently been reported in older adults with cardiovascular disease (1). Methods: High fidelity pressure was measured with a Verrata wire (Philips Volcano) in 5 aortic...
Conference Abstract

174. P128 RADIAL INTIMA-MEDIA THICKNESS ASSESSMENT BY ULTRA-HIGH FREQUENCY ULTRASOUND AND AUTOMATED IMAGE-ANALYSIS IN HEALTHY VOLUNTEERS

Nicole Di Lascio, Rosa Maria Bruno, Saverio Vitali, Davide Caramella
Pages: 116 - 117
Background: Ultrahigh-frequency ultrasound may represent a powerful tool for investigating the arterial properties of medium and small-size arteries. Aim of this study was: 1) to evaluate intra- and inter-operator reproducibility of radial artery vascular parameters (intima-media thickness –IMT- and...
Conference Abstract

175. P129 DETERMINATION OF THE DIASTOLIC PRESSURE DECAY CONSTANT (TAU) FROM RADIAL TONOMETRY: DEMOGRAPHIC AND HEMODYNAMIC ASSOCIATIONS IN NORMAL AND HYPERTENSIVE INDIVIDUALS

Joseph Izzo, Sherif El-sayed, Rahil Ahmed, Peter Osmond, Benjamin Gavish
Pages: 117 - 117
Introduction: The feasibility of measuring the diastolic pressure-decay constant (tau) in normal and hypertensive humans is not established and the clinical and physiological relevance of tau is not known. Methods: Studies were performed in the non-invasive cardiac laboratory in subjects who had been...
Conference Abstract

176. P130 COMPARISON BETWEEN PWV MEASURED FROM CUTANEOUS LENGTH BY SPHYGMOCOR AND BY MRI LENGTH TRACED ALONG THE WHOLE AORTA

Marina Cecelja
Pages: 117 - 117
Background: Accuracy of non-invasive PWV as m/sec is impeded by crude surface estimates of aortic length. We compared PWV measured using the Sphygmocor via surface length measurements with PWV measured using MRI with distance traced more precisely along the whole imaged aortic length. Methods: Magnetic...
Conference Abstract

177. P131 UTERINE ARTERIES EVALUATION DURING PREGNANCY: MODELING AND COMPUTATIONAL FLUID DYNAMICS CALCULATIONS

Andreia Serrano, Vanessa Cunha, Jorge Teixeira, Maria Pires, João O’Neill, Valentina Vassilenko
Pages: 117 - 117
Preeclampsia (PE) affects pregnancy, being one of the main causes of prenatal maternal mortality and morbidity (1). Recent studies show that PE is characterized by a significant reduction on maternal cardiac output and increased peripheral resistance. However, studies on the maternal hemodynamic adaptation...
Conference Abstract

178. P132 CONTINUOUS MEASUREMENTS OF CENTRAL BLOOD PRESSURE DURING MENTAL STRESS MONITORING

Valentina Vassilenko, Andreia Serrano, Paulo Bonifacio, Peter Roth, Viktor Fetter
Pages: 117 - 118
Nowadays employment world is increasingly shifting towards service-related labour, changing focus from physiological to psychological loads for workers. Thus, a deeper psychological stress understanding arises, not only for jobs within extreme conditions (as astronauts or pilots) but also for regular...
Conference Abstract

179. P134 A COMPUTATIONAL INVESTIGATION OF CONFOUNDING FACTORS AFFECTING FLOW MEDIATED DILATION: TOWARDS IMPROVED ENDOTHELIAL FUNCTION ASSESSMENT

Weiwei Jin, Phil Chowienczyk, Jordi Alastruey
Pages: 118 - 118
Objective and motivation: Endothelial dysfunction is associated with cardiovascular diseases. Flow mediated dilation (FMD), assesses the endothelial function by measuring the brachial artery vasodilation following deflation of a sphygmomanometer cuff around the forearm. Vasodilation is assumed to be...
Conference Abstract

180. P135 SYSTEMIC CARDIOVASCULAR INPUTS IN MODELS ESTIMATING INTRACRANIAL PRESSURE MAGNITUDE AND WAVEFORM

Julio A. Lara-Hernández, Isabella Tan, Mark Butlin, Alberto P. Avolio
Pages: 118 - 118
Background: Monitoring Intracranial Pressure (ICP) is key for appropriate clinical treatment of patients with conditions potentially causing raised ICP. The adequacy of using Heart Rate (HR), aortic Blood Pressure (aBP) and carotid Blood Flow (cBF) to estimate ICP magnitude (pulse and mean) and waveform...
Conference Abstract

181. P136 SIMULATING MYOCARDIAL OXYGEN BALANCE CHANGES DUE TO ANTI-HYPERTENSIVE DRUGS

Andrea Guala, Dario Leone, Francesco Tosello, Alberto Milan, Luca Ridolfi
Pages: 118 - 118
Background: Hypertension clinical treatment largely relies on different drugs. Some of these drugs are thought to exhibit specific protective functions in addition to those resulting from blood pressure reduction per se. Through a validated multiscale mathematical model of the cardiovascular system,...
Conference Abstract

182. P137 ESTIMATING LEFT VENTRICULAR ELASTANCE FROM NONINVASIVE AORTIC FLOW AND BRACHIAL PRESSURE MEASUREMENTS

Stamatia Pagoulatou, Nikolaos Stergiopulos
Pages: 118 - 119
Background and Aim: Left Ventricular (LV) End-systolic elastance (Ees) serves as a major determinant of cardiac systolic contractility. Traditional Methods: to evaluate the ventricular mechanics directly from measurements require intraventricular pressure and volume recordings during an acute preload...
Conference Abstract

183. P138 INFLUENCE OF ULTRASOUND SETTINGS ON CAROTID BIOMARKER ASSESSMENT BY B-MODE IMAGE PROCESSING

Martina Francesconi, Vincenzo Gemignani, Rachele Gherardini, Nicole Di Lascio, Francesco Faita, Lorenzo Ghiadoni, Rosa Maria Bruno, Elisabetta Bianchini
Pages: 119 - 119
Purpose/Background/Objectives: This study aims to investigate how image settings affect carotid Intima-Media-Thickness (IMT) and diameter estimation performed with CarotidStudio (Quipu Srl). Methods: 14 healthy volunteers (24.4 ± 4.4 years; 8 men) were recruited. Longitudinal scans 3cm deep of common-carotid-arteries...
Conference Abstract

184. P139 AUTOMATIC CLASSIFICATION OF ARTERIAL AND VENULAR TREES IN COLOUR FUNDUS IMAGES

M Elena Martinez-Perez, Kim Parker, Nick Witt, S.A.McG. Thom, Alun Hughes
Pages: 119 - 119
Background: Quantitative imaging of retinal arterioles and venules offers unique insights into cardiovascular and microvascular diseases but is laborious. We developed and tested a method to automatically identify Arterial/Venular (A/V) vessels in digital retinal images in conjunction with a semi-automatic...
Conference Abstract

185. P140 ARTERIAL WAVE DYNAMICS IN THE HORSE: INSIGHTS OBTAINED FROM A 1D ARTERIAL NETWORK MODEL SIMULATION

Daimé Campos Arias, Lisse Vera, Sofie Muylle, Nikos Stergiopulos, Gunther van Loon, Patrick Segers
Pages: 120 - 120
Background: Relatively little is known about equine arterial hemodynamics because it is technically and ethically challenging to investigate a large number of arteries. Pulsed-wave Doppler images of arterial flow velocities typically display patterns of a higher oscillatory nature than in humans, but...
Conference Abstract

186. P141 TELOMERE DYNAMICS RELATION WITH OBESITY

Simon Toupance, Mirna Chahine, Irini Tzanetakou, Carlos Labat, Sylvie Gautier, Cécilé Lakomy, Pascal Rossi, Toufic Moussallem, Pierre Yared, Didier Quilliot, Evangelos Menenakos, Roland Asmar, Athanase Benetos
Pages: 120 - 120
Background: The relation between telomere dynamics and obesity remains unclear. Cross-sectional studies found associations between short leukocyte telomere length (LTL) and high body mass index (BMI) but longitudinal studies did not find any association between LTL attrition and BMI. In two parallel...
Conference Abstract

187. P142 EARLY VASCULAR PARAMETERS IN THE MICRO- AND MACROCIRCULATION IN TYPE 2 DIABETES

Christian Ott, Dennis Kannenkeril, Marina Karg, Agnes Bosch, Joanna Harazny, Roland Schmieder
Pages: 120 - 120
Background: Diabetes converts from a metabolic disorder into a predominantly vascular disease, once its duration extends over several years or/and when additional cardiovascular risk factors such as hypertension coexist. We analyzed various vascular parameters in the renal, retinal and systemic circulation,...
Conference Abstract

188. P143 REDUCED LEVELS OF ANTI-AGEING HORMONE KLOTHO ARE ASSOCIATED WITH INCREASED AORTIC STIFFNESS IN PATIENTS WITH TYPE 2 DIABETES

Nikolaos Fountoulakis, Giuseppe Maltese, Luigi Gnudi, Janaka Karalliedde
Pages: 121 - 121
Background: Aortic Pulse Wave Velocity (Ao-PWV) predicts cardiovascular disease and renal dysfunction in Type 2 Diabetes (T2DM). Klotho is a circulating anti-ageing hormone that has direct cardio-renal protective effects in animal studies. We have previously demonstrated that circulating levels of Klotho...
Conference Abstract

189. P144 IMPACT OF ANTI-HYPERTENSIVE DRUGS ON AORTIC STIFFNESS INDUCED BY CHRONIC KIDNEY DISEASE AND MINERAL BONE DISORDER IN RATS

Mohsen Agharazii, Roth-Visal Ung, Sarah-Kim Bisson, Fabrice Mac-Way, Darren E. Richard, Richard Larivière
Pages: 121 - 121
Background: In chronic kidney disease (CKD), anomalies of mineral bone disorder (MBD) play a central role in vascular calcification and increased aortic stiffness. The impact of antihypertensive drugs on MBD-induced vascular calcification remains uncertain. The aim of this study was to examine whether...
Conference Abstract

190. P145 ARTERIAL STIFFNESS AND LEFT VENTRICULAR DIASTOLIC FUNCTION IN PATIENTS WITH METABOLIC SYNDROME: LONGITUDINAL STUDY

Svetlana Solovjova, Ligita Ryliskyte, Roma Puronaite, Jelena Celutkiene, Aleksandras Laucevicius, Jolita Badariene, Ieva Slivovskaja, Egidija Rinkuniene
Pages: 121 - 122
Aim: To evaluate the relation between arterial stiffness and left ventricular diastolic dysfunction (LVDD) in metabolic syndrome (MetS) patients during more than 3 years observation period (average was 3,8 years). Methods: This longitudinal study enrolled 573 subjects (aged 53,4 ± 6 years, 63% female,...
Conference Abstract

191. P146 ANALYSIS OF RENAL ARTERY REVASCULARIZATION IN A TERTIARY CARE CENTRE

Pedro Marques, Luís Flores, André Carvalho, Joel Sousa, Patrícia Lourenço, Jorge Almeida
Pages: 122 - 122
Renovascular hypertension is an uncommon cause of secondary hypertension. Percutaneous angioplasty is considered in selected patients. Retrospective study of patients undergoing renal artery revascularization, in a tertiary centre, in 2004–2017. Demographic, biometrical, radiological and clinical data...
Conference Abstract

192. P147 ASSOCIATIONS BETWEEN RESERVOIR PRESSURE PARAMETERS AND KIDNEY FUNCTION ARE DEPENDENT ON THE ARTERIAL MEASUREMENT SITE

Matthew Armstrong, Dean Picone, Martin Schultz, James Sharman, Nathan Dwyer, Philip Roberts-Thomson, Andrew Black
Pages: 122 - 122
Introduction: Reservoir pressure parameters derived from pressure waveforms captured at various arterial sites predict adverse kidney function independently of conventional cuff blood pressure (BP). However, there has never been an analysis directly comparing if associations with kidney function may...
Conference Abstract

193. P148 ANTHROPOMETRIC MEASURES IN INTERMITTENT CLAUDICATION AND CRITICAL LIMB ISCHEMIA

Joana Ferreira, Jacinta Campos
Pages: 122 - 122
Purpose/Background/Objective: Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis and obesity is one of its well-established risk factors 1–5. PAD is classified in intermittent claudication (IC) and critical limb ischemia (CLI), according to the its severity6. Therefore, we...
Conference Abstract

194. P149 LOW CAROTID ARTERIAL STIFFNESS IN YOUNG TYPE1 DIABETIC PATIENTS COMPARED WITH AGE-MATCHED CONTROLS

Alessandro Giudici, Carlo Palombo, Carmela Morizzo, Michaela Kozakova, Lorenzo Losso, Kennedy J. Cruickshank, Ashraf W. Khir
Pages: 123 - 123
Background: Local pulse wave velocity (c) is widely used as an index of local carotid arterial stiffness. In middle-aged type1 and type2 diabetic patients, arterial stiffness is higher than in healthy people, but much less data are available for young subjects. Our aim was to quantify the changes in...
Conference Abstract

195. P150 THE IMPACT OF ARTERIAL STIFFNESS ON TROPONIN T LEVELS IN CHRONIC HAEMODIALYSIS PATIENTS

Christian Daugaard Peters, Krista Dybtved Kjærgaard, Bente Jespersen, Kent Lodberg Christensen, Jens Dam Jensen
Pages: 123 - 123
Background: Troponin T (TnT) is a highly specific biomarker for myocardial infarction (MI). Haemodialysis (HD) patients often have increased arterial stiffness and elevated TnT. Previous studies have linked elevated TnT with worse outcome, even in the absence of MI. The aim of this study was to evaluate...
Conference Abstract

196. P151 ARTERIAL STIFFNESS RESPONSE TO ACUTE AEROBIC AND RESISTANCE EXERCISE IN OLDER PATIENTS WITH CORONARY ARTERY DISEASE

Vanessa Santos, Rafaela Netas, Mariana Borges, Xavier Melo, Rita Pinto, Vitor Angarten, Fernhall, Helena Santa-Clara
Pages: 123 - 123
Introduction: Arterial stiffness is associated with coronary artery disease (CAD). Acute aerobic exercise decreases arterial stiffness, while acute resistance exercise increases arterial stiffness. There is little information on the effect of such exercise on arterial stiffness in older patients with...
Conference Abstract

197. P152 THE EFFECT OF SURGICAL AORTIC VALVE REPLACEMENT ON AORTIC STIFFNESS AND THE PROGNOSTIC ROLE OF AORTIC STIFFNESS ON SURGICAL SUCCESS

Evangelia Sigala, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Konstantinos Triantafillou, Nikolaos Koumallos, Andreas Katsaros, Vasilios Lozos, Ilias Kouerinis, Nikolaos Giakis, Michael Demosthenous, Konstantinos Filis, Dimitrios Tousoulis
Pages: 124 - 124
Purpose/Background/Objectives: Aortic stiffness and hemodynamics are established biomarkers for cardiovascular events. Surgical aortic valve replacement (SAVR) remains the first choice of treatment in most patients with aortic stenosis. We investigated the effect of SAVR on aortic stiffness and the role...
Conference Abstract

198. P153 PULSE WAVE VELOCITY DISTRIBUTION IN CHILDREN AT A SCHOOL IN THE NORTH OF PORTUGAL

Mariana Formigo, Cristina Silva, Nuno Formigo, Sara Freitas, Cristina Cunha, Margarida Rocha, Clarisse Neves, Laura Castro, Filipe Gonçalves, Maria J. Cotter, Pedro G. Cunha, Jorge Cotter
Pages: 124 - 124
Background: Pulse Wave Velocity (PWV) is a measure of arterial stiffness and vascular aging and an important parameter for cardiovascular risk stratification. A previous study showed high prevalence rates of early vascular aging in an adult population from the North of Portugal. The aim of this study...
Conference Abstract

199. P154 DOES THE METHOD OF THE MEASUREMENT OF BLOOD PRESSURE CORRELATES DIFFERENTLY WITH PULSE WAVE VELOCITY IN RESISTANT HYPERTENSION?

Jose Mesquita Bastos, Susana Lopes, Catarina Garcia, Verónica Ribau, Susana Bertoquini, Cátia Leitão, P. Ribeiro Ilda, Daniela Figueiredo, L. Viana João, Fernando Ribeiro, Jorge Polónia
Pages: 124 - 125
Objective: Carotid-femoral Pulse Wave velocity (cfPWV), the gold standard for measuring stiffness, is a marker of organ damage (OLD). Even though cfPWV correlates with casual (BPc), central (CBP) and ambulatory (ABPM) blood pressure (BP), evidence is limited for resistant hypertension (RH). Method:...
Conference Abstract

200. P155 DETERMINANTS OF PULSE WAVE VELOCITY IN CHILDREN

Cristina Silva, Mariana Formigo, Nuno Formigo, Sara Freitas, Cristina Cunha, Margarida Rocha, Clarisse Neves, Laura Castro, Filipe Gonçalves, Maria J. Cotter, Pedro G. Cunha, Jorge Cotter
Pages: 125 - 125
Background: Arterial stiffening measured by Pulse Wave Velocity (PWV) predicts cardiovascular events and mortality in adults. It advances with age and seems accelerated in children with certain disease conditions such as chronic kidney disease or diabetes. The aim of this study was to determine factors...
Conference Abstract

201. P156 CARDIO ANKLE VASCULAR INDEX (CAVI) AS ARTERIAL STIFFNESS MARKER IN SUBJECTS WITH ANKYLOSING SPONDYLITIS

Guillermo Alanis-Sánchez, Ernesto Cardona-Muñoz, David Cardona-Müller, Sylvia Totsuka-Sutto, Oscar Mares-Flores, César Murguia-Soto, Diego Castañeda-Zaragoza, David Montes-Martínez, Carlos Ramos-Becerra
Pages: 125 - 125
Background: Ankylosing spondylitis (AS) is a chronic, inflammatory disease of the axial spine that can manifest with various clinical signs and symptoms1.Cardio-ankle vascular index (CAVI), which is calculated based on the stiffness parameter thus obtained, is theoretically independent of changes in...
Conference Abstract

202. P157 AORTIC CALCIFICATIONS AND INFLAMMATION ARE ASSOCIATED WITH IN-HOSPITAL COMPLICATIONS IN ACUTE CORONARY SYNDROME

Konstantia-Paraskevi Gkini, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Iosif Koutagiar, Angeliki Rigatou, Stavroula Pantou, Christos Georgakopoulos, Dimitrios Tousoulis
Pages: 125 - 126
Purpose/Background/Objectives: Aortic calcifications and inflammation are independent predictors of adverse cardiovascular events. We sought to investigate the association of aortic calcifications and inflammation with in-hospital morbidity and mortality of patients with acute coronary syndrome (ACS). Methods:...
Conference Abstract

203. P158 ARTERIAL STIFFNESS IN THE VERY OLD: THE AGA@4LIFE RESEARCH PROJECT

Telmo Pereira
Pages: 126 - 126
Objective: To study the determinants of Arterial Stiffness (AS) in the elderly. Design and method: Cross-sectional, observational study of elderly participants. Blood Pressure (BP) and arterial function parameters were measured with a validated device. Clinical and demographic information was gathered,...
Conference Abstract

204. P159 CORRELATION BETWEEN INFLAMMATORY STATE AND ARTERIAL STIFFNESS

Daniele Brustolim, Lucelia Magalhaes, Diorlene Silva, Rodrigo Sant’Ana de Lima, Vinicius Louzada Castro, Daniel Malta Ribeiro, Caroline Rodrigues Fidelman, Natalia Damasceno, Larissa Vasconcelos, Caroline Ventura, Vascor Group
Pages: 126 - 126
Pulse wave velocity (PWV) is gold standard for assessing arterial stiffness. Studies have shown that people with metabolic syndrome have insulin resistance and that after the onset of diabetes, cardiovascular risk is intensely increased, high-sensitive C-reactive protein (hsCRP) (1). Relate influence...
Conference Abstract

205. P160 ASSESSMENT OF CAROTID PULSE WAVE VELOCITY (CARPWV) IN PATIENTS WITH ANKYLOSING SPONDYLITIS

Guillermo Alanis-Sánchez, Carlos Ramos-Becerra, David Cardona-Müller, Patricia Quezada-Fernández, Sara Pascoe-González, César Murguia-Soto, Ernesto Cardona-Muñoz
Pages: 126 - 127
Introduction: Ankylosing spondylitis (AS) is an inflammatory rheumatic disease associated with accelerated atherosclerosis and increased cardiovascular morbidity and mortality. Objectives: To assess the local arterial stiffness in carotid artery in subjects with AS compared with controls evaluated by...
Conference Abstract

206. P161 RELATIONSHIP OF FIBRINOGEN WITH ARTERIAL STIFFNESS IS DIFFERENT ACCORDING TO GENDER. EVA STUDY

Leticia Gomez-Sanchez, Marta Gomez-Sanchez, Natalia Sanchez-Aguadero, Cristina Lugones-Sanchez, Maria C. Patino-Alonso, Sara Mora-Simon, Jose A. Maderuelo-Fernandez, Emiliano Rodriguez-Sanchez
Pages: 127 - 127
Objectives: To analyze the association of arterial stiffness with the fibrinogen in general population without previous cardiovascular diseases. Differences by gender. Methods: A cross-sectional study. Study population: From the population assigned to the participating healthcare centres, a cluster...
Conference Abstract

207. P162 ARTERIAL STIFFNESS AND BODY COMPOSITION IN CHILDREN AND ADOLESCENTS

Tommy Cai, Alice Meroni, Hasthi Dissanayake, Melinda Phang, Ahmad Qasem, Julian Ayer, Mark Butlin, Alberto Avolio, David Celermajer, Michael Skilton
Pages: 127 - 127
Objectives: Carotid-femoral pulse wave velocity (cfPWV) is a validated non-invasive measure of aortic stiffness. Risk factors for cfPWV are well described in adulthood, and furthermore cfPWV is associated with incident cardiovascular disease in adults (1). However, risk factors for arterial stiffness...
Conference Abstract

208. P163 REGIONAL DIFFERENCES IN GEOMETRICAL FEATURES AND LAYER-SPECIFIC RESIDUAL STRESSES IN THE BOVINE DESCENDING THORACIC AORTA

Alessandro Giudici, Ian B. Wilkinson, Ashraf W. Khir
Pages: 127 - 128
Background: The Opening Angle (OA) is widely used as an index of the residual stresses and strains present in the arterial wall not subjected to internal pressure. The aim of this work was to quantify regional variation of the layer-specific OA in the bovine descending thoracic aorta. Methods: Descending...
Conference Abstract

209. P164 INDICES TO ASSESS AORTIC STIFFNESS FROM THE FINGER PHOTOPLETHYSMOGRAM: IN SILICO AND IN VIVO TESTING

Peter Charlton, Maria Aresu, Jeanette Spear, Phil Chowienczyk, Jordi Alastruey
Pages: 128 - 128
Purpose: Aortic stiffness is predictive of cardiovascular morbidity and mortality. However, the gold standard method for assessing aortic stiffness, carotid-femoral pulse wave velocity, is time-consuming and requires a trained operator. An alternative approach could be to derive an arterial stiffness...
Conference Abstract

210. P165 EVALUATING CAROTID FEMORAL PULSE WAVE VELOCITY MEASURED BY CUFF-BASED APPROACH AGAINST THE TONOMETRY-BASED REFERENCE STANDARD IN A PAEDIATRIC POPULATION

Tommy Cai, Alice Meroni, Hasthi Dissanayake, Melinda Phang, Alberto Avolio, David Celermajer, Mark Butlin, Michael Skilton, Ahmad Qasem
Pages: 128 - 128
Background: Carotid femoral pulse wave velocity (cfPWV) is directly associated with arterial stiffness in major elastic arteries and predicts future cardiovascular events (1). Little is known of cfPWV as a marker of vascular health in children. Semi-automated cuff-based devices for assessing cfPWV are...
Conference Abstract

211. P166 AORTIC PULSATILITY, AND NOT MEAN ARTERIAL PRESSURE, IS AN INDEPENDENT DETERMINANT OF LEFT MAIN CORONARY ARTERY DISEASE

Azra Mahmud, Ali AlGhamdi, Mohamamd Balghith, Kamal Ayoub, Mohammad Fayaz Khan, Samir Al-Chighouri, Fawaz AlMutairi, Muayed AlZaibag
Pages: 129 - 129
Introduction: Left Main Coronary Artery (LMCA) disease is prognostically the most important coronary lesion. LMCA differs from the other coronaries in having high elastin content. Aortic Pulsatility (AP) is an independent predictor of cardiovascular events in CAD. We hypothesized that pulsatile stress...
Conference Abstract

212. P167 ACUTE EXERCISE EFFECTS ON VASCULAR AND AUTONOMIC FUNCTION IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE

Vitor Angarten, Rita Pinto, Vanessa Santos, Xavier Melo, Paula Sousa, Jose Carlos Machado, Helena Santa Clara
Pages: 129 - 129
Purpose: To examine the acute effect of maximal exercise effort on pulse wave velocity (PWV) and heart rate variability (HRV) in patients with CAD with a range of functional capacity levels, and the association between these parameters 1,2,3. Methods: Thirty-six patients with CAD (62 ± 10 y) ranging...
Conference Abstract

213. P168 FEASIBILITY STUDY OF LOCAL PULSE WAVE VELOCITY ESTIMATION IN THE CAROTID ARTERY WITH MULTI-BEAM LASER DOPPLER VIBROMETER

Daniela Tommasin, Yanlu Li, Jonathan Reeves, Roel Baets, Steve Greenwald, Patrick Segers
Pages: 129 - 130
Background: An innovative device using Laser Doppler Vibrometry (LDV) has been designed [1] to measure the transit time of the pulse wave between two locations along the course of the carotid artery (CA) from skin surface vibrations for assessment of local pulse wave velocity (PWV) [2]. Aim: Tests were...
Conference Abstract

214. P169 RELATIONSHIP BETWEEN COMMON CAROTID DISTENSIBILITY/AORTIC STIFFNESS AND LEFT VENTRICULAR MORPHOLOGY AND FUNCTION IN RHEUMATOLOGIC PATIENTS

Michele Bevilacqua, Andrea Dalbeni, Angela Tagetti, Luca Gomarasca, Giovanni Orsolini, Andrea Giollo, Maurizio Rossini, Ombretta Viapiana, Giovanni Cioffi, Pietro Minuz, Cristiano Fava
Pages: 130 - 130
Introduction: Arterial stiffness is known to be associated with atherosclerosis, cardiac remodelling and cardiovascular diseases. In recent studies, common carotid artery rigidity was seen to better predict cardiac morphology and function if compared to aortic parameters. The aim of the study was to...
Conference Abstract

215. P170 A FOREHEAD AND NASAL BRIDGE PULSE OXIMETER COMPARISON MEASUREMENTS ON HEALTHY SUBJECTS

Matti Huotari, Juha Röning, Kari Määttä
Pages: 130 - 130
Photoplethysmography (PPG) is a biophotonic technique which measures blood volume variations in vascular bed and it is well known for its utilization in pulse oximetry for the estimation of arterial blood oxygen saturation. Moving particles within the tissue bed generate rapidly changing absorption caused...
Conference Abstract

216. P171 CARDIOVASCULAR RISK EVALUATION IN BEHCET’S PATIENTS – THE ROLE OF CHRONIC INFLAMMATION IN ARTERIAL STIFFNESS

Maria Guimarães, Glória Alves, Cristina Cunha, Marta Cunha
Pages: 130 - 132
Introduction: Behcet’s disease (BD) is a chronic inflammatory syndrome with systemic manifestations. Systemic vasculitis contribute to vascular aging, increasing the arterial stiffness that can be inferred from the Pulse Wave Velocity (PWV) measurement. Carotid ultrasound evaluation allows vascular wall...
Conference Abstract

217. P172 ROLE OF ADIPOSE TISSUE AND SKELETAL MUSCLE IN MACROVASCULAR ATHEROSCLEROTIC OCCLUSIVE DISEASE-PERIPHERAL ARTERIAL DISEASE AND CAROTID ARTERY DISEASE

Joana Ferreira
Pages: 132 - 132
Purpose/Background/Objective: Carotid artery disease (CAD) and peripheral arterial disease (PAD) are non-cardiac manifestations of atherosclerotic disease, which are less extensively studied. Presently, adipose tissue (AT) and skeletal muscle (SM) are considered endocrine organs, producing cytokines...