Artery Research

Volume 24, Issue C, December 2018, Pages 68 - 68

1.5 DEEP VASCULAR PHENOTYPING IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA

Authors
Rosa Maria Bruno1, 2, Louise Marais2, Hakim Khettab3, Aurélien Lorthioir3, Xavier Jeunemaitre4, 2, Stèphane Laurent3, 2, Pierre Boutouyrie3, 2, Michel Azizi3
1University of Pisa, Italy
2INSERM U970, Paris, France
3APHP, Hôpital Européen Georges Pompidou, Paris, France
4APHP, Hôpital Européen Georges Pompidou, France
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.022How to use a DOI?
Abstract

Background: Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease involving medium-sized muscular arteries, whose pathophysiology is still unknown.

Objectives: We aimed at identifying systemic vascular alterations in usually non-affected arteries of patients with multifocal renal FMD by a deep imaging-based phenotyping.

Methods: This cross-sectional study included FMD patients (n = 50, 84% hypertensives), age-, sex and BP-matched patients with primary hypertension (PH, n = 50) and healthy normotensive subjects (HS, n = 50). Brachial artery (BA) endothelium-dependent flow-mediated dilation (EDD) and endothelium-independent vasodilation (EID) were studied. Aortic stiffness was assessed by carotid-to-femoral pulse wave velocity (PWV). We quantified abnormal echographic patterns in the common carotid wall by the triple signal score. Common carotid Young’s incremental elastic modulus (Einc)/stress curves were also plotted.

Results: FMD patients had impaired EID compared to PH and HS (p = 0.008, after adjustment for confounders p = 0.002), smaller BA diameter but comparable EDD and PWV. The prevalence of triple signal score >6 was 56%, 40%, 24% in FMD, PH and HS respectively (p = 0.005). FMD, but not PH, was significantly associated with triple signal (beta = 0.143, p = 0.022, r2 = 0.058). Impaired EDD was only present in FMD patients with triple signal score>6 (p for interaction=0.047). For a given stress value of 80 kPa, Einc was higher in the presence of a triple signal score >6, especially in FMD patients.

Conclusions: Non-affected musculo-elastic and muscular arteries in patients with multifocal renal FMD exhibit a cluster of functional and structural abnormalities, while elastic arteries are preserved. Triple signal in FMD may identify a distinct vascular phenotype.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
68 - 68
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.022How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Louise Marais
AU  - Hakim Khettab
AU  - Aurélien Lorthioir
AU  - Xavier Jeunemaitre
AU  - Stèphane Laurent
AU  - Pierre Boutouyrie
AU  - Michel Azizi
PY  - 2018
DA  - 2018/12/04
TI  - 1.5 DEEP VASCULAR PHENOTYPING IN PATIENTS WITH FIBROMUSCULAR DYSPLASIA
JO  - Artery Research
SP  - 68
EP  - 68
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.022
DO  - 10.1016/j.artres.2018.10.022
ID  - Bruno2018
ER  -