Artery Research

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Volume 24, Issue C, December 2018, Pages 94 - 94

P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS

Authors
Alun Hughes1, 2, Kim Parker3, Ashraf Khir4
1Department of Population Science & Experimental Medicine, Institute of Cardiovascular Science, University College London, UK
2MRC Unit for Lifelong Health and Ageing at UCL, University College London, UK
3Department of Bioengineering, Imperial College London, UK
4Brunel Institute for Bioengineering, Brunel University, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.106How to use a DOI?
Abstract

Background: Zero flow pressure (P∞), the steady-state pressure following cardiac arrest or cessation of flow is often assumed to equal mean circulatory filling pressure (MCFP). [1] However, this assumes complete equilibration of circulatory pressures, which may not occur if there is a ‘critical closing pressure’ or ‘Waterfall’ in the circulation. We undertook a systematic review and meta-analysis to obtain robust estimates of P∞ and compared this with MCFP measured in the same studies.

Methods: A literature search was performed using PubMed and was limited to full articles in English using the search terms "mean circulatory filling pressure” OR "critical closing” OR "zero-flow". Only data relating to measurements of pressure following cardiac arrest or cessation of blood flow were included. Other exclusions were: individual case-reports, pregnancy, non-adult animals, not mammalian, or any non-human models of disease. Meta-analysis was performed using a random effects model in Stata 15.1. Data are mean (95% confidence intervals).

Results: A total of 1082 unique publications were identified; 1062 were excluded during screening. The remaining 20 studies with P∞ data were used to perform a meta-analysis. These included data from dog, rat, pig and human; 8 of these articles also provided data on MCFP. From this analysis P∞ = 26.5(23.4, 29.5) mmHg (n = 20) and the difference between P∞ and MCFP was 15.1(12.0, 18.3) mmHg (n = 8).

Conclusions: P∞ and MCFP differ substantially, indicating non-equilibration of pressures in the circulation following cessation of flow at least in the short-term (seconds to minutes).

Open Access
This is an open access article distributed under the CC BY-NC license.

References

1.AC Guyton, D Polizo, and GG Armstrong, Mean circulatory filling pressure measured immediately after cessation of heart pumping, Am J Physiol, Vol. 179, 1954, pp. 261-7.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
94 - 94
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.106How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Alun Hughes
AU  - Kim Parker
AU  - Ashraf Khir
PY  - 2018
DA  - 2018/12/04
TI  - P53 ZERO FLOW PRESSURE (PINFINITY) IS LARGER THAN MEAN CIRCULATORY FILLING PRESSURE. A SYSTEMATIC REVIEW AND META-ANALYSIS
JO  - Artery Research
SP  - 94
EP  - 94
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.106
DO  - 10.1016/j.artres.2018.10.106
ID  - Hughes2018
ER  -